Yes, synapses and nerves are more fragile then hair cells. That's the controversy. Hair cell regeneration might not help everyone because synapto-neuropathy plays a larger role in SHNL then scientist previously thought. Facts don't care about feelings, if nerve damage outweighs hair cell death the treatment will be ineffective. Someone correct me if I am wrong.
I've only found eveidence of the opposite. Their first trial was done only with people who had no more than a pure tone average of 70 dB (severe hearing loss).
I don't think Frequency Therapeutics have put a definite limit on whom FX-322 may or may not be able to help. Stay optimistic.
Pretty sure they only tested it in those people because they were already receiving a cochlear implant so their ears were effectively already fucked and there was no real risk of causing further loss.
This is what I saw too. I believe the people in the trial were already scheduled for cochlear implants.
Of course that too, but the cochlear implant candidate appears to be their target consumer.
Pretty sure you're right.
They're talking themselves up to investors, comparing themselves in the best light against the 'competition'. Of course they'll sell to sell to that market, assuming it works for people with that degree of hearing loss. It doesn't make it their target market. It's probably not big enough to justify the billions they seem to be expecting to make, and many people in that group probably will have more going on than just sudden sensorineural hearing loss. Last but not least, none of participants in the San Antonio trial were cochlear candidates as far as I know. So no, not their target market.
Well, this is disconcerting.
Have you ever thought hyperacusis defined as "Pain from sound is not the same thing as "noises sounding abnormally loud?
That's a pretty big "if". Some hypothetical treatment which would restore 30% of your lost hearing could be life-changing for someone with 50 dB loss thresholds, but more or less meaningless to someone with tinnitus despite ~10 dB loss thresholds.
I'm grateful for the existence of Frequency Therapeutics and all others out there researching into hearing loss, tinnitus, and hyperacusis. It is a shame, however, these conditions appear to be so far behind in research. Perhaps I'm naive though. I myself am going in circles with all of this. One minute it is a hair cell problem, next the nerves. One minute it's because of stress, the next because of noise. Maybe one day we'll have definitive answers.
Why aren't heroes of basic logic like you involved in tinnitus research? Instead we have fashionistas like Derek Hoare stealing tax dollars to play games.
My mistake, as I already corrected. "Hearing loss". Being that it's a widely accepted theory that NIHL-based tinnitus is the brain making up for lack of sensory input from the nerves/hairs etc, it is very reasonable to speculate that curing or majorly improving hearing loss will then give new sensory input to the brain, allowing it to stop the tinnitus.
I hope that is the case but there are definitely changes to the underlying nerves involved in tinnitus. Whether or not these changes are a result of hearing loss and will be corrected by restoring hearing or not is something that I want the answers to.
Perforations on an inner ear bone structure?
First off, the specialists in the tinnitus field are people like Pawel Jastreboff, so who cares what they think in the first place?
It will likely begin phase 2 very soon, probably within the next few months before the end of the year. They have just gotten a bunch of investors, mainly one really big pharmaceutical company, to pour in money and help them conduct trials worldwide along with a deal to sell the treatment once it is commercialized.
I don't think so. I'm pretty sure now his condition was otosclerosis.
Doctors who preform CI surgeries have first hand knowledge of the ear. So I wouldn't immediately discount their information, especially if it relates to the structure of inner ear.
OK thanks. I know a thing or two about otosclerosis since I have it myself and gone through the surgery.
When you expose yourself to loud sounds, your supporting cells generate a lot of glutamate, which in large quantities causes glutamate excitotoxicity in your auditory nerve synapse. This is called the "glutamate storm". That could be the root of many of our tinnitus cases. This would explain tinnitus in people like you and I that have very little measurable hearing loss.Hello,
Last week, I went for a hearing test that went up to 12500 Hz, and the results showed that my audiogram was perfectly normal (just a "loss" of -10 dB at 12500 Hz).
My question is, as my tinnitus appeared the day after a concert, so because of an acoustic trauma, and that in December 2018, I still had hearing losses in the low range from -20 dB to -25 dB, but that I technically "recovered" all my hearing; I wonder if I still have hidden hearing loss, and if by regenerating it, my tinnitus could disappear or decrease? Or if hidden hearing loss is different from "visible" hearing loss with regard to the principle of hearing regeneration?
I would like an answer to these questions.
Simple speculation
Thank you for your answer !
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