Frequency Therapeutics — Hearing Loss Regeneration

[Rb86]

Just look at drugs like Accutane or Finasteride. They are made to treat minor problems such as moderate acne or baldness and have potential permanent side effects. Finasteride destroyed my "hormonal system". How can it be approved to treat such a mild problem? And there are thousands of stories on the Internet. Look at the amount of people here who got their tinnitus from taking a pill like Clonazepam. They are clearly not well tested or the system is corrupt.

I had pretty heavy acne in highschool, enough that I have some scars today. Anyway, I took accutane as did my sister. The chapped lips were a pain at the time but it also majorly cleared up the acne.

 

[Earing]

They used this time to land a big pharma whale investor.

 

[Rafalek73]

Yes my tinnitus is very reactive and when I use my hearing aids the tinnitus seems to be trying to be on the top of any sound. Very weird, it is hard to even explain it. I have high frequency hearing loss, it starts at 4 kHz all the way to 8 kHz. The biggest gap is at 8 kHz - 70 dB hearing loss. One will assume that I can benefit from hearing aids but unfortunately that is not the case.

Identical to me.

 

[Mr Mister]

I'm coming to this thread every ~6 months and I'm amazed when I see posts here nearly everyday whereas Frequency Therapeutics may only publish some info twice a year.

It is not only about Frequency Therapeutics and their publications. Discussing tinnitus and hearing loss is very therapeutic and it is a comforting feeling that you are not alone. I am grateful we have sites like this as nobody close to me has a clue about life with tinnitus and hearing loss.

 

[RB2014]

Look at the amount of people here who got their tinnitus from taking a pill like Clonazepam. They are clearly not well tested or the system is corrupt.

If they needed clonazepam then they were already on their way to getting tinnitus. Just my opinion.

 

[jeff W]

Just to be clear, there are people--including on this forum--who have tinnitus without hearing loss.

Just to be clear, there are types of hearing loss and hearing damage that cannot yet be measured objectively, just because it doesn't show up on a pure tone, that doesn't mean it is not there, current hearing exams are quite limited, some would call them rudimentary. Hopefully audiology can yield some progress after these trial results are released. But new testing techniques will eventually arrive.

 

[Time4fix]

When you expose yourself to loud sounds, your supporting cells generate a lot of glutamate, which in large quantities causes glutamate excitotoxicity in your auditory nerve synapse. This is called the "glutamate storm". That could be the root of many of our tinnitus cases. This would explain tinnitus in people like you and I that have very little measurable hearing loss.

If this is the case and our hair cells aren't dead, then I fail to see how FX-322 will help. There are other things like OTO-313 and OTO-413 that would be more likely to help.

Forgive me for my ignorance but I just want to understand this better.

Say hypothetically someone only has hidden hearing loss (synapse disconnected from hair cell), and all of the hair cells would be fine so FX-322 would not do anything. Could inflicting damage to hair cells on purpose then give room for FX-322 to work, and so forming new hair cells that are connected to 'new' nerves/synapses? In some way shifting the problem.

Again, forgive me for my ignorance. I'm just trying to learn and give this thought.

 

[JohnAdams]

If anyone here knows electronics back me up on this.

When you have an op-amp, it needs a good reference level, which is usually ground or virtual ground, this is a steady voltage, which is why it's called reference. If you have no ground or a ground fault, it introduces all kinds of imbalance to the circuit, this can manifest as "noise" in the circuit.

Our nerves are electrochemical, sodium and potassium channels along the axon. There is a RESTING voltage potential of around -70millivolts, thats -0.70 volts. That's silence in your auditory nerve.
An impulse goes to about +30 millivolts which is a difference of 100 millivolts or .1 volt. 1/15th a AA battery.

View attachment 24292
http://www.biologymad.com/nervoussystem/nerveimpulses.htm

I've taken 110 volts to the hand which is 1,100 times more and it never caused a sensory input dysfunction, but chop my hand off and I'll get phantom limb sensations.

Doesnt this mean that the phantom auditory sensation aka tinnitus is from loss of sensory input? Perhaps a lack of the resting voltage potential from intact nerves?

Take analog TVs for example, no plug, static, video, static hiss audio. Not black silence. Plug in a source with no content, black and silence. I think this is tinnitus.

RIP this theory to shreds if you can please.

Forgive me for my ignorance but I just want to understand this better.

Say hypothetically someone only has hidden hearing loss (synapse disconnected from hair cell), and all of the hair cells would be fine so FX-322 would not do anything. Could inflicting damage to hair cells on purpose then give room for FX-322 to work, and so forming new hair cells that are connected to 'new' nerves/synapses? In some way shifting the problem.

Again, forgive me for my ignorance. I'm just trying to learn and give this thought.

That's been hypothesized here before but I don't think that is a good idea at all.

 

[Time4fix]

That's been hypothesized here before but I don't think that is a good idea at all.

Right I see. So it's waiting for Grequency Therapeutics, Otonomy or Decibel Therapeutics right now? I haven't found that much info about Otonomy or Decibel Therapeutics and their future plans/steps.

I hope we know a whole lot more about Frequency Therapeutics when they do their talk on the 17th of September.

 

[Gorbeh3]

https://finance.yahoo.com/news/frequency-therapeutics-expands-leadership-team-123000568.html

Two more very intelligent people joining the Frequency Therapeutics team.

As a man with confirmation bias, I am interpreting this as excellent news.

 

[Lucifer]

Right I see. So it's waiting for Grequency Therapeutics, Otonomy or Decibel Therapeutics right now? I haven't found that much info about Otonomy or Decibel Therapeutics and their future plans/steps.

I hope we know a whole lot more about Frequency Therapeutics when they do their talk on the 17th of September.

