Based on my own observations here on this forum, earbuds / headphone use is certainly a common complaint for new users first discovering their tinnitus. Considering the recent growth in popularity of wireless earbuds like AirPods, and that usage of headphones has occurred at a younger age for the more recent generation, this isn't a surprise.
I can imagine constant AirPod/earphone usage due to working from home/Zoom classes and meetings can't be great for people's ears.
That's pretty amazing. You must have normal hearing above 8 kHz then. Have you ever had an extended audiogram?
Looking online, it looks like you should be able to just open a brokerage account with a company like eTrade, Robinhood, Webull, etc, and then just buy the stock like a US citizen would.
Same with me. -65 dB at 3 kHz & 4 kHz, yet have a 100% word recognition score. I still can hear pretty well with the speech in noise. I have only been tested up to 8 kHz, but I know I can't hear past 12 kHz in both ears.
Must be a collaborative effort then
What caused your hearing loss?Same with me. -65 dB at 3 kHz & 4 kHz, yet have a 100% word recognition score. I still can hear pretty well with the speech in noise. I have only been tested up to 8 kHz, but I know I can't hear past 12 kHz in both ears.
Must be a collaborative effort then
Acoustic Neuroma on left 8th cranial nerve. Having consulted with various specialists, the sudden loss that I experienced last October could be from nerve damage, toxic secretions from tumor or compromised blood flow. I'm not sure myself but holding out hope that since it was sudden, that it may have been toxic secretions affecting the cochlea.
Where have they said this? My understanding is that they consider test variability between re-taking WR/WIN tests as 3 words*. See bottom right of slide below.
The graph is entitled as clinically meaningful improvement. The sidenote about test variability on the bottom right doesn't mean clinically meaningful improvement = test variability (i.e. 3 words). The purpose of that is to show transparency in their methodology and how one standard deviation translates in real terms as a reference point.
Exactly. Those that had clinically meaningful improvements scored beyond a single standard deviation (6+ words would be 2 standard deviations). Confirming the improvement wasn't variability.
The average person also thinks that loudness hyperacusis is just the volume being turned up. It's so much more -- the brain completely rejects sound like an allergy.
Would this suggest that the hair cells die off again as time goes by?
No never, only up to 8000 Hz.
I do like the fact that they are promoting on Twitter improvement with background noise speech interpretation, because in small loud restaurants I struggle bad. Have to read lips even. Sucks...
So far it has been proven that FX-322 works and show word score improvements on the audiogram.
They showed small improvements in Phase I/II at 8 kHz. I think there will be better improvements at the 12 kHz and 16 kHz bands, and I also think we'll see a bigger improvement at 8 kHz for the multiple doses.
It's good to Google some brokers based in France.
I would think it's more due to older hair cells dying off that were still there at the time of the injections? New hair cells will wear for sure, but I'd expect it to take more time.
This comment is really important, and why their Twitter feed and messaging tends to focus on the hearing loss challenges of the patient. The typical person doesn't go through their day "gee, I think I'm deficient at 4 kHz on the audiogram"... they say, "I can't hear while in noisy restaurants" or "I don't understand conversations as well."
I feel like anything on the extended audiogram is not going to be considered important. You have to remember doctors at the FDA are going to scrutinize the shit outta this. They are going to say frequencies outside of speech range don't matter. Remember you have idiots like Julian Cowan Hill who want this to fail so he and his cronies can keep screwing the system.
If they successfully make the case that the higher frequencies make a difference in word scores and co-relate the two, I'm confident the drug would still be released. It might just have less of a market share.
From what I'm understanding, you're essentially getting the same hardware that you got in the womb. So, yeah it's going to take a while for the new hair cells to noticeably wear from a performance perspective, but they aren't any more durable than the original equipment you got at birth.
Not saying they're more durable, but if a hair cell can take, say, 40 years of a certain amount of "abuse," then assuming that person isn't subjecting their ears to anything worse, the shiny new hair cells should have more life on them than the older ones. Like mileage on a car.
Currently, the FDA has granted the drug the Fast Track Status, which based on the Phase 1 and 1/2 data, they have indicated that FX-322 meets ONE or MORE of the following criteria:
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