Frequency Therapeutics — Hearing Loss Regeneration

#91
Frequency Therapeutics to Present at Cowen & Company 37thAnnual Healthcare Conference
http://www.businesswire.com/news/home/20170301005389/en/

"With the recent publication in Cell Reports of a study by our co-founders validating the Frequency Progenitor Cell Activation Platform, we are rapidly advancing toward in-human trials targeting cellular regeneration within the inner ear to restore healthy tissue and reverse hearing loss. We expect to be in the clinic within the next 18 months. We are looking forward to presenting at the Cowen & Company Healthcare Conference to educate new audiences about the Frequency story and platform."

Maybe we'll know more next week.
 
#92
Thanks for the article. I think everyone is looking too deeply into the 18 month thing. Its a year and a half. That's a nice round number. It could be 18 months two months from now or 12 months two months from now. They are going to aggressively pursue this though. They know Novartis has their hearing loss drug and it is hit or miss right now from the info we currently have, but probably a miss. If they can get this to market even with a 25 db improvement, its worth billions of dollars. That's motivation.
 
#96
Guys please read other threads before posting... This has been posted and discussed a dozen times and belong to the Frequency Therapeutics thread...
 
#97
VRZ78 said:
Guys please read other threads before posting... This has been posted and discussed a dozen times and belong to the Frequency Therapeutics thread...
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Most people dont think about it, most people get very hype when they see something like this :) and you cant really blame them for that :D
 
#98
Foncky said:
"We further tested the conditions using one sample of healthy human inner ear tissue isolated from a 40-year-old male patient undergoing a labyrinthectomy to access a tumor on the brain. The inner ear tissue was microdissected to remove bone, debris, and nerve tissue. The tissue was then treated identically to the mouse tissue to isolate single cells for culture. The single cells formed clonal colonies after 12 days under EFICVP6 conditions, although expansion was not as robust as that seen for neonatal cells (Figure 6Figure 6F). The colonies stained for Sox2, a known marker of inner ear progenitor cells (Figure 6Figure 6F). After 12 days of expansion, the cultures were treated with LY411575 and CHIR for 10 days to differentiate the colonies. The colonies stained positively for the hair cell marker myosin VIIa (Figure 6Figure 6G), suggesting that sensory epithelium from adult human inner ear can also give rise to hair cell progenitors."

We're almost "past" the mice stage.
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This is really positive news. I missed this. I'm in the US and I might be a good candidate for this trial. I am 50 db loss under 1k and 90-110db loss over 1k. I might be the perfect candidate. Even as bad as 50db is though, it is still huge and between hearing aides and some serious lip reading I get by ok. To lose my left ear completely would be a huge step back. I would guess they would want someone in the 80db loss range for under 1k.

My only concern is that they could be testing different volumes of liquid injected into the ear to determine what works best. This is where it gets tricky as too little or too much could have the opposite affect. This is something I believe could have been a factor in the Novartis trial and maybe it was the difference between people getting better hearing and people getting worst hearing after the procedure.

Either way, the more and more I read, the more I want to sign up for this trial. Thanks to everyone for the posts and information. This thread is really helpful.
 
#102
Samir said:
I can't seem to find the page now, but I think I read the other day that Frequency already has some kind of skin-related treatment ready for the market. I may have looked at a different company, I don't know. I will see if I can find it again. But you can tell by the paragraph above that they want to do more than hearing restoration.
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Correction! No, that was GenVec with their foot and mouth vaccine. The fact that Frequency Therapeutics also wants to move into other areas still remains.

Forgive me for bumping the thread! I just had to come back here and correct myself! :)

It's becoming difficult to keep track anymore who does what products and when. I have to get better organized. I'm not just saying it to get your hopes up, there really is a lot of activity going on. This is always a good thing when it comes to patients. (y)

I know of 12 companies thus far that are working on some kind of treatment for the inner ear. If it's not about regeneration, it's about protection. If it's not about hearing, it's about balance. I would say it's about bloody time! Because the lack of medical treatments in the field of otology has been allowed to go on for far too long.
 
