Member- Jan 5, 2020
- 90
- Tinnitus Since
- 2011, Spike 2019, Spike 2020
- Cause of Tinnitus
- 1e Loud Music, 2e earwax irrigation, 3e padel tennis
Frequency Therapeutics — Hearing Loss Regeneration
- Thread starter RB2014
- Start date
Potential IHC loss (without OHC) as occurs in some ototoxins would be an example. As would people who have more mild loss and notches between measured frequencies without enough widespread loss to show up on tested audiogram frequencies would be another example.
I think it will definitely be used off label in people with "normal" audiograms, even extended ones.
It is very hard to find an audiologist in Australia who will actually do speech in noise testing. Although it seems that there is more of this being done now.
Inevitably I think that we will have a treatment for damaged synapses, although the question is how far away are we from having one.
Otonomy, Hough and also Pipeline are working on synapse related treatments. Hough has predicted an availability of 2025 or before. And I am pretty certain Otonomy and Pipeline are commencing clinical trials either this year or early next year. I still believe we may have a synaptic treatment available prior to Hough's, especially if one of the others turns out to be successful.
- Sep 21, 2016
- 1,051
- Tinnitus Since
- 2011 - T, 2016- H, relapsed 2019
- Cause of Tinnitus
- noise-induced
- Apr 15, 2017
- 1,419
- Tinnitus Since
- 2008
- Cause of Tinnitus
- Noise
FREQ share price dropped up to 15% today. Any idea if there was a catalyst for it or just good ole nature of biotechs? Can't find anything.
From what I can observe, it is highly probable that this had a lot to do with the sector more than anything. There doesn't seem to be any specific news relating to Frequency Therapeutics or any of the other biotech firms that had price declines.
Just seen reports informing us that Trump has talked about what he is going to do to restrict prescription medicine price increases. It is likely that this would explain why there has been a fall in the sector overall.
Thuan
Member
- Jul 5, 2020
- 221
- Tinnitus Since
- 05/2018
- Cause of Tinnitus
- Ear infection right ear 2018. Sound trauma left ear 2020.
- Feb 14, 2020
- 1,630
- Tinnitus Since
- 1-2019
- Cause of Tinnitus
- 20+ Years of Live Music, Motorcycles, and Power Tools
A lot of biotechs are way down (Arcturus is also down 13% for literally no reason). The IBB is down too.
Per Stat News there was a deadline today for an agreement with pharma companies and that deadline passed. It's the only thing I could find.
https://www.statnews.com/2020/08/21/phrma-scrambles-drug-pricing-ultimatum/
According to this paper:
https://web.archive.org/web/2019120...ic-files/6d161090-16f5-49f4-9606-8caceb5a88a1
They use Sodium Valproate and GSK-3β inhibitor.
Do you guys think you could get similar results if you orally took Sodium Valproate combined with GSK-3β inhibitor such as lithium salts which are GSK-3β inhibitors?
https://web.archive.org/web/2019120...ic-files/6d161090-16f5-49f4-9606-8caceb5a88a1
They use Sodium Valproate and GSK-3β inhibitor.
Do you guys think you could get similar results if you orally took Sodium Valproate combined with GSK-3β inhibitor such as lithium salts which are GSK-3β inhibitors?
I have read with interest some references in the forum about Frequency Therapeutics potentially planning research into male baldness in the hopes of producing game-changing treatment.
I have failed to find any news articles of this company addressing this issue.
Anyone else?
I have failed to find any news articles of this company addressing this issue.
Anyone else?
- Apr 15, 2017
- 1,419
- Tinnitus Since
- 2008
- Cause of Tinnitus
- Noise
- Feb 6, 2018
- 1,169
- Tinnitus Since
- 11/2002; spike 2009; worse 2017-18
- Cause of Tinnitus
- Loud music - noise damage
Frequency Therapeutics have mentioned before at a conference about treating baldness and cartilage disorders (@FGG said this).
Frequency Therapeutics have also filed patents for hair follicle proliferation to treat baldness:
http://appft.uspto.gov/netacgi/nph-...peutics&FIELD1=&co1=AND&TERM2=&FIELD2=&d=PG01
No. Nothing seems to have been released regarding a proposed baldness treatment.
I think that it will be highly likely that Frequency Therapeutics will work on a baldness treatment. However I also believe that this will not be a priority, especially when compared to other treatments that Frequency Therapeutics are considering. Currently there are numerous treatment options that are available to treat baldness such as hair regrowth treatments and hair transplants.
Therefore I think that Frequency Therapeutics will focus on novel areas of treatment like they are currently doing with Multiple Sclerosis and hearing. These are far more lucrative from a financial perspective from the simple fact that at least for now they will be a monopolised treatment. This will mean that Frequency Therapeutics can charge a higher price for the medicine and also won't need to compete with other entities for market share either.
@Billy_Shears, they had a graphic up at one of the earlier conferences where they described both baldness and joint disease as future applications of their PCA platform. They aren't going to have press releases on this because they are still very pre-clinical for these applications at this point. For now, the company is focused on two applications: hearing loss and MS.
- Sep 21, 2016
- 1,051
- Tinnitus Since
- 2011 - T, 2016- H, relapsed 2019
- Cause of Tinnitus
- noise-induced
Frequency posted this on their Twitter - a discussion on what the future of hearing loss treatment could look like and how it might benefit patients, with Carl LeBel. This was from the virtual Hearing Loss Association of America (HLAA) convention earlier this summer.
