Frequency Therapeutics — Hearing Loss Regeneration
- Thread starter RB2014
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My question was if this vídeo and article has been updated after or before the 1/2 trial beginning.
Hope remains for us human beings.
There are many questions and warnings. For example, it is known that if the outer hair cells of the ear die, this is displayed on the audiogram as a loss of the sound sensing thresholds by about 50 dB.
Many here have much less damage, for example, at 14 kHz, the decrease in the perception of the sound senses by 25 -30 dB. This means that the external hair cells themselves are alive, but they are damaged and can not function adequately.
Can technology from "Frequency Therapeutics" help in such cases? Not growing new outer hair cells, but repair, bring the damaged cells to perfect condition?!
In addition, some kind of partial regeneration is possible. But is it 100% complete? Perhaps "Frequency" will be able to return some acceptable thresholds in severe cases, but whether they can return the original ideal hearing is a question mark. Only then will the tinnitus completely disappear. Any loss of sound perception, even by 15 -20 dB, will force the brain to give these spontaneous impulses.
In addition, to be honest, it is unclear how the substance, when introduced into the middle ear, will penetrate into the inner ear, or rather into the cochlea. The cochlea is not a muscle or nervous tissue through which substances can easily penetrate. The cochlea is bone tissue.
As far as I understand, the experiments were carried out only in vitro. But will these results be the same when tested in vivo, that is, in the living body of a person?
Indeed, it is very unlucky that the ear is protected by such a thick bone system.
There are many questions and warnings. For example, it is known that if the outer hair cells of the ear die, this is displayed on the audiogram as a loss of the sound sensing thresholds by about 50 dB.
Many here have much less damage, for example, at 14 kHz, the decrease in the perception of the sound senses by 25 -30 dB. This means that the external hair cells themselves are alive, but they are damaged and can not function adequately.
Can technology from "Frequency Therapeutics" help in such cases? Not growing new outer hair cells, but repair, bring the damaged cells to perfect condition?!
In addition, some kind of partial regeneration is possible. But is it 100% complete? Perhaps "Frequency" will be able to return some acceptable thresholds in severe cases, but whether they can return the original ideal hearing is a question mark. Only then will the tinnitus completely disappear. Any loss of sound perception, even by 15 -20 dB, will force the brain to give these spontaneous impulses.
In addition, to be honest, it is unclear how the substance, when introduced into the middle ear, will penetrate into the inner ear, or rather into the cochlea. The cochlea is not a muscle or nervous tissue through which substances can easily penetrate. The cochlea is bone tissue.
As far as I understand, the experiments were carried out only in vitro. But will these results be the same when tested in vivo, that is, in the living body of a person?
Indeed, it is very unlucky that the ear is protected by such a thick bone system.
Does anyone have an opinion on the ethics of what Frequency Therapeutics is doing here?
They build on the work of scientists who went before them. They do the groundwork in labs that are funded by either the government or charitable donors. Their pay is from the same sources. In their research, they use body parts from people who donate their bodies to 'science'. And then when they get close to something that may work, they do this:
They squirrel it away, don't share it with other scientists. In fact they patent everything that they can, so other scientists can't help progress their work. They start up their companies with the aim of making squillions of dollars. They talk up their work- not for the benefit of you or me- but to attract potential donors and possible buyers of their intellectual property. By talking up their work, they raise hopes in people like you and me. If it doesn't work, no great problem. They've still got their university jobs. On they go to the next project.
I can already hear you say that you don't care as long as they can cure your f-ing tinnitus. Maybe you should care. Maybe these guys are actually holding things back more than moving things forward. It just seems weird to me.
They build on the work of scientists who went before them. They do the groundwork in labs that are funded by either the government or charitable donors. Their pay is from the same sources. In their research, they use body parts from people who donate their bodies to 'science'. And then when they get close to something that may work, they do this:
They squirrel it away, don't share it with other scientists. In fact they patent everything that they can, so other scientists can't help progress their work. They start up their companies with the aim of making squillions of dollars. They talk up their work- not for the benefit of you or me- but to attract potential donors and possible buyers of their intellectual property. By talking up their work, they raise hopes in people like you and me. If it doesn't work, no great problem. They've still got their university jobs. On they go to the next project.
I can already hear you say that you don't care as long as they can cure your f-ing tinnitus. Maybe you should care. Maybe these guys are actually holding things back more than moving things forward. It just seems weird to me.
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Somebody with negative experience with the trial.
Getting a few messages in my inbox what the source is: https://www.reddit.com/r/tinnitus/ (obviously
)I think this is great news! He has given up as he doesn't want to take the risk of having placebo and wasting his time.
Advertising/PR is an important function. People around the world get paid a lot of money for no value added other than to promote an item.
One important item you left out was their papers to science journals. Whether they have patent or not the dissemination of their research and results in a peer reviewed journal is a public good.
ManagerNot to mention his money. He was also concerned about acquiring additional hearing loss (presumably from the injection).
Rubenslash
Member
Street Novelist
Member
- Apr 2, 2018
- 290
- Tinnitus Since
- February 2018
- Cause of Tinnitus
- Listening to loud music through headphones
I went through his post history and apparently his main problem was the location being in a "ghetto". Here is the facility for anyone interested.
https://www.google.com/maps/place/Worldwide+Clinical+Trials/@29.5163711,-98.4169658,3a,87.8y,355.83h,83.4t/data=!3m6!1e1!3m4!1sSIaAIGq5gG_7dNREYYIkYg!2e0!7i13312!8i6656!4m13!1m7!3m6!1s0x865cf4b5e81c44cb:0x9a006f8170d58d8f!2s2455+NE+Interstate+410+Loop+#150,+San+Antonio,+TX+78217!3b1!8m2!3d29.517151!4d-98.417066!3m4!1s0x865cf4b5e81c44cb:0x65dff9b97bdb3a2a!8m2!3d29.5170726!4d-98.4170522
The google reviews aren't very promising...