#106
RB2014 said:
Thanks for the article. I think everyone is looking too deeply into the 18 month thing. Its a year and a half. That's a nice round number. It could be 18 months two months from now or 12 months two months from now. They are going to aggressively pursue this though. They know Novartis has their hearing loss drug and it is hit or miss right now from the info we currently have, but probably a miss. If they can get this to market even with a 25 db improvement, its worth billions of dollars. That's motivation.
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The cochlea is the size of a fingernail lodged deep in your skull, oh it's also wrapped in bone, a bony structure called the cochlea. If you think were going to get in there and find a cure you really must be having a miraculous life! Miracles, I don't believe in em.
 
#107
Ian Mac said:
The cochlea is the size of a fingernail lodged deep in your skull, oh it's also wrapped in bone, a bony structure called the cochlea. If you think were going to get in there and find a cure you really must be having a miraculous life! Miracles, I don't believe in em.
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Internet trolls, we don't need them. :troll: More importantly, we don't need the negativity. The human body is a complex machine. Curing hearing loss isn't a question of IF but WHEN.
 
#108
JRchief said:
Internet trolls, we don't need them. :troll: More importantly, we don't need the negativity. The human body is a complex machine. Curing hearing loss isn't a question of IF but WHEN.
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Yeah like he said, as is 100,000 years from now.. Miraculous to happen next year? Yes.
 
#109
Every time I open this forums I get more depressed, I'm feeling very sorry for us, while the time passes the less I see the light, the only thing we have is speculation and guessing, nobody knows what they are really doing, they been saying human trials in 18 months from last year, when the 18 months supposed to start? This year or next year or in 5 years, who knows.
 
#110
JRchief said:
Internet trolls, we don't need them. :troll: More importantly, we don't need the negativity. The human body is a complex machine. Curing hearing loss isn't a question of IF but WHEN.
Click to expand...

In case you didn't know, you can ignore him by clicking on his name and then on the Ignore button. There's no need to waste time with (bad) trolls like this guy.

Penate said:
Every time I open this forums I get more depressed, I'm feeling very sorry for us, while the time passes the less I see the light, the only thing we have is speculation and guessing, nobody knows what they are really doing, they been saying human trials in 18 months from last year, when the 18 months supposed to start? This year or next year or in 5 years, who knows.
Click to expand...

For God's sake, stop taking everything literally. It's a round number to make a press release easier. It could be 15 o 20 months. The point is they are fully committed to trial their approach soon.
 
#111
Ian Mac said:
Yeah like he said, as is 100,000 years from now.. Miraculous to happen next year? Yes.
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I don't see where the miracle is. They inject a liquid drug in your middle ear, and some of it reaches the cochlea. Finding the right drug is the challenge, not reaching the inner ear.

Put some neomycin drops in your middle ear and tell me about it. You will go deaf but at least, you'll know that the cochlea is easy to reach like that ;)
 
#112
Foncky said:
I don't see where the miracle is. They inject a liquid drug in your middle ear, and some of it reaches the cochlea. Finding the right drug is the challenge, not reaching the inner ear.

Put some neomycin drops in your middle ear and tell me about it. You will go deaf but at least, you'll know that the cochlea is easy to reach like that ;)
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Damaging the cochlea is a lot easier than repairing it apparently.
 
#113
Samir said:
I interpret this as if they will form synapses, but only if the SGN axon terminals are intact. How can they be? My understanding is that when a hair cell dies, the synaptopathy begins, followed by neuropathy. The last thing to go is the SGN. Thankfully these can survive for a long time. But they don't spontaneously reconnect to newly regenerated hair cell. So this is a missing bit of the puzzle.

After some reading, it appears to me that inner hair cells are more important for hearing than outer hair cells, followed by their synaptic preservation. We have plenty of outer hair cells, we can afford to loose a few here and there. But the inner hair cells and preservation of their axon terminals is most crucial.

