Interview with Decibel Therapeutics' New CEO

[Jim51042]

mass ear and eye is going to do clinical studies on cochlear synapathy

Cool. Do you have more details on this?

 

[Flamingo1]

I disagree, the fact that they are disclosing less information than Frequency does not necessarily mean they are behind.

There's always the incentive to be the first to market. Business 101.

 

[lapidus]

Decibel Therapeutics Announces Investment from GV to Expand Capabilities for Biological Target Identification in Hearing Loss and Tinnitus

http://www.businesswire.com/news/ho...s-Announces-Investment-GV-Expand-Capabilities

 

[sharonr]

Frequency is not into phase 1 this year, should be next year. The trial in Australia is not phase 1 for their product.

Hi, who is holding a trial in Australia and are there any details.
Thank you.

 

[Frédéric]

@sharonr : this link :
https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=372587

 

[RODRIGO]

we'll have to wait one year before results...while more nice news will come.. it seems like a revolution.
we are living things that were almost science ficcion 5 years ago...im sure that this is the first.

 

[Flamingo1]

Hi, who is holding a trial in Australia and are there any details.
Thank you.

Frequency Therapeutics

 

[VRZ78]

we'll have to wait one year before results...while more nice news will come.. it seems like a revolution.
we are living things that were almost science ficcion 5 years ago...im sure that this is the first.

Last data collection is planned for this September. So well probably know in less than a year...

 

[RODRIGO]

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=372587
In the link says that the duration of the study will be 10 months

 

[Wojtek Kalka]

Have a friend working there

 

[Fabrikat]

Frequency have also opened an office in Melbourne. Seperate to the hospital where the testing is being done and to Melbourne University, which is also involved. It's all very interesting.

 

[sharonr]

Thank you all for your replies.
That's great because I live near Melbourne.

 

[sharonr]

I am not even close to the criteria.
I have high frequency hearing loss.
Do you think they will do further trials for people with not so much damage.
Thank you.

 

[Fabrikat]

I am not even close to the criteria.
I have high frequency hearing loss.
Do you think they will do further trials for people with not so much damage.
Thank you.

No one knows what the selection criteria will be for future trials until they announce them. More likely to be conducted in the US however. The Frequency threads will have more information as it becomes known. You can count on that!

 

[jimH]

Just the fact that they recently received financial investment from GV is an encouraging sign. They wouldn't invest in a company and it's ideas unless they believed that they were credible and showed promise for the future.:

https://decibeltx.com/wp-content/uploads/2017/07/GV-Press-Release_7.6.17_FINAL.pdf

https://www.gv.com/team/

 

[linearb]

Just the fact that they recently received financial investment from GV is an encouraging sign. They wouldn't invest in a company and it's ideas unless they believed that they were credible and showed promise for the future.

I agree, but do keep in mind that the general VC model is to bet on stuff expecting 90% of it to fail, 9% of it to maybe make your money back, and 1% of it to do so well that it pays for the 90% that failed and then some. So, looking at it from that point of view, Alphabet thinks its 1 in 100 or better than Decibel will make a lot of money.

e: to be clear, I do think there's been enough real progress in this area to expect that at some point within the next several decades* there will be hearing regenerative therapies that work for some people. But, whether any of the exact drugs and approaches that are in the pipeline right now will pan out, is anyone's guess.

* this assumes that global instability and climate change do not accelerate to the point where scientific progress halts; this may not be a safe assumption.

 

[IvanRus]

From this interview, I suggested that they consider ototoxicity from the point of view of "prevention", prevention, in the treatment of various ototoxic drugs (aminoglycosides, cisplatin, etc.), and not restoration (regeneration) of hearing loss after the already existing ototoxic damage. If so, then it grieves. I wrote to many companies related to the study of tinnitus and hearing loss, in particular, I was already interested in hearing loss due to ototoxic drugs. But all companies are engaged only in search, preventing ototoxicity, but no more. I also wrote a letter "Decibel terapeutucs" and they answered me very closed. They were advised to subscribe to their twitter. Let's all subscribe, so that they see that their work is necessary for us, and thus we will motivate them! ps. so what about real regeneration while you can talk only in the case of companies "Frequency terapeuticus", or are there any other companies in the world?
Here is the answer to my letter -
"Thank you for your email. Decibel is an early stage company developing drugs for a wide variety of hearing losses through many curative mechanisms. For the purposes of confidentiality, I cannot be more specific about our indications, targets, or timelines. I invite you to keep up with the latest at Decibel byfollowing us on Twitter (@DecibelTx)."

 

[parsky]

From this interview, I suggested that they consider ototoxicity from the point of view of "prevention", prevention, in the treatment of various ototoxic drugs (aminoglycosides, cisplatin, etc.), and not restoration (regeneration) of hearing loss after the already existing ototoxic damage. If so, then it grieves. I wrote to many companies related to the study of tinnitus and hearing loss, in particular, I was already interested in hearing loss due to ototoxic drugs. But all companies are engaged only in search, preventing ototoxicity, but no more. I also wrote a letter "Decibel terapeutucs" and they answered me very closed. They were advised to subscribe to their twitter. Let's all subscribe, so that they see that their work is necessary for us, and thus we will motivate them! ps. so what about real regeneration while you can talk only in the case of companies "Frequency terapeuticus", or are there any other companies in the world?
Here is the answer to my letter -
"Thank you for your email. Decibel is an early stage company developing drugs for a wide variety of hearing losses through many curative mechanisms. For the purposes of confidentiality, I cannot be more specific about our indications, targets, or timelines. I invite you to keep up with the latest at Decibel byfollowing us on Twitter (@DecibelTx)."

I suspect we won't hear much from any of these companies because they are all trying to be the first to market. We might get an update after a trial has been complete. Decibel hasn't even started a trial so it would appear they are behind.

 

[IvanRus]

I suspect we won't hear much from any of these companies because they are all trying to be the first to market. We might get an update after a trial has been complete. Decibel hasn't even started a trial so it would appear they are behind.

Excuse me, what kind of legal proceedings are we talking about? There are no more such large companies working on regeneration in the world, except frequency and decibel terapeutics? Do you know anything about the treatment of ototoxicity from these companies?

 

[Benoves]

Would Love to See these companies Working together and share experience..

 

[Reinier]

Let's all subscribe, so that they see that their work is necessary for us, and thus we will motivate them!

I am following them now on Linkedin. Surprisingly Frequency therapeutics only has 317 followers. Decibel therapeutics has 1207 followers. Also not a lot.

 

[parsky]

Excuse me, what kind of legal proceedings are we talking about? There are no more such large companies working on regeneration in the world, except frequency and decibel terapeutics? Do you know anything about the treatment of ototoxicity from these companies?

Generally if you are conducting a clinical trial, you don't talk about until the trial has been closed.

 

[Wojtek Kalka]

Press release from yesterday

 

[jeff W]

if they can solve the problem of ototoxic medications creating issues for tinnitus patients, then I would be beyond happy.

A few times now I have had major spikes because of those medications and because I did not know they where ototoxic. So to have something to prevent further damage would already be a HUGE relief and blessing.

Just a quick shout out to Cheng & Ricci for their achievement in this field