I hope this isn't coming across as me making light of the situation... I, like several others, did not have high hopes for greater penetrance (although a part of me was really hoping they'd push to 5 kHz or so with repeat dosing), but I truly thought there would be 30-40 dB gains in the EHF and 15-20 around 8 kHz.
I considered this to be a decent first pass at a revolutionary drug, and I'm just feeling deeply deflated that we didn't even see that. So I seek refuge in the memes.
I still think there is something missing from this puzzle, that isn't completely accounted for even if those with severe HL had been given the placebo arm in phase 1 and shown the same improvements as the treatment arm.
As someone who experienced short lived hearing loss and muffedness in my right ear it's difficult to imagine jumping from 30 words on the WRT, to 60 - all from the placebo effect. Hearing loss is very difficult to hack in that way. You kind of don't hear the words or you do.