This is a pretty good example of result/progress I think:
Well I suppose that if the body detects that there is something new, it connects it.
That's what's interesting about FX-322 / Progenitor Cell Activation. In vitro, Frequency has observed the output of PCA where a new daughter cell (hair cell) is create with a nerve. While it cannot be observed in vivo in the cochlea, they have observed a signal via improvements in word recognition tests. Therefore, the conclusion thus far has been that the regrown hair cells are establishing a signal with the brain, resulting in improved word scores.
Chad, are you seeing FREQ starting to move a little? Almost at two bucks now. Let's hope it keeps going...
Yea, hopefully it will slowly keep climbing as we get closer to phase 2 results. The fall all the way to $1 wasn't quite organic because a couple of the large institutions unloaded their positions the last couple months and that drove it down quite a bit.
That's a little odd to me. At least looking at their website, DBTX looks way less along than FREQ. The Pipeline section says that they've yet to reach Phase 2 on a single one of their products. It seems super risky to gamble on just Phase 1 results. All that proves is that it isn't going to kill a human, it can essentially be sugar water otherwise.
Does anyone know if there is an age limit for the potential efficacy of these treatments? I'll be 60 this year, and I keep being told that hearing loss (and tinnitus) is age-related. By the time this product actually is available, commercially, I could be pushing 65.
Check out the inclusion/exclusion criteria:
It's not well understood. You can't quite point to the exclusion criteria in the trial to know for sure; that criteria is to ensure the trial participants are reliable in placebo effect / drug response.
Phase 1 is a safety trial but that doesn't stop them from conducting efficacy tests at the same time and they showed some pretty promising results with 87% of subjects showing some level of hearing protection from the ototoxic drugs.
Age won't be a factor in restoring hearing. Lots of seniors have good hearing so clearly loss in hearing has many other factors than age, including noise over the years and medications.
What's coming in medicine are things we can't conceive of. We're not experts in the field. I wonder if there'll be a CRISPR program for hearing loss. You get tinnitus or hearing loss. They take your DNA, run the program, and then you'll come back for the mRNA edit and you're closer to "normal" than the onset. Or maybe this can just turn off the noises everyone hears.
Hopefully some positive info has leaked. The stock is up 135% in the last two months.
This lines up with FREQ's age-related hearing loss trial, they did not see a robust response in that trial which also suggests age-related hearing loss is not caused by sensory hair cells.
It would be prudent to see some 13-F filings to find out if it's retail driven or institutional driven. Not sure where or when to find them. Can anyone help us out?
Does anyone know yet why subject 5 got a lot worse from baseline after the shot?
You can damage your hearing by noise exposure pretty easily afterwards, so just because you regain something, that doesn't mean you can't damage it again.
That's interesting. Anything foreign to the body is normally attacked, be it pathogen, chemical or whatnot. We see this in transplant patients due to the part being very minimally different at cellular level.
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