My cochlear and vestibular thingy are both slightly malformed, I don't know anything about my hair cells.Do they know the cause? I think Decibel Therapeutics and Rinri Therapeutics are working on a couple of projects for those who are born deaf.
My cochlear and vestibular thingy are both slightly malformed, I don't know anything about my hair cells.Do they know the cause? I think Decibel Therapeutics and Rinri Therapeutics are working on a couple of projects for those who are born deaf.
Can't view it. Is there anything in there on growing support cells, or transplanting hair cells/support cells?Since we're discussing genetic/hereditary hearing loss, I wanted to link a webinar conducted by Medicines Discovery Catapult on Tuesday regarding cell and gene therapy approaches to hearing loss. This webinar includes a presentation by the founder of Rinri Therapeutics and other experts regarding stem cell and AAV methods.
The Emerging Hearing Medicines Landscape Webinar Series - Webinar 4: The Challenges and Opportunities for Emerging Cell and Gene Therapy Approaches to Address Hearing Loss
They grow pluripotent stem cells and convert them to either hair-like cells or auditory neurons.Can't view it. Is there anything in there on growing support cells, or transplanting hair cells/support cells?
I don't think we have the diagnostics to the determine cause of tinnitus yet, let alone which part of the cochlea is damaged. They select you based off how long you've had SNHL and an audiogram I think.Would being diagnosed with Outer Hair Cell Dysfunction increase one's chances of being selected for the FX-322 clinical trial?
I watched the entire presentation live -- I wish I had taken notes though. The "hair-like cells" cells sort of gives me pause since they may not be as good as "natural" hair cells?They grow pluripotent stem cells and convert them to either hair-like cells or auditory neurons.
Seems very unlikely. The part of your cochlea that FX-322 will help is is different and distinct from the part that regulates balance.Do you think FX-322 could also treat issues with balance?
Yeah, that terminology made me pause too. I think they can replicate what seems to be hair cells, but aren't 100% at establishing function such as having them act as OHC or IHC.I watched the entire presentation live -- I wish I had taken notes though. The "hair-like cells" cells sort of gives me pause since they may not be as good as "natural" hair cells?
Yeah, we don't want "hair-like cells," give me some damn new born stereocilia.I watched the entire presentation live -- I wish I had taken notes though. The "hair-like cells" cells sort of gives me pause since they may not be as good as "natural" hair cells?
Damn. I had good balance before I lost my hearing!Seems very unlikely. The part of your cochlea that FX-322 will help is is different and distinct from the part that regulates balance.
I believe this is a more scientific way of looking at it. They can observe these cells as exhibiting the characteristics of hair cells (as we understand) but in the end they cannot conclude with certainty that they are exactly the same.Yeah, that terminology made me pause too. I think they can replicate what seems to be hair cells, but aren't 100% at establishing function such as having them act as OHC or IHC.
Yes, I could be wrong but I do think when a drug is ototoxic it causes some damage.FX-322 regrows hair cells so it will help if you have hair cell loss. It's not a general tinnitus drug.
Hair cell loss isn't the mechanism of action for benzo induced tinnitus. However, if you had hair cell loss and the benzos worsened the tinnitus from the structural deficit, I could see it being helpful.
CT brain scans show a difference in ventricular cerebral spinal fluid space dimensions between benzodiazepine users and non-users, and also between high and low benzodiazepine users.Correct, which is why benzos aren't technically considered ototoxic.
Oh it's definitely neurotoxic but not classically "ototoxic" in the strict sense.CT brain scans show a difference in ventricular cerebral spinal fluid space dimensions between benzodiazepine users and non-users, and also between high and low benzodiazepine users.
Benzos can be very ototoxic on hearing with withdrawal from use as Frequency Therapeutics is well aware of.Oh it's definitely neurotoxic but not classically "ototoxic" in the strict sense.
I fully agree with you. They wreak havoc on the auditory system with tolerance or withdrawal.Benzos can be very ototoxic on hearing with withdrawal from use as Frequency Therapeutics is well aware of.
I would need to post more than one-liners with data to explain about withdrawal from use, but not feeling well to do so.
I would like to give you a hug for all your outstanding contributions.
It's pretty crazy, I know. But I think that for these professionals who mostly deal with people struggling to communicate verbally with others at all, children developing language skills in spite of major hearing loss and so on, the frequency range of the human voice is what seems important. Hearing loss above that pretty much mostly becomes a major problem for us unfortunate enough to get tinnitus because of it or music lovers. Learning about what audiologists are trained to deal with makes my problems seem small in comparison. But it has still ruined my life so there's that, comparison doesn't change that or make it any less of a problem for me and my loved ones...It's just crazy how an audiologist can tell you that frequencies above 8 kHz are irrelevant to your hearing when it's information that can be readily accessed on Google.
My AuD legit told me it didn't matter; I think this is the case for many people here as well.
Could you explain more about how Frequency Therapeutics is aware of this?Benzos can be very ototoxic on hearing with withdrawal from use as Frequency Therapeutics is well aware of.
I would need to post more than one-liners with data to explain about withdrawal from use, but not feeling well to do so.
I would like to give you a hug for all your outstanding contributions.
The audiology profession is very interesting with what work they do. They totally tend to claim that sounds above 8000 Hz are irrelevant etc along with a whole load of other claims which don't stack up either. Essentially I have found that multiple audiologists are also very guarded and defensive when they are challenged on what they are claiming and presenting.It's pretty crazy, I know. But I think that for these professionals who mostly deal with people struggling to communicate verbally with others at all, children developing language skills in spite of major hearing loss and so on, the frequency range of the human voice is what seems important. Hearing loss above that pretty much mostly becomes a major problem for us unfortunate enough to get tinnitus because of it or music lovers. Learning about what audiologists are trained to deal with makes my problems seem small in comparison. But it has still ruined my life so there's that, comparison doesn't change that or make it any less of a problem for me and my loved ones...
The best resource is Frequency Therapeutics' most recent overview presentation:Can I ask that someone gives me a short version of what's going on with FX-322? I haven't read about this at all, do you think they really are on to something here?
> Phase 1/2 was only one dose/shot and it showed both non statistically significant and statistically significant improvement in word recognition and also statistically significant improvement in hearing volumes as well. We were also shown the medicine has been fairly safe thus far.Can I ask that someone gives me a short version of what's going on with FX-322? I haven't read about this at all, do you think they really are on to something here?
Excellent summary. However, it stands to reason that Frequency Therapeutics will, at the very least, report on the Primary Outcomes at the 90-day analysis of the Phase 2A in Q1 2021.> Phase 1/2 was only one dose/shot and it showed both non statistically significant and statistically significant improvement in word recognition and also statistically significant improvement in hearing volumes as well. We were also shown the medicine has been fairly safe thus far.
> Phase 2a is ongoing now and is a multi dose clinical trial with a readout of 90 day results due in March. This is 90 days from the time that the last patient got doses. The final Phase 2 results will be out in July next year.
> Frequency Therapeutics has expanded the scope of the clinical trials to test other categories too such as severe and age related hearing losses. These will be scheduled to be concluded around the same time as they will complete the noise phase 2a trial.
> The thought that Frequency Therapeutics has is that they will then proceed to Phase 3 according to Loose, their Chief Scientific Officer.
> The treatment has shown in the trials conducted in the lab that it is able to offer full regrowth across the board.
> Secondary measures such as speech in noise, tinnitus are being evaluated during this trial. There is no indication if it is going to be mentioned as part of the 90 day read out material or not, so this will mean that this then shall become part of the full trial outcomes.
> Frequency Therapeutics seems to be operating on a method of getting the treatment working now and showing it improves people's hearing to pass the FDA requirements and then look to improve the dosing later. This could be by basically doing more than four injections or looking at redosing after the clinical trial is done due to the fact that this means that they then do not need to revisit all aspects to pass the clinical trial.
> There is reasonable evidence that Frequency Therapeutics is onto something positive with FX-322 as so far they have demonstrated that the medicine can breach the blood barrier in the ear, that the medicine doesn't cause cancer like growth and that the medicine is effective at providing regrowth. These are all the factors that have alluded treatment in the past.
> Thus while we will need to wait for final results to come out, there is a lot of promise that this treatment will work and will provide benefit, and the evidence thus far demonstrates that it will.
I agree that frequencies up to 8 kHz are important for speech but, everything above 8 kHz still heavily affects it as well.It's pretty crazy, I know. But I think that for these professionals who mostly deal with people struggling to communicate verbally with others at all, children developing language skills in spite of major hearing loss and so on, the frequency range of the human voice is what seems important. Hearing loss above that pretty much mostly becomes a major problem for us unfortunate enough to get tinnitus because of it or music lovers. Learning about what audiologists are trained to deal with makes my problems seem small in comparison. But it has still ruined my life so there's that, comparison doesn't change that or make it any less of a problem for me and my loved ones...
I think the main issue is that they mainly deal with hearing aids, and that they only work up to 8000 hz Hz far as I know. The audiologists working "on the floor" probably have a narrow view of things.I agree that frequencies up to 8 kHz are important for speech but, everything above 8 kHz still heavily affects it as well.
It doesn't matter, in about 10 years with new surgeries and regenerative medicine most audiologists will be panhandlers or working at Burger King.