I really hope that FX-322 is the breakthrough they need to give ENTs a reason to actually focus more on the ear, and treat people.
This was a great interview. Tinnitus wasn't specifically asked about but it was interesting to have practicing clinicians on the panel with LaBel.
A few new points:
-There might be benefit even in patients who already have cochlear implants. One ENT or Otologist (can't remember which she was) pointed out that improved hair cell function sends signals to the auditory nerve and would improve auditory nerve function. Really interesting and something I had never heard before.
-Frequency Therapeutics was blinded in the last study until the completion. Since we can assume they are again blinded the same way, stock fluctuations and c-suite trading is probably completely meaningless in terms of the anticipated effectiveness of the drug.
-Hearing aids apparently suck so bad that only about 1 in 6 people use them even when they have bad hearing and even when they are free. Everyone on the panel agreed regenerative medicine will blow them out of the water.
-The clinician on the top left said she thinks people without much clinical hearing loss will benefit from regenerative medicine and she plans to use regenerative drugs in that population too. So for everyone worried doctors won't give them the drug with a normal audiogram, go see her at that point (I'm sure she wouldn't be the only one).
-Dr. LeBel said for sure they expect drug release this decade but wasn't able to say more than that conservative estimate. He did give a hint that people could use to "estimate a better timeline" (since he couldn't come out and give his own estimate) by saying cardiac drugs take 5 years for phase 3 but they are able to enroll hundreds (instead of thousands of patients) because there is zero concern to the FDA that hearing improvements could be placebo. I get that it means (much shorter) but what that means is anyone's guess).
Anything else I miss?
This COVID-19/Election Year 2020 mess creates a volatile stock market at times to no culpability placed on Frequency Therapeutics itself or even the bio-tech industry as a whole. FREQ will shine through and in a big way. I am quite confident and have no worries of my investment in this company.
I think that it can benefit people positively and I also actually think that it is a positive sign observing Frequency Therapeutics engage with many stakeholders. Still I feel that just like I explain below why doctors might be initially unwilling to treat patients, I also feel that there might be the same sort of apathy also from doctors.
If it is successful (and I think it will be successful), I believe that there will still be problems with convincing many ENTs to treat patients with FX-322 initially. I reckon that there will be a mixture of skepticism and refusal from some. Others however will obviously be willing to treat.
The most likely obstacle patients may face is finding a doctor who would be willing to work with them for the duration of their course of treatment. FX-322 is inevitably going to be a treatment that requires a lot of investigatory and also trial work to get the treatment right, especially in the initial stages. Thus this will not be something that many doctors will want to take on because it will be time consuming and not necessarily simple for them like deciding to do ear tubes. Furthermore it may be less financially beneficial for them when compared to other treatment options they could provide.
Thus I believe that until doctors either
- recognise the benefit in providing FX-322 treatment to people
or
- there are improvements in the ease of delivering FX-322 to patients and these improvements clearly result in the treatment becoming simpler to administer to people
There will be quite a lot of apathy for doctors to administer FX-322 or even learn about it so they can actually administer it.
For example doctors in Australia consistently refuse or resist to learn new procedures until there is a demonstrable benefit to them or some other reason for doing so. I assume this happens in other places also. As a result I feel that until Frequency Therapeutics can lay the ground work and actually convince doctors to treat using FX-322 there will be a barrier for patients to be able to obtain treatment.
- Sep 21, 2016
- 1,051
- Tinnitus Since
- 2011 - T, 2016- H, relapsed 2019
- Cause of Tinnitus
- noise-induced
I personally suspect that it could be much less than that - they can't really give away any official timelines and are probably erring on the conservative side for now, but LeBel's made it implicitly clear IMO that they are going to try and get this on the market as fast as possible. It was heartening to hear him say that the Phase 3 trials will probably be on the shorter side and don't require thousands of participants. The fast-track status and breakthrough therapy should also expedite things also I don't think this was mentioned in the interview. Plus, there's the possibility of compassionate use once this next phase is concluded.
He said that but almost gave a wink that you could use cardiac studies as a comparison to get a better timeline. It seemed like he had to say within a decade to be as conservative as possible without making promises while offering that cardiac study phase 3's take 5 years but theirs would be shorter. That's how I took that anyway.
- Feb 14, 2020
- 1,630
- Tinnitus Since
- 1-2019
- Cause of Tinnitus
- 20+ Years of Live Music, Motorcycles, and Power Tools
In 4 years, the pace at which FX-322 has gone from a publication in 2017 (Cell Reports) to a Phase 1 Trial, then a Phase 2 Trial (ending Q2,2021); it's hard to imagine the trials spanning out another 5 years, let alone 10.
LeBel also mentions that a Phase III would likely require "hundreds" instead of "thousands" of participants. So, I would anticipate recruiting being much less of an issue. Not to mention, increased awareness amongst doctors and patients.
- Aug 28, 2019
- 1,496
- Tinnitus Since
- -
- Cause of Tinnitus
- -
I must have missed that 10 years bit.
Goddamn, I will be 60 if it takes 10 years.
Let's hope it comes within 5. Got to think positive! It's all we've got.
- Apr 15, 2017
- 1,419
- Tinnitus Since
- 2008
- Cause of Tinnitus
- Noise
Any ideas, if FX-322 is successful, when will it be available on the market? I thought people were expecting 2023-2025 but is that hugely unrealistic?