Frequency Therapeutics — Hearing Loss Regeneration

[Diesel]

Some users will shoot me dead, but I consider the current formulation of FX-322 to be like an attempt at a small cure. I think the difference between a treatment and cure is that a treatment is intended on covering up a problem.

I'd meet you halfway and agree to that term, "Small Cure" ... since it really only fixes one of the many underlying causes of SNHL.

 

[FGG]

I didn't realize it's also an NDMA antagonist. That's great.

It's not. It doesn't bind to the receptor. It reduces excitation at the receptor, though:

The neuroprotective agent ebselen modifies NMDA receptor function via the redox modulatory site

 

[Tezcatlipoca]

It's not. It doesn't bind to the receptor. It reduces excitation at the receptor, though:

The neuroprotective agent ebselen modifies NMDA receptor function via the redox modulatory site

That'd be enough to help though, right?

 

[Lucifer]

Their tinnitus is from sudden hearing loss. Not noise.

I know, but I thought the reason why his tinnitus might have come back was because he was exposing himself to loud noise.

 

[FGG]

That'd be enough to help though, right?

That's the hope and there is definitely good potential with the drug. I think some people will have a greater response than others, though.

 

[VeryUnfortunate]

So when's the next big date on results for FX-322?

 

[weab00]

So when's the next big date on results for FX-322?

Sometime in Q3, probably June-August.

 

[Zugzug]

So when's the next big date on results for FX-322?

Probably late Q2: ARHL and Severe arms.

 

[Street Novelist]

So when's the next big date on results for FX-322?

Supposedly in June.

 

[Chad Lawton]

How many people go to the doctor and say they have perfect hearing and they just have trouble understanding a few words... It is a very small subset of people.

Of those that improved in the Phase 1/2 trial, their WR scores were on average 25 or less out of 50. That means they can only hear half the words in a conversation or less. It's absolutely life changing to go from understanding only 1 out of every 3 words in a conversation to hearing 2 out of every 3 words.

 

[d'Wooluf]

Hence my objection to this spin that we should pay attention to modest improvements in WR scores and disregard unchanged audiograms.

I was hoping for both but I broadly agree with you. It was such a smooth change of emphasis we pretty much all bought it. I was hoping to throw away my hearing aids. But if FX-322 or some other treatment doubled my WR scores, that would still make a huge difference to my life.

 

[Gb3]

Does anyone care about tinnitus anymore?

 

[RB2014]

Does anyone care about tinnitus anymore?

If FX-322 can restore hearing 8 kHz and up, there is a good chance this could help people with high frequency tinnitus. We are just waiting for more results to come out.

 

[RB2014]

I was hoping for both but I broadly agree with you. It was such a smooth change of emphasis we pretty much all bought it. I was hoping to throw away my hearing aids. But if FX-322 or some other treatment doubled my WR scores, that would still make a huge difference to my life.

Agreed. When this whole thing started, I was hoping to throw away my hearing aids as well. At this point it looks like we might get some hearing back in the 8 kHz range, get better word scores and keep our hearing aids. I am ok with that.

 

[Zugzug]

Does anyone care about tinnitus anymore?

Yes. We just recognize that it's an ugly path forward with incremental progress. Trust me, I know all about long-haul thinking. My reason for following FX-322 is that I want it to succeed so that their nerve regeneration drug has a better chance. This is a decade+ long vision. It sucks, but it's reality, whether we accept it or not.

And BTW, there really are some promising treatments for tinnitus.

 

[Guywithapug]

If FX-322 can restore hearing 8 kHz and up, there is a good chance this could help people with high frequency tinnitus. We are just waiting for more results to come out.

Yes, I would like to know more about the quality of the restoration. Metrics of how far up beyond 8 kHz and to what degree in terms of dB gain. Was there significant tinnitus relief? Also, what is the longevity of said restoration?

 

[ThomasRobert]

Yes, I would like to know more about the quality of the restoration. Metrics of how far up beyond 8 kHz and to what degree in terms of dB gain. Was there significant tinnitus relief? Also, what is the longevity of said restoration?

 

[Bill Arsenault]

Does anyone care about tinnitus anymore?

Ever having any choice again whatsoever is so 2019.

 

[Diesel]

Now that the multi-dose door is closed for the foreseeable future, I wonder if they are considering a trial where both ears are given a single dose?

 

[Lurius]

If FX-322 can restore hearing 8 kHz and up, there is a good chance this could help people with high frequency tinnitus. We are just waiting for more results to come out.

What about 6 kHz? Any hope for people with hearing loss in that range?

 

[kiki]

Now that the multi-dose door is closed for the foreseeable future, I wonder if they are considering a trial where both ears are given a single dose?

What are the benefits of injecting into both ears?

Will the effect be greater?

 

[Tezcatlipoca]

What are the benefits of injecting into both ears?

Will the effect be greater?

Well many members on this forum have always complained that usually only one ear is treated, so at least those people will be content.

I think injecting into both ears can be beneficial.

 

[kiki]

What about 6 kHz? Any hope for people with hearing loss in that range?

Certainly, in the patent application, I think that there were two 5 dB improvements at 6 kHz in Phase 1/2.

 

[MrCrybaby]

What are the benefits of injecting into both ears?

Will the effect be greater?

One hypothesis of tinnitus is asymmetrical hearing damage that the brain tries to balance out unsuccessfully. Treating both ears could address this potential mechanism of action.

 

[Gb3]

What about 6 kHz? Any hope for people with hearing loss in that range?

No one knows if the drug works like they initially said.

 

[Gb3]

What are the benefits of injecting into both ears?

Will the effect be greater?

The results will be all over the place. They won't do that.

 

[Diesel]

The results will be all over the place. They won't do that.

Why do you think this?

 

[Gb3]

Why do you think this?

The whole point is just to prove its efficacy to get past the clinical trials. I think doing two ears is just harder to gather all the data, too many variables. If you have noticed, all the trials related to hearing treatment focus on one ear. That's not saying it won't work for both. It's just easier to establish the endpoints for the trial when it is about one ear.

 

[Tezcatlipoca]

It's just easier to establish the endpoints for the trial when it is about one ear.

But all current existing measurements of hearing rely on both ears...

 

[Gb3]

But all current existing measurements of hearing rely on both ears...

They measure each ear separately.