I'm not sure exactly how the axon branching looks like and what nerve endings innervate the outer hair cells, but I know that for each inner hair cell there is one SGN (spiral ganglion neuron). So for 15000 of inner hair cells, there ought to be 15000 SGNs.

Like I said, thankfully SGN cell bodies survive for a long time. But we will need a way not only to regenerate new hair cells but also to regenerate nerve endings so that they may once again make a synapse with the brand new hair cells.
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Judging by what Libermann told me it's entirely possible to lose synaptic connections without haircell loss and vice versa. This to me explains why people with"perfect"audiograms suffer from T and H whilst others with profound hearing loss have no T whatsoever.
 
#114
bill 112 said:
Judging by what Libermann told me it's entirely possible to lose synaptic connections without haircell loss and vice versa. This to me explains why people with"perfect"audiograms suffer from T and H whilst others with profound hearing loss have no T whatsoever.
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This is exactly what I recieved from Libermann as well. If his theory is correct then it's not a hair cell loss responsible for T but synaptopathy (loss of synaptic connections) is the one to blame.
 
#115
acufenero said:
In case you didn't know, you can ignore him by clicking on his name and then on the Ignore button. There's no need to waste time with (bad) trolls like this guy.
Click to expand...
I bet he is secretly hopeful! :D He just got a bad attitude/habit/syndrome.

bill 112 said:
Judging by what Libermann told me it's entirely possible to lose synaptic connections without haircell loss and vice versa. This to me explains why people with"perfect"audiograms suffer from T and H whilst others with profound hearing loss have no T whatsoever.
Click to expand...
Yes, the now famous HHL! :) It's no understatement when I say that HHL is probably one of the biggest discoveries in this field of research in the last 10 years.

I interpret that as if you two exchanged some emails? Would you care to share the bits that support the possibility of synaptic loss without hair cell loss?
 
#116
Ian Mac said:
Yeah like he said, as is 100,000 years from now.. Miraculous to happen next year? Yes.
Click to expand...

No Miracles next year, or the year after, or the year after. Maybe if all goes well a 25db improvement in the next 6 years or so if this trial is successful. If you follow the Novartis trial some people gained some of their hearing back. Its possible they might have gained 25db in some of the frequencies. If you call this a miracle then it was yesterday not tomorrow.

I'm not overly optimistic, but my posts are usually pretty realistic. We get good news and bad news and even though we are still a ways away it seems like more good news is coming out than bad.
 
#117
RB2014 said:
No Miracles next year, or the year after, or the year after. Maybe if all goes well a 25db improvement in the next 6 years or so if this trial is successful. If you follow the Novartis trial some people gained some of their hearing back. Its possible they might have gained 25db in some of the frequencies. If you call this a miracle then it was yesterday not tomorrow.

I'm not overly optimistic, but my posts are usually pretty realistic. We get good news and bad news and even though we are still a ways away it seems like more good news is coming out than bad.
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I don't call that a miracle.
 
#118
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Samir said:
I bet he is secretly hopeful! :D He just got a bad attitude/habit/syndrome.


Yes, the now famous HHL! :) It's no understatement when I say that HHL is probably one of the biggest discoveries in this field of research in the last 10 years.

I interpret that as if you two exchanged some emails? Would you care to share the bits that support the possibility of synaptic loss without hair cell loss?
Click to expand...
He mentioned it rather briefly in one of our exchanges via email so I took the time to do my own research on the subject and found that it is not a myth, you can lose haircells without heavy synapse loss but this also works the other way round too, you can lose synapses without losing its corresponding haircell OR the the two can occur alongside one another.

To me at least this lifts a huge question mark over noise induced T and or H and hearing loss and is also why I heavily agree with Libermans findings and I'll explain why.

