Sure, it's profit motivated, but the "do no harm" of the Hippocratic oath should be in effect, and by not looking at these upper ranges, collecting valid data for future research and themselves to base a diagnosis off of, is harmful. If it was all a money sink, then why did they ever stand up to cancer?
I saw the top rated ENT in my city and I live somewhere surrounded by research universities so you'd think 5 stars in a big city means a lot. My main complaints were hearing sensitivity, severe fullness and horrible tinnitus all of which that ENT attributed to some slight redness in my left nostril that he glanced at for a second. I was about a month out from a really bad cold.
I agree with what you say but I also think it's because ENTs and audiologists know they can't do anything beyond 8 kHz hearing damage. Surgery can't cure SNHL and the only treatment they have is hearing aids at and under 8 kHz. Hearing aids can't help people with hearing loss higher than 8 kHz and if the standard audiogram only shows hearing loss beyond 8 kHz, then they can't do anything at all, which makes them look incompetent and useless. I think it's this reason that many doctors are seemingly unsympathetic and do not take us seriously except to offer "habituation" because there is NOTHING they can do.
we're on the same team here and I agree with your statements
So, FX-322 is designed to regenerate hearing only on ranges you have support cells. If you are deaf on your tinnitus tone frequency, if it's in the upper ranges, then you have moved past it. I should have explained if your loss is around 90 dB we aren't certain it would fix it.
I agree. I'm sure the average ENT has thought about this stuff too. They probably suggest habituation because they don't want a patient who could benefit from it to never try it. I am cautiously optimistic that after FX-322, Otonomy, Hough, etc. ENTs will magically become more thoughtful about this stuff because they know they can think out loud a bit more.
Yeah, sorry if I seem argumentative, that's not my intent either. Yeah, I see what you mean about the do no harm bit. Hopefully FX-322 changes that.Well in their minds they're not doing any harm. And cancer isn't an invisible illness.
Join any support group or forum for neurological pain or invisible illnesses and all you'll get is stories of people being misdiagnosed, walking out without being helped, doctors throwing up their hands and saying they can't help or sending people off to psychiatrists. "Do no harm" doesn't seem to hold much value these days
I'm not sure if it's coming off that way but I'm not arguing with you btw
By me saying " I understand" why ENT's/audiologists do what they do I don't mean to say I'm siding with them or thinking that it's the right way of doing things. I think it's wrong. I guess I just meant to say with the information they have/or lack of, as well as treatment options I see why they operate the way they do but that doesn't mean it doesn't need to change
I see!
Then FX-322 could help with the other tones, or all the tones, depending on whether there's support cells in the area. Granted, I'm vainly hoping that getting a few of the support cells going sorta restarts the ear and has it fix upper levels too, but that's a long shot.
Some of them seem to have an inkling of awareness that there's more going on in the cochlea than their textbooks teach, and they'll lend credence to your symptoms. But they can't diagnose shit so their medical explanation is at best a nebulous guess going off of their simplistic understanding and diagnostics. The ENTs theory on my sound sensitivity, muffled hearing, ear crackling and tinnitus was all due to "oversensitized middle ear muscles."
I think you are wrong Will. something can still be damaged in the area to cause it. For instance what if there is enough hearing loss that you can still make out the sound but it's different than if you had all of the hair cells. And yes there could be several other contributing factors. Also I think most high frequency tinnitus is well within the hearing range. I'm not sure if it's your posts but I have seen it come up several times where I see the individual say something that I don't think is scientifically correct and unnecessarily pessimistic. I can go try to look it up again and make this more organized and speak directly to those posts, and make this more well written but I think my point is in here. Yes, you do still need some support cells.
It's a shame Carl LeBel didn't talk about patients with severe or profound hearing loss and possible effects the drug might have on them on the Tinnitus Talk Podcast interview. Right now they're only accepting patients up to 70 dB hearing loss, but in the press release with regards to the private placement, they said they would use the proceeds to gain better insight into the 'severity' of the hearing loss FX-322 might treat. That could either mean they are going beyond 70 dB or have indication it doesn't work that well for more severe hearing loss.
Well, then if you damaged something but it's not showing up on the audiogram, it could be hidden hearing loss, which OTO-413 is looking to treat. Which, there's some possibility of FX-322 treating a bit of that too if I recall correctly, though that wasn't the main intent. At least Carl LeBel made it sound like it might happen as well. It certainly happens for the hair cells that do regrow.
That's not a bad guess. I'm having them all cut surgically due to oversensitivity.
He did say in the interview, however, that he thought it might work on anyone without flat epithelial. That means they aren't excluding 70-90 dB losses in that statement at least (which is still pretty deaf) and it can even be interpreted that he implied it will help that subset too.
They are following/testing patients for months after dosing and are still recruiting. It's August.
Their Phase 1 study chose mild, moderate, and severe hearing loss patients. Phase 1 is primarily testing for adverse side effects but FX-322 was also doing an informal efficacy measurement along the way. They can't include people with profound hearing loss because those are not people that can be measured for adverse effects.
I hear ya. I'm a designer and I generally work on the computer all day and there are times when I have to work on something tedious that takes hours to complete. My mp3 library on my computer helped me so much in being productive. It could make any boring process fun. Not anymore though. Now it's just a depressing reminder of the state of my ears. On top of it sounding low quality, I don't have my loudness sensitivity anymore so I can't tell when it is too loud or not. So I figure it's best not to listen to it.
Tiny frequency range? It affects from 8 kHz and above right now, so long as there are support cells.
There was a post saying that they won't be delaying results as they would have to inform the stock market of this by now, noting that they should know whether they can release the trial results in time or not. Either they have not announced a delay yet or they are going to try and release some preliminary results after September and further results later on.
With regards to FX-322, don't forget that they have only used a small single safety dose thus far so it's far too early to make any conclusive statements about the frequency range it will affect.
I think we're getting too caught up in the measured range of the sound frequencies and not focusing enough on how meaningful they are from a biological standpoint. For some reason, treating that small range has resulted in significantly improved word scores in both quiet and noise. It's also resulted to anecdotal reports of tinnitus improvement. This is what we know from testing it on a small group of 15 people.
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