Also Audion Therapeutics/REGAIN is another company as well. They are currently in Phase 2 at the moment and should have results posted by 30/04/2020. Not too sure if after they are done with Phase 2 whether they move to Phase 3 or have a Phase 2b etc.

 

[JohnAdams]

Also Audion Therapeutics/REGAIN is another company as well. They are currently in Phase 2 at the moment and should have results posted by 30/04/2020. Not too sure if after they are done with Phase 2 whether they move to Phase 3 or have a Phase 2b etc.

Dude, there are only 12 months. What calendar are you using bro?

 

[Lucifer]

Dude, there are only 12 months. What calendar are you using bro?

I use the Day Month and Year format which is used in my country.

 

[JohnK]

I use the Day Month and Year format which is used in my country.

Yeah that's pretty much every country except for America haha.

 

[ChrisBoyMonkey]

Right I see. So it's waiting for Grequency Therapeutics, Otonomy or Decibel Therapeutics right now? I haven't found that much info about Otonomy or Decibel Therapeutics and their future plans/steps.

I hope we know a whole lot more about Frequency Therapeutics when they do their talk on the 17th of September.

Auris Medical is another one but that one is a solid maybe. We're not sure if their tinnitus drug works, the last trial wasn't a success but they don't think it was because of the drug not working.

 

[JohnAdams]

I use the Day Month and Year format which is used in my country.

MONTH/DAY/YEAR INCH FOOT MILE GALLON

 

[Daniel Lion]

Just checked the Frequency Therapeutics website as you do.

They hired some more super qualified people.
I didn't provide a link... sorry.

A little news until mid September.

It looks like they are gearing up for the next trial phase and to expand their therapies to MS and beyond.

Fingers crossed that these cats will deliver the goods.

 

[Fabrikat]

https://finance.yahoo.com/news/frequency-therapeutics-expands-leadership-team-123000568.html

Two more very intelligent people joining the Frequency Therapeutics team.

As a man with confirmation bias, I am interpreting this as excellent news.

They're preparing to initiate Phase 2a trials. Sigh! Does that infer a prospective 2b after that?
It's all soooo slow!

 

[Pero1234]

You have to admit, Americans are pragmatic.

Now where did I leave my measuring tape? Oh, wth... let's try this... there! This thing is 7 foot and 3 inches long! Try measuring it for yourself, see?

Cool huh, who needs those metric measuring gizmo's anyway :-D

Glad we left that whole video PAL vs NTSC thing behind us

 

[acute]

If they needed clonazepam then they were already on their way to getting tinnitus. Just my opinion.

What do you mean?

 

[Time4fix]

Am I wrong to think that when I look around this forum, comparing the beginning and now, research, information and the possibility for clinical remedies has improved quite a lot?

 

[Lucifer]

Am I wrong to think that when I look around this forum, comparing the beginning and now, research, information and the possibility for clinical remedies has improved quite a lot?

Definitely. I remember when I first joined Tinnitus Talk I only knew about Auris Medical but that turned out to be unsuccessful. Now with Regain and Frequency Therapeutics being in Phase 2 and hearing that people who took the drug had improvements in tinnitus, hyperacusis and hearing loss actually gives me hope, and this drug cannot fail since people had improvements.

 

[JohnAdams]

Am I wrong to think that when I look around this forum, comparing the beginning and now, research, information and the possibility for clinical remedies has improved quite a lot?

We still don't know if restoring hearing in any of these trials improved tinnitus symptoms.

What's maddening is that I think they know at this point and it would be great if they would just say, "hey even though we saw hearing threshold improvements, the patients did (or did not) report improvements in their tinnitus, if they had it."

 

[JohnAdams]

Yeah that's pretty much every country except for America haha.

At least we aren't in the stinky EU!

 

[Time4fix]

We still don't know if restoring hearing in any of these trials improved tinnitus symptoms.

What's maddening is that I think they know at this point and it would be great if they would just say, "hey even though we saw hearing threshold improvements, the patients did (or did not) report improvements in their tinnitus, if they had it."

I truly hope that we'll know that soon.

 

[GregCA]

Glad we left that whole video PAL vs NTSC thing behind us

Never Twice the Same Color!

 

[Time4fix]

Sometimes I seriously wonder if anything will come from a direction that we don't expect like China. Wish I could do some research about what they have/have coming.

 

[JohnK]

I have fears I'll find FX-322 only works in cases of low frequency hearing loss and not high frequency hearing loss like I have.

But then again they mentioned improved "word scores" in some subjects which implies high frequency improvements...

I also have fears FX-322 will only work on acoustic trauma and not ototoxic destruction (hopefully neomycin doesn't take out the progenitor cells... I'd hope not because some study used aminoglycosides to kill hair cells in birds and they still regenerated their hearing back... ahh I love over extrapolating from the scant research we have).

 

[FGG]

I have fears I'll find FX-322 only works in cases of low frequency hearing loss and not high frequency hearing loss like I have.

But then again they mentioned improved "word scores" in some subjects which implies high frequency improvements...

I also have fears FX-322 will only work on acoustic trauma and not ototoxic destruction (hopefully neomycin doesn't take out the progenitor cells... I'd hope not because some study used aminoglycosides to kill hair cells in birds and they still regenerated their hearing back... ahh I love over extrapolating from the scant research we have).

If anything, it would likely work better on high frequency loss because the drug has a shorter distance to diffuse from the round window.

 

[ChrisBoyMonkey]

Sometimes I seriously wonder if anything will come from a direction that we don't expect like China. Wish I could do some research about what they have/have coming.

They're working on some things too, they just don't seem as promising as bimodal neuromodulation at this time. I posted one of the trials they are working on, I think it was electro acupuncture.