- May 7, 2015
- 1,045
- Tinnitus Since
- 29.09/2014
- Cause of Tinnitus
- Acoustic trauma using headphones
- May 7, 2015
- 1,045
- Tinnitus Since
- 29.09/2014
- Cause of Tinnitus
- Acoustic trauma using headphones
I read an article on lthe clinical trial industry in San Antonio. Apparently it's huge. Most of the participants are from the lower socio-economic end of town who use the payments they get (for the risks they take) to supplement their incomes. It's a bit sad and scary really. I'm not surprised the facilities aren't salubrious.
Valid points. It still seems strange that you can get paid by an institution to do research and then take the intellectual property with you. I'd love to see their contracts. And I still think they are at the pointy end of a lot of research. Does the poor guy who did research ten years ago and published a paper that led to another that got Jeffrey Karp or whoever thinking... does that guy get a slice of the action?
I went through his posts too. He hates this board. Thinks it's negative. Can't work out why...
If the Google reviews are any indication, the trial facility is horrendous. So I mean what's up with the fact that FX Therapeutics is conducting their trial in such a facility.
Aren't the trial contracted out to reach more people though? Is just one facility that does a number of clinical trials? Correct me if I'm wrong.
FX Therapeutics is a research company.
They are not interested in nor probably have the capacity to perform clinical studies on their own.
Recruiting, screening and monitoring is a huge task with regulations and risks involved, so it is outsourced to an external company. It was mentioned that this business is based on people taking part in studies for financial reasons.
Note that this study phase has a risk involved, your hearing might be impaired or changed forever.
Facility is huge and perform multiple tests, having perfect conditions and care would skyrocket the study costs.
In the end it's all about the money really.
FX is patenting inventions but otherwise how would they make any profit out of their work? They will most probably not produce, market nor sell it - just license to pharma companies.
And yes according to their webpage they paid the previous work by licensing from MIT.
Let them do what they're best at - research.
They are not interested in nor probably have the capacity to perform clinical studies on their own.
Recruiting, screening and monitoring is a huge task with regulations and risks involved, so it is outsourced to an external company. It was mentioned that this business is based on people taking part in studies for financial reasons.
Note that this study phase has a risk involved, your hearing might be impaired or changed forever.
Facility is huge and perform multiple tests, having perfect conditions and care would skyrocket the study costs.
In the end it's all about the money really.
FX is patenting inventions but otherwise how would they make any profit out of their work? They will most probably not produce, market nor sell it - just license to pharma companies.
And yes according to their webpage they paid the previous work by licensing from MIT.
Let them do what they're best at - research.
We are obliged to firmly cross fingers and make pleas to the sky, in order for Frequency Therapeutics to succeed and everything to go right.
This is truly a blessing for us.
What are they trying to do? - Frequency therapeutics is today a revolutionary company that wants to experience a revolutionary regeneration technology. They have their own vision and their own separate mechanism of action for a treatment.
They do not want to spend decades studying each individual gene, as they do in Geller's lab. They immediately want to create a revolution in the world of regeneration, and they choose the method of action. Trial and error method.
In their team, brilliant scientists, such as Dr. Robert Langer and others.
What they are doing is walking along the edge of the abyss. But if they succeed, this will be one of the most significant breakthroughs in the 21st century.
We will cross our fingers and pray to the heavens so that everything will be fine.
This is truly a blessing for us.
What are they trying to do? - Frequency therapeutics is today a revolutionary company that wants to experience a revolutionary regeneration technology. They have their own vision and their own separate mechanism of action for a treatment.
They do not want to spend decades studying each individual gene, as they do in Geller's lab. They immediately want to create a revolution in the world of regeneration, and they choose the method of action. Trial and error method.
In their team, brilliant scientists, such as Dr. Robert Langer and others.
What they are doing is walking along the edge of the abyss. But if they succeed, this will be one of the most significant breakthroughs in the 21st century.
We will cross our fingers and pray to the heavens so that everything will be fine.
There is only one question that is unlikely to be answered. One fear.
Regeneration implies dead outer hair cells, which on the audiogram is roughly displayed as a drop in perception of 50 dB.
But if someone has not a dead hair cell, but only a damaged one, which on the audiogram is displayed approximately as a drop in the perception of 30 dB.
Can this regeneration technology help in such cases? Meaning to restore the damaged cell, and not to grow a completely new one.
Regeneration implies dead outer hair cells, which on the audiogram is roughly displayed as a drop in perception of 50 dB.
But if someone has not a dead hair cell, but only a damaged one, which on the audiogram is displayed approximately as a drop in the perception of 30 dB.
Can this regeneration technology help in such cases? Meaning to restore the damaged cell, and not to grow a completely new one.
Trials company website: https://www.worldwide.com/
Reviews if you want to dwell on the daily menu issues:
https://www.google.com/maps/place/W...db3a2a!8m2!3d29.5170728!4d-98.4170523!9m1!1b1
People get rejected for trials, this might promote some negative feedback as well.
This treatment is meant to be administered gradually depending on severity of patient condition.
You don't know what exact type of damage is there. They observed regeneration reassembling healthy tissue:
Treatment may create aberrations. I highly doubt it will be a risk free procedure.
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