Does anyone think reactivity is caused by damaged synapses? Looking to understand this further. My reactivity competes with all sounds but goes back down when the sound is eliminated. No actual hearing loss here besides "hidden hearing loss" at 16 kHz and up but I'm 36.
It's going to be impossible for anyone on this forum, or any doctor to reliably diagnose the underlying causes of tinnitus. There aren't tests that can objectively measure what you're experiencing, and everyone's experience is different in the acute phase and chronic phases of this condition.
Thanks @Diesel. This is helpful. It's the reactivity aspect that is the most torturous for me and, like others, I wish I had a way to address that alone. I do have 2 OAEs (although conflicting) that point to some losses and I am experiencing sound sensitivity aka hyperacusis (no pain though). I do think the sound sensitivity and reactivity go hand in hand so thanks for the info again.
It is one hypothesis we are trying to validate. It takes a very long time, though.
Isn't this what FX-322/345 is intended to do? It's not gene therapy, but activating cells and replacing damaged hair cells. Am I missing something?
Yea and your brain can usually adapt to hearing loss, but if the loss is too big or the brain is hampered by stress or little sleep, it will fail to adapt.
It is a molecular solution intended to activate the cells themselves to replace the damaged hair cells. Gene therapy manipulates human genes to express desired genes and suppress those that are undesirable. For instance birds have genes that make it a norm that their hair cells regenerate automatically. Whereas humans and most mammals have not kept this ability. If such a gene is latent in the human genome, then gene therapy is aimed at activating said gene and not solely the cells themselves.
Interesting. Looks like the 300k volume @ circa $4.30 on 2/17 was him. Price currently @ $3.46.
Dude let me know when you decide to get some shares. I'm waiting for it to bottom out too. Probably around $3.00? Too early to tell but imagine getting it at $2.00 and going back up to $50-60. Sheesh.
Today's open is going to be telling. If it's above $3.50, (circa $3.55 would be nice on a gap up) then that would be quite an important first development for the long term. If it opens below $3.48 I'm going back to sleep lol.
You can worry about a lot of things but no point comparing 8 bangers with inner ear hair cells. Probably everyone got some hair cells malfunctioning inside here and there. If they fix most of them, the rest our body will take care of.
No gap up and the opening H1 candle just closed lower @ $3.38. Not really that interested in FREQ right now.
What are you thinking for long term? Results come out in November? If this drug gets passed, either way it's going to the moon.
Hey man,
Thanks for the info! Yeah, it is definitely very bearish. I don't see it going back up any time soon. I won't go crazy, if it hits $2 I'll buy a few shares and just hold. As of now it seems way too volatile and only dropping, and yeah of course we are all biased! When it comes to investments, biotech is high risk, high reward as you already know. Lmk if you think it bottoms out. I won't buy any for a while. If I see a good support, then maybe.
I am also patiently waiting for FREQ to hit bottom so I can make a larger purchase. It's a tricky game, that's for sure.
It really is. What are you waiting for? I was thinking $2.00 or $2.50. I try not to let my biased opinion get the best of me because the market doesn't care. But it really seems like this drug works and that too many injections and desperate people lying to get in ruined the trials. Getting this stick with Otonomy at such a low price would be so much return.
It's impossible to time the market, you will only know it's the bottom until after it passes so it's best to just cost average in. Granted, I'm deeply in the red on FREQ as I started accumulating shares around $8 so I was clearly too early. I remind myself of the quote from Christian Bale when he plays Michael Burry in The Big Short "Just because I'm early, doesn't mean I'm wrong." as Burry was deeply in the red leading up to the housing market collapse when he bet against housing, but he finally made out like a bandit when it did collapse.
The thing is though we're not repairing them or "fixing" most of them, we're bypassing them or creating new hair cells beside the damaged old hair cells whilst the damaged areas are still connected to the brain.
Ouch man, but yeah keep holding out! Nice article with good info. Yeah I mean this is definitely a big market with no competition besides Otonomy so far. Either one getting approved would be huge and lots of profit. But yeah everything aside I try to be realistic, there's definitely no guarantee this or Otonomy will pass but there is a good chance. $2.00-$3.00 a share is a good buy in for FREQ. For Otonomy I'm waiting for one more dip below $2.00 and I'm all in.
Many hearing aid users report a decrease of their tinnitus when their hearing aids are in. That fact along with the theory of residual inhibition strongly suggest that a restoration of signal reduces tinnitus.
I get residual inhibition. My tinnitus screams when I wake up and then actually quietens and disappears when sound is introduced and then reappears in silence.
The most I can offer as an explanation to your concern is that the replacement and or transdifferation these hair cells would go through will replace the damaged connection as they are all part of the same system. Mind you this is all very unproven for humans and most mammals. However, in birds it has been shown to fully repair and replace damaged hair cells in the cochlea.
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