Injectable Polyplex-Loaded Glycol Chitosan Thermogel for Efficient and Safe Inner Ear Gene Delivery

[Frédéric]

Yet another team is trying to solve the inner ear delivery issue.

Injectable polyplex-loaded glycol chitosan thermogel for efficient and safe inner ear gene delivery

Highlights

• A novel RH-PAMAM G2 polyplex-loaded HGC thermogel system has been designed to enable effective gene delivery to the inner ear.
• RH-PAMAM G2 exhibited excellent gene delivery efficiency into HEI-OC1 cells.
• RH-PAMAM G2 polyplex/HGC thermogel formulation enabled prolonged delivery, targeted gene delivery, resulting in more distribution of anti-GFP in the cochlea tissue.
• This formulation holds strong potential as a promising therapeutic approach for otic gene therapy.