While that's true, the reason these new hair cells may be attacked is because this protein is specifically an anti-tumor oriented reaction to prevent the cells dividing and turning cancerous. It's this relationship that makes notch therapy ideal for cancer research. As the inactive nature of the gene(s) responsible for preventing cancerous cell division is what leads to tumors and cancer in the body.
I am hopeful but I try to be overly cautious. As I worry it may be too good to be true at times.
They will work. In the beginning there won't be a permanent one-time solution, but as years go by, treatments will become more and more effective, as with everything.
People maintained hearing benefit a year after the FX-322 shot. I hope it can be permanent.
I'm very interested if the potential for multiple doses is there as well. It seems like the scientists at Frequency Therapeutics sure thought so, but making the dosing schedule so compact was obviously a big mistake. We'll have to wait and see, but I'm sure at some point in the future after the single dose is more solidified and proven, they'll go back to the drawing board on the multi-dose route. Here's to hoping they crack this thing.
Based on what I get from Frequency Therapeutics' comments, scheduling is what they are also trying to figure out for future trials. Carl LeBel mentioned that they have identified what seems to be people having "their own unique timeframe" to respond.
Usable voice frequency band is 300 Hz - 3400 Hz. If word recognition is improved, then I would imagine tinnitus may benefit from these spectrums. Can't see how 10,000 Hz would benefit other than it being exposed to the medication first. Most of speech energy is produced in the low-mid range of human hearing. This is all speculation of course; there might not be any benefit.
Lots of research in recent years is pointing to the ultra high frequencies helping with speech perception, especially in noise.
ClinicalTrials.gov: FX-322 in Adults With Acquired Sensorineural Hearing Loss
It's way higher than 3400 Hz. Take a look at the speech banana:
The trial ends in November. There will most likely be a quiet period to clean up the raw data and compile it into a report.
I thought a previous trial established no audiometric improvement of EHFs. I know we've seen some differences around 8 kHz, but I thought there was still some skepticism over what this actually was. Has there been an update?
I can literally hear everything on that chart. Birds chirping, leaves rustling, tap running. So this medicine may not help me but it can still help others.
You don't understand how hearing works. I am producer and hearing doesn't only improve by threshold, it's much more complicated and deep what hearing means, and that is why I trust them entirely. Just because something can't be seen on paper, doesn't mean it doesn't improve a person's life tremendously.
@Geatly, but they had no better results than OTO-413. As we saw in Phase 1 of OTO-313, such a small group often doesn't translate to larger groups. A small group gives a much higher 'chance' result that looks meaningful but isn't.
A pure tone average at the Screening Visit of 35-85 dB at 500 Hz, 1000 Hz, 2000 Hz, and 4000 Hz in the ear to be injected.
While it may seem barely significant to you, I can guarantee you it is life changing for the subjects who were statistically significant. Subject 4 for example went from being a clear candidate for a hearing aid to being able to possibly get by without one.
FX-322 is hitting 8000-20000 Hz. Don't expect a lot from that on audiograms and various tests, since those frequencies are not as important to hearing as those below 8000 Hz.
But did we ever get evidence that extended high frequency thresholds actually improved via an EHF audiogram? Or is this just affecting synapses in that range and not actually thresholds? My understanding might be a bit off here.
The implication has been that inner hair cells are regenerating, but possibly not (or not enough) outer hair cells. This would explain the word score improvement and WIN improvements, but not audiogram improvements.
From what I understood of the animal models, it was inner hair cells.
I wouldn't sink them just yet. They've made corrections to their tests so the possibility still exists for success.
Brother, if you have a more positive outlook on the future, then you will have a better future.
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