List of Companies and Compounds in Trials for Tinnitus and Hearing Loss

[nills]

UPDATE in 2017: Check this thread for latest information.

Source: Selected drugs in development for hearing loss indications

Anyone heard of neramexane? the compound in phase 3 trial for Tinnitus?

 

[Markku]

Anyone heard of neramexane? the compound in phase 3 trial for Tinnitus?

https://www.tinnitustalk.com/threads/treatment-prospects-neramexane.32/

https://www.tinnitustalk.com/threads/neramexane-for-tinnitus.1334/#post-10926

Another drug (probably) bites the dust....

From their website, Merz notes it is no longer actively involved in Neramexane, but is still functioning in a supportive role. I believe this pertains to a "clinical study" with a drug partner in Japan:

http://www.merz.com/research_and_development/neramexane_tinnitus/neramexane/index.jsp

From their annual report, 2012, Merz wrote their phrase III clinical trial failed to demonstrate significant amelioration of tinnitus symptoms, i.e., the drug did not meet standards necessary for approval.

http://download.merz.de/media/publi...pdf/en/EN_Merz_GB11-12_01-Umschlag_121122.pdf

 

[Erlend]

Why do I keep seeing Autofony's drug described to treat "Age-related hearing loss Tinnitus"

Isn't their drug thought to work for people with noise exposure T?

 

[nills]

True Markku, forgot about that one ... yes it is also for noise induced hearing loss Erlend. Must be age related + Tinnitus.

 

[NeoM]

Why do I keep seeing Autofony's drug described to treat "Age-related hearing loss Tinnitus"

Isn't their drug thought to work for people with noise exposure T?

I think it's aimed to treat both presbycusis (age related) and tinnitus. Something about it's mechanisms of action or something like that.

 

[demi]

Today I got an email from the guy who runs the tinnitus support group I looked into going to, and he sent this out...

"THIS IS THE BIGGEST NEWS IN 20 YEARS OF TINNITUS RESEARCH, 7 pharmaceutical companies ARE IN FINAL STAGES OF FDA CLEARED DRUGS TO TREAT TINNITUS AND HEARING LOSS. THESE DRUGS ARE AMIED AT TREATING THE CAUSE OF THE PHANTOM SOUND THAT is produced by our brains.. The drugs are aimed at the section of the brain in the audio cortex … which has hyperactive and synchronized spontaneously firing neurons. This is an abnormal state that people with tinnitus have and the brain can not go back to the resting state. These new drugs will break up that cycle.. And return the brain to its normal resting state…..eliminating the tinnitus.

One of these companies just received $50 million dollars as an investment form venture capitalist company. The only reason an investment of that size would be because of real evidence of the drug working. It was not a donation but an investment to bring to market and make a return on there money in the form of profits….NOT CHARITY!!!!!"

Anyone know about these?

 

[cullenbohannon]

Maybe you should email they guy back. Ask for more details. First I'm hearing about anything like this.

 

[cmurem]

Today I got an email from the guy who runs the tinnitus support group I looked into going to, and he sent this out...

"THIS IS THE BIGGEST NEWS IN 20 YEARS OF TINNITUS RESEARCH, 7 pharmaceutical companies ARE IN FINAL STAGES OF FDA CLEARED DRUGS TO TREAT TINNITUS AND HEARING LOSS. THESE DRUGS ARE AMIED AT TREATING THE CAUSE OF THE PHANTOM SOUND THAT is produced by our brains.. The drugs are aimed at the section of the brain in the audio cortex … which has hyperactive and synchronized spontaneously firing neurons