The other question is what is tinnitus in this context? If getting the 20 second transient tinnitus thing counts then sure, but if we are talking about chronic tinnitus I think this number is much lower.
Yes, very high pitch. In response to another post about what causes some people with hearing loss to develop tinnitus and others not, I've read that there could be a gene involved in those of us who develop tinnitus.
The general context seems to be of a chronic form, not the fleeting form. To clarify, I tend to think the chronic form + no hearing loss on the standard audiogram is much higher than reported.
Spectrally uneven audiograms and quickness of trauma may be inter-related. I would imagine a "very slow grind over time" to a wide variety of sound in life is going to wear on your hearing more evenly across frequencies, except in situations like factory work where you are near machines that constantly whine and hum at the same frequencies day in and day out. A sudden trauma might be more likely to make holes, dips, and drop-offs in narrower ranges.
So far, nothing, because of how far into the cochlea the gel would need to go—BUT—the trial results currently being anticipated will show the effects of multiple doses for the first time, and the hope is that this will get the treatment further in and help further down the range.
Nobody here has insider information. FX-322 repairs synapses where cells are regrown, but does not re-synapse healthy cells. Frequency Therapeutics has made no mention of a synaptopathy drug.
They have outlined possible future applications of their PCA platform, e.g., multiple sclerosis and alopecia. However, no mention of synaptopathy. Since PCA is based on activating the dormant progenitor cells, I am unsure how this would work for synapse loss since we're talking about the loss of neural connections here. To be honest I am not sure if we would get a synapse drug from them.
This current trial is to see if more doses reaches those lower frequencies.
They've referred to SNHL caused by ototoxic drugs, so regardless of the cause of SNHL, FX-322 should still treat the condition.
This was asked on the Tinnitus Talk Podcast, they didn't see a reason it wouldn't. To bolster that, it's not an exclusion factor in the severe trial.
It was low volume, though it was unusual. On another board I frequent they attributed it to a popular investor from Twitter who tweeted about it late in the day. If you search Twitter for the cashtag $FREQ, you'll see a post where a guy says he added some $FREQ. He has around 500k followers.
The recent run is probably because Oppenheimer issued new price targets 2 days ago so more people are buying in.
Using headphones while editing video and audio. I think it was the beeps from the mic-recorder, it would make when turned on, that did it for me.
Some do after massive OHC and IHC loss. This would put people in the profound range. I'm not aware of one that preferentially destroys them.
Hopefully they show real gains in the actual frequencies measured in the audiogram along with huge gains in the extended audiogram. It would seem that the gel getting into the round window would fully restore the high frequencies being there is a massive concentration of the stuff there. Hopefully they figure this out.
Yes, and that's the range that's bothering me the most. I could tolerate all the lower stuff for a much longer time. I believe if I could get my 9 kHz to 20 kHz back (imagine 20 kHz, haven't had that since I was a kid! Bonus!), just having that information coming in again would stop my brain from thinking it has to replace missing information with false information. And even if some of the ringing lingered, having hearing up there would mean I could actually mask it. (You can't mask a 14 kHz ring with noise centered around 6 kHz... it just doesn't work.)
A stretch but... 4 green checkmarks on the computer screen is probably a good signThis photo was posted on Frequency Therapeutics' Twitter on the February 10th, 2021. Can anyone find any clues about the upcoming results?
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. He's wearing Cowen swag which could suggests he's looking forward to presenting again this year.
I wish I had the presence of mind to do the kind of work he is doing.This photo was posted on Frequency Therapeutics' Twitter on the February 10th, 2021. Can anyone find any clues about the upcoming results?
I hope we have that again. I had a crack in the clouds yesterday where I felt like myself for a couple hours, had a favorite song in my head, was cracking little jokes to myself... it was like the universe hadn't completely abandoned me. I want that person back.
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