Has Anyone Here Tried a Melatonin and Klonopin Combination Right Before Going to Sleep for Tinnitus?

[JasonP]

I read this article where chronic melatonin dosages each day enhanced the binding on the benzodiazepine site on the GABA receptor. The article is here: https://www.ncbi.nlm.nih.gov/pubmed/3668517

As some of you know, benzodiazepines can help lower tinnitus for some time but usually eventually stop working. With some people, they might even get tinnitus from chronic benzo usages or abrupt withdrawals from taking the medication.

It seems to me that if this works for some people that the melatonin would have to be taken either the same time the klonopin was swallowed or shortly before. (If the melatonin was sublingual I think the klonopin could be swallowed at the same time.) To me it seems the important thing is that the melatonin is in the system before and/or during the klonopin binding to the site. It is also my theory that if this works it would be ideal that the benzodiazepine and melatonin would be taken right before going to bed at the normal bedtime for the person because of the body clock and natural melatonin production.

If this works what concerns me is how long it would work for. I do not know nor do I know the melatonin dosage although it must be a safe dosage.

I'm going to post this video which may explain things on a very basic level on the benzodiazepine binding site on the GABA receptor:


I think I am going to do an experiment with it tonight and see what happens.

 

[Luman]

Looking forward to the results of your experiment. Thanks, and good luck.

 

[JasonP]

Looking forward to the results of your experiment. Thanks, and good luck.

Thanks so much. I can do that. One thing I forgot to do was state that the experiment was done on rats. Maybe it will work on humans...the scary part though, if it does, how long will it last and be repeatable for?

 

[Scared111]

I read this article where chronic melatonin dosages each day enhanced the binding on the benzodiazepine site on the GABA receptor. The article is here: https://www.ncbi.nlm.nih.gov/pubmed/3668517

As some of you know, benzodiazepines can help lower tinnitus for some time but usually eventually stop working. With some people, they might even get tinnitus from chronic benzo usages or abrupt withdrawals from taking the medication.

It seems to me that if this works for some people that the melatonin would have to be taken either the same time the klonopin was swallowed or shortly before. (If the melatonin was sublingual I think the klonopin could be swallowed at the same time.) To me it seems the important thing is that the melatonin is in the system before and/or during the klonopin binding to the site. It is also my theory that if this works it would be ideal that the benzodiazepine and melatonin would be taken right before going to bed at the normal bedtime for the person because of the body clock and natural melatonin production.

If this works what concerns me is how long it would work for. I do not know nor do I know the melatonin dosage although it must be a safe dosage.

I'm going to post this video which may explain things on a very basic level on the benzodiazepine binding site on the GABA receptor:


I think I am going to do an experiment with it tonight and see what happens.

i have tried this a few times. no difference for me.

 

[JasonP]

i have tried this a few times. no difference for me.

Okay, here is what happened: I had very loud tonal tinnitus yesterday. It was debilitating for me when combined with my depression issues. I took 3mg melatonin around 2:30 a.m along with .5mg klonopin. The way I took it is by swallowing .375mg klonopin right after sublingual melatonin and then after that disolving .125mg of klonopin in my mouth. I don't like doing that but I was so scared about waking up with loud tinnitus again. I don't recommend it long term. I was able to get to sleep probably between 30 minutes to an hour later. I hope I am not making things worse for myself after taking such a larger dose of klonopin than I was used to.

Notice: I had been going to bed at 5 a.m. for the past few nights because of various reasons. If I wanted to, I could go to bed without the aid of klonopin but my natural body clock had shifted to that time.

The normal amount of klonopin I had been taking was ranging in between .125mg and .25mg a day, but it wasn't all after my klonopin...I think the night before my tinnitus was extremely loud tonal I took probably less than .0625 after 1.5mg melatonin.

When I woke up the loud tonal tinnitus was not there but mostly a white static like type of tinnitus along with a whistle (which is what I had before taking klonopin.) I then took 100mg Lamictal (of course I titrated up to that amount a long time ago) and most of the static type tinnitus went away after 1 hour. My tinnitus is significantly lower than yesterday as of the moment. I may write a separate post on this and my theories about what is going on. What scares me is that I would like to take the lowest amount of klonopin possible and wonder if the melatonin/klonopin combo will stop working.

