Isn't There a Tinnitus Cure? Induced Pluripotent Stem Cells Cure Tinnitus, Right?

[Apocalypse77]

Induced Pluripotent Stem Cells cure tinnitus, right?

I have read some stories online and even here about people whose tinnitus got cured by stem cells.

Guess I will wait until they are legalized in EU so I can go to bars (and of course bring earplugs with me while there )

Please correct me if I am wrong about this. Thanks!

 

[GregCA]

Induced Pluripotent Stem Cells cure tinnitus, right?

Source?

I have read some stories online and even here about people whose tinnitus got cured by stem cells.

I mean, scientific source?

 

[Bill Bauer]

Guess I will wait until they are legalized in EU so I can go to bars

What kind of risk will you be willing to live with? Would you go to bars if there was a 1 in 10 chance that your tinnitus will be like it was during the first month of your tinnitus, and stay like that for the rest of your life? Would a 1 in 100 chance be acceptable to you?

 

[InfiniteLoop]

@Apocalypse77

I heard online that Thanos can cure tinnitus when he is in a good mood. In the meantime, enjoy the uniqueness and hidden beauty of your own neurons making brain noise.

 

[Allan1967]

@Apocalypse77

I heard online that Thanos can cure tinnitus when he is in a good mood. In the meantime, enjoy the uniqueness and hidden beauty of your own neurons making brain noise.

I'd give my neurons a good kicking if I could.

 

[Arseny]

Can you give a link or do you know who does this?
Do you know where it's legal?
Are you talking about intratympanic injections?

 

[Bill Bauer]

I'd give my neurons a good kicking if I could.

I remember how several months into this ordeal, I was considering tazering my head in the hope of getting those neurons to snap out of it.

I know that over 20 years ago, brain cancer patients receiving radiotherapy could count on doctors being able to burn out any region of the brain they wanted, with great precision. I also know that researchers know what neural networks cause tinnitus (and their exact location). So I am not sure why they couldn't just use radiotherapy to help us.

I proposed asking the doctor they interviewed for the podcast, this question, but I guess the interviewer didn't think it was a serious question. I think that the only reason we can't get this treatment is that we are not being taken seriously. The doctors know that radiotherapy has the potential to have serious side effects. They are willing to still try it for a life-or-death cases of brain cancer patients. They don't think our cases are life-or-death, they think its just a bit of a nuisance noise.

 

[JohnAdams]

Induced Pluripotent Stem Cells cure tinnitus, right?

I have read some stories online and even here about people whose tinnitus got cured by stem cells.

Guess I will wait until they are legalized in EU so I can go to bars (and of course bring earplugs with me while there )

Please correct me if I am wrong about this. Thanks!

There are also experiments involving human clinical trials that showed insulin like growth factor 1 can restore hearing loss.

 

[Contrast]

Proven methods other then pluri-potent stem cells to restore hearing

1: Gene therapies to convert progenitor cells's into hair cells
2: Naturally activating progenitor cells convert into hair cells via "Frequency Therapeutics" method
3: Insulin Growth Factors to regenerate cochlear hair cells
4: Neutrophin 3 to regenerate cochlear ribbon synapses


Unproven methods that are being heavily questioned
1: Low Level Laser Therapy


The second method is what I believe is the most effective and Frequency Therapeutics will probably succeed at regenerating hair cells in the clinic.

Recent research has shown that regenerating ribbon synapses (fixing hearing loss in background noise) may be more important as it is far more common for one to have a hearing deficit in background noise then losing the ability to hear a frequency entirely.

So most cases of noise induced hearing loss are caused by denerved hair cells not hair cells dying, that's a hard reality for Frequency Therapeutics or the usefulness of hair cell regeneration.

 

[Contrast]

The fact that there are several different ways to get hair cells to regenerate is fascinating, at one point in evolutionarly history mammals must have had the ability to regenerate cochleair hair cells like reptiles but lost it. Yet the ability is still hardwired in mammalian genes but turned off.

Scientist should test if offshoot mammals like kanagroo or platypus can regenerate cochlear hair cells.

 

[JohnAdams]

platypus

leave him out of this.

 

[acute]

I also know that researchers know what neural networks cause tinnitus (and their exact location)

https://www.parasym.co/tVNS-deactivates-tinnitus-brain-regions.html

 

[mrbrightside614]

There are also experiments involving human clinical trials that showed insulin like growth factor 1 can restore hearing loss.

I imagine these were administered intratympanically? I used IGF in the past for bodybuilding purposes so I at least (used to) have a reliable source.

 

[mrbrightside614]

https://www.parasym.co/tVNS-deactivates-tinnitus-brain-regions.html

Correct me if I'm wrong, but isn't this completely aside from Shore's mode of stimulation? The effect on THI and wellbeing are from a study done in 2013. Why aren't more people pursuing this?

 

[MattS]

Correct me if I'm wrong, but isn't this completely aside from Shore's mode of stimulation? The effect on THI and wellbeing are from a study done in 2013. Why aren't more people pursuing this?

A very recent study just came it and had been summarized in the treatment-tDCS thread. It demonstrated that tRNS made 27% if tinnitus sufferers better, and 20% worse. Pretty poor odds there.

 

[astaff14]

Correct me if I'm wrong, but isn't this completely aside from Shore's mode of stimulation? The effect on THI and wellbeing are from a study done in 2013. Why aren't more people pursuing this?

This seems promising, I wonder if anyone here has done this treatment? Any results?

 

[mrbrightside614]

A very recent study just came it and had been summarized in the treatment-tDCS thread. It demonstrated that tRNS made 27% if tinnitus sufferers better, and 20% worse. Pretty poor odds there.

Well, Christ. Was this in just behavior related measures or actual tinnitus severity? Still, wouldn't roll those dice. Probably could destroy residual habituation, as I feel LLLT may be doing.

 

[MattS]

Well, Christ. Was this in just behavior related measures or actual tinnitus severity? Still, wouldn't roll those dice. Probably could destroy residual habituation, as I feel LLLT may be doing.

I can't remember what the primary outcome measure was. It was a small study, so perhaps not conclusive. But it was rigorous, by a good team of researchers (I know [of] one of them, as he does some non-tinnitus work in my field as well). So I'd be willing to trust this finding more than most.

Sorry for the bad news.

 

[mrbrightside614]

Not at all, appreciate the full disclosure.

 

[mrbrightside614]

Contacted Stem Cells 21 to clarify whether they still treat tinnitus patients. Interestingly, they threw this in at the end: