It always gets destroyed where electrodes are placed. They are attempting to preserve other areas by reducing inflammation as much as possible. That's one reason newer CIs sound better. They are shorter and preserve more natural low frequency hearing.
I assume you mean genetic and not congenital since it was fine until 25. It would depend on your cause.
They're also growing implantable hair cells, which is what I'm referring to. FX-322 should cover almost everyone's needs but it never hurts to have many working solutions for a problem or at least a backup.
You don't. Support cells are very durable and stick around long after a hair cell has died. Support cells can still die if exposed to continuously loud noises or under other conditions. The general consensus is the less hearing loss you have the more support cells you'll likely still have, so as long as you don't have profound hearing loss you likely still have support cells.
But they have said that each support cell divides when activated to produce a new support cell and a hair cell. There should be no net increase in this case.
I understand. However if tinnitus is your main concern, then you should still be good I think because you would just need to repair what you have lost during your lifetime.
A researcher that I emailed told me support cells die after all inner and outer hair cells are lost and this occurs in the profound range (>90 dB) and only in those areas of the cochlea.
If they get positive results in their Phase 2a clinical trials then they will definitely get Breakthrough Therapy status but we're not sure how much time gets shaven off once they get it.
Maybe. I feel like with the COVID-19 vaccine coming out so soon the FDA may show a lenient approach to FX-322. Remember there is no drug that can improve hearing but so far FX-322 has shown improvements with one dose. Both Frequency Therapeutics and the FDA will want FX-322 come out as soon as possible if it has a chance at improving someone's hearing.
Thanks for your reply frpp. My tinnitus started three months ago, caused by COVID-19, along with hearing loss at 3-4 kHz as in the picture... I hope I at least saved the support cells.
I read somewhere that support hair cells depletion occur in the severe range, i.e. between 70 dB and 90 dB.
I'm confused. Does it mean, say 4 kHz support hair cells, could divide and fill another frequency's hair cells?
This makes much more sense now, thanks. This too would be a wonderful outcome and actually also provide a good hybrid solution where appropriate.
Are you referring to the Investor Deck?
I used to be on this thread a couple of years ago and they've always grown back slightly odd. That doesn't mean they aren't fully functional. Especially due to the progress we've seen time and time again in their clinical trial phases. If they are confident in the functionality and longevity of the hair cells, then we don't have a reason to question it.
That makes sense. I have seen that before for OTO-6xx.
Any chance you were looking at the Audion thread instead since it was much more active "a couple of years ago?"
Thank you for the response. It will be interesting to see the latest data from the trials.
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