 

[Luman]

Thanks so much. I can do that. One thing I forgot to do was state that the experiment was done on rats. Maybe it will work on humans...the scary part though, if it does, how long will it last and be repeatable for?

I'm only a newbie, 10 weeks or so with T. I take 1 mg of melatonin sublingual before sleeping, I used it even before T. I have not woken up without T since this began, but I have had some relief late nights, and when taking clonazepam (Klonopin), which I am using very sparingly two or three times a week. I find that if I fall asleep on clonazepam, even for a few minutes on the subway, the T returns. I am hesitant to mix clonazepam and melatonin at bedtime, I'm afraid I'll be too groggy and fall or something if I get up at night. Just be careful if you try it, and good luck.

 

[JasonP]

I'm only a newbie, 10 weeks or so with T. I take 1 mg of melatonin sublingual before sleeping, I used it even before T. I have not woken up without T since this began, but I have had some relief late nights, and when taking clonazepam, which I am using very sparingly.

I find that if I fall asleep on clonazepam, even for a few minutes on the subway, the T returns. I don't want to mix clonazepam and melatonin at bedtime, I'm afraid I'll be too groggy and fall or something if I get up at night. Just be careful if you try it, and good luck.

Yes, I think klonopin alone and then a nap can make things terrible for me.

 

[MBH]

I have been trying to stay with natural products, I've been giving different meds from different doc and also had bad experience with two past ones, due to I'm trying to deal with anxiety symptoms,but what I realized is I was really thinking if I take these meds my T would go away or stay the same, but I now realize T has mind of its own. So since I am only in this 3months and trying to take care of anxiety which I did not have before, anyway at night I take a long shower, deep breath, 2 melatonin, 2 tyelynol pm, fan, and sound machine that plays different sounds, I sleep 7 hours. During the day I take st John's wort and magenism and qinkgo Biloba. It is hard to except T. All these meds makes it very confusing since most docs don't take control and you end up going to many of them.

 

[Sointu]

I have used benzos and Melatonin combination for years, even before the onset of my tinnitus.

I first used a bigger dose of benzos and Melatonin but tapered them to a lower dose because I felt a bit groggy in the morning when using a bigger dose of benzos and Melatonin in the past. I have only used 0.5 mg of Melatonin and microtapered my benzo dose to a really tiny amount. Before tinnitus I was sleeping okay, without waking up at all during the night; in some cases sleeping 7-8 hours a night. I was thinking completely tapering the benzos off.

My tinnitus and hyperacusis started after acoustic trauma while tapering the benzos.

I have had one experience of loudness hyperacusis in the past. Probably caused by benzo tolerance or rapid taper. Or antidepressant taper. Something made me really sensitive to sound. The symptoms resolved after I reinstated benzos and tapered slower. I was living a completely normal life before the acoustic trauma. No symptoms of hyperacusis. Only thing I did differently was using earplugs at night because during the benzo taper I woke up easier than normally to normal sounds at night such as my dog moving around.

After my tinnitus started I had some insomnia but it has been getting a bit easier. I still use the combination of Melatonin and benzos. I get more night time awakenings though.

I would not recommend using benzos for sleep but when I was prescribed them I had bad insomnia.

 

[GoatSheep]

So I took Clonazepam by itself for over a year when I first got tinnitus as it helped reduce my tinnitus volume and helped me sleep. Tapered with no problems really.

Recently had a hyperacusis setback and to try to get my ears to calm down I took 1 mg Clonazepam. I've been taking Melatonin for awhile now since previously discontinuing the clonazepam.

Last night I woke up with horrible heart palpitations and a weird spike. If I put on ear muffs I can tell the tinnitus isn't really significantly louder, but it's a horrible fuzzy mess, not like a calm static tone.

Wondering if the combo of those two could be the culprit.