We see many people suffering from hearing loss with no T and we always ask why is that the case? Your degree of hearing loss does not equate how severe your T or H is so why is that? If T and H are a result of hearing loss then literally every person on this planet would have T but they don't and of course this just adds more confusion to an already confusing condition, but I think Liberman has found the answer. To me it points at another factor one not typically accounted for by most audiologists and that's a secondary hearing loss not currently detectable i.e hidden hearing loss. People with hearing loss and no T simply haven't lost their synapses, they remain intact and how does Liberman and Co know this? Simple, Cochlear implants.
A Cochlear implant simply would not work if these synapses or fibres were missing or damaged but they do work and that's a huge clue, if haircell loss meant synapse loss then a profoundly deaf person wouldn't be able to hear with a CI but they do! This shows that even after haircell death these fibres can remain intact regardless of the loss and I've read quite a few papers that have observed this during studies.


Then we move onto someone with perfect hearing but yet have T and H after a rock concert, all hearing tests show up normal and everybody scratches their head and blames the brain but rather simply these people have suffered a synaptic trauma(my term)and not a haircell trauma.
Their haircells recovered from the noise exposure but it's underlying synapses did not and this is where T generates from.This is not a myth either(see picture)haircells can survive a trauma but lose synaptic connections to the brain.

It's also entirely possible to lose both from an acoustic trauma so in summary,

-Normal hearing loss without T is haircell loss with no damage to underlying neurons

-T and H are a result of damage to these underlying neurons or synaptopathy

-The two can happen independently or occur alongside one another

To me this unraveled the mystery behind T and H, Liberman could be wrong of course but I heavily doubt it, it's too logical to ignore in my opinion.
 
#119
bill 112 said:
View attachment 12362 View attachment 12362 View attachment 12362
He mentioned it rather briefly in one of our exchanges via email so I took the time to do my own research on the subject and found that it is not a myth, you can lose haircells without heavy synapse loss but this also works the other way round too, you can lose synapses without losing its corresponding haircell OR the the two can occur alongside one another.

To me at least this lifts a huge question mark over noise induced T and or H and hearing loss and is also why I heavily agree with Libermans findings and I'll explain why.

We see many people suffering from hearing loss with no T and we always ask why is that the case? Your degree of hearing loss does not equate how severe your T or H is so why is that? If T and H are a result of hearing loss then literally every person on this planet would have T but they don't and of course this just adds more confusion to an already confusing condition, but I think Liberman has found the answer. To me it points at another factor one not typically accounted for by most audiologists and that's a secondary hearing loss not currently detectable i.e hidden hearing loss. People with hearing loss and no T simply haven't lost their synapses, they remain intact and how does Liberman and Co know this? Simple, Cochlear implants.
A Cochlear implant simply would not work if these synapses or fibres were missing or damaged but they do work and that's a huge clue, if haircell loss meant synapse loss then a profoundly deaf person wouldn't be able to hear with a CI but they do! This shows that even after haircell death these fibres can remain intact regardless of the loss and I've read quite a few papers that have observed this during studies.


Then we move onto someone with perfect hearing but yet have T and H after a rock concert, all hearing tests show up normal and everybody scratches their head and blames the brain but rather simply these people have suffered a synaptic trauma(my term)and not a haircell trauma.
Their haircells recovered from the noise exposure but it's underlying synapses did not and this is where T generates from.This is not a myth either(see picture)haircells can survive a trauma but lose synaptic connections to the brain.

It's also entirely possible to lose both from an acoustic trauma so in summary,

-Normal hearing loss without T is haircell loss with no damage to underlying neurons

-T and H are a result of damage to these underlying neurons or synaptopathy

-The two can happen independently or occur alongside one another

To me this unraveled the mystery behind T and H, Liberman could be wrong of course but I heavily doubt it, it's too logical to ignore in my opinion.
Click to expand...
How would you explain when some people lower or diminish T when they use hearing aids?
 
#120
spingee said:
How would you explain when some people lower or diminish T when they use hearing aids?
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Who said such stupid things, hearing aids never lower nobody tinnitus or diminish, the only thing hearing aids do is masking the noise for those who have mild tinnitus, unilateral and not hyperacusis, after a year or more using this crap because it was mild they get habituated and ho the hearing aids works, they confused.
 

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