Frequency Therapeutics — Hearing Loss Regeneration
- Thread starter RB2014
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As positive as this might be, and I am really hoping it is successful, there could be downsides. What if when the hair cells grow back tinnitus gets 10 x louder? What if some people get tumors? What if...?
Caution must be exercised despite our need for a solution. I would wait for a completed phase 3. As I understand it, phase 1 is a very small sample of people who get a really small dose to see if it has negative effects. If phase one doesn't kill or maim anyone, they go to phase 2. Phase 2 is also only testing for negative effects using a larger test group. If phase 2 also doesn't kill or maim, then they go on to phase 3. Phase 3 is the only phase that tests to see if the drug actually works. So skipping phase 3 may not be in our best interests.
I am not as knowledgeable about this stuff as others here, but this was what I read some time ago about a different drug trial I was following.
Caution must be exercised despite our need for a solution. I would wait for a completed phase 3. As I understand it, phase 1 is a very small sample of people who get a really small dose to see if it has negative effects. If phase one doesn't kill or maim anyone, they go to phase 2. Phase 2 is also only testing for negative effects using a larger test group. If phase 2 also doesn't kill or maim, then they go on to phase 3. Phase 3 is the only phase that tests to see if the drug actually works. So skipping phase 3 may not be in our best interests.
I am not as knowledgeable about this stuff as others here, but this was what I read some time ago about a different drug trial I was following.
I believe it was noted in phase 1 that they already experienced positive results in hearing regeneration.
Also, let's just be real here, multi millions of dollars just jumped on board here recently, so I think they feel very strongly about their chances here.
ajc
Member
- Feb 6, 2018
- 1,170
- Tinnitus Since
- 11/2002; spike 2009; worse 2017-18
- Cause of Tinnitus
- Loud music - noise damage
Raising lots of money and having an ostensibly successful drug in the works is NOT guaranteed to be a success.
AbbVie-Backed Startup Raises $133 Million To Fight Alzheimer's With Immunotherapy
A year later...
AbbVie Discontinued a Drug Trial. Biogen Stock Is Falling.
This could happen to Frequency Therapeutics.
AbbVie-Backed Startup Raises $133 Million To Fight Alzheimer's With Immunotherapy
A year later...
AbbVie Discontinued a Drug Trial. Biogen Stock Is Falling.
This could happen to Frequency Therapeutics.
Yes, but, the articles you provide talk about Alzheimer's research and drugs to cure that, as well as other brain diseases. Then the trial they discontinued was for a separate and rare brain disease they were also hoping to cure.
Similarly, Frequency Therapeutics is targeting mechanisms that could help aid a wide array of diseases, but the main focus is currently tinnitus.
Everything is speculation at this point.
What speaks to me is that they ran the first trial, and all the sudden a lot of additional money came out of the woodwork. I think investors had access to phase 1 results and now they really want to join.
Apparently we'll be let in on the results in a month or two.
Just for clarification, the main thing they are trying to treat is hearing loss, not tinnitus.
The hope for us is that tinnitus will be treated as a result of treating hearing loss, but that is not their main objective.
It is true that a lot of money and new partners coming in doesn't guarantee that it will work, but it sure is a great sign that it probably will.
Now if it cures our tinnitus is another story, we just don't know for sure. I really hope it will, but no one knows for certain. Logic says it should help, as most of the science community agrees. But what is almost certain, if it does work, it'll help those that are currently ineligible for treatments like Lenire become eligible by having their hearing restored.
Even if it does not cure the tinnitus, at least I will have better hearing! Which will do wonders in masking my tinnitus.
And like @ChrisBoyMonkey said, those of us who aren't eligible to use Lenire because of hearing loss will be able to get the treatment in the future. I pray this drug is successful and that it comes out quickly.
And like @ChrisBoyMonkey said, those of us who aren't eligible to use Lenire because of hearing loss will be able to get the treatment in the future. I pray this drug is successful and that it comes out quickly.
For the inquiring mind:
https://patents.google.com/patent/W...Lean&q=hair&q=cells&oq=Will+McLean+hair+cells
https://patents.google.com/patent/W...Lean&q=hair&q=cells&oq=Will+McLean+hair+cells
https://www.sciencedaily.com/releases/2019/07/190731125448.htm
The key to this article being other neurological disorders.
The key to this article being other neurological disorders.
What makes you think there is a chance nerve synapses would be damaged as well?
Are damaged nerve synapses a potential cause of hyperacusis?
The reality is we don't know when there becomes too little supporting cells for this to work. But they suggest moderate hearing loss is the limit to FX-322's effective. Noise damages so many different things in the cochlea not just hair cells.
Oh, that's perfect. I have progressive hereditary hearing loss so by the time this comes out I probably won't have enough hearing for Frequency Therapeutics, either. Looks like both my tinnitus and hearing loss are here to stay
. Nothing quite like having a whole bunch of new treatments for tinnitus for the first time ever, only to not be eligible for literally any of them. Staying optimistic is getting harder and harder...
I believe @Aaron123 posted the source along time ago about "moderate hearing loss being the therapeutic limit". It is somewhere in this thread multiple times.
I'll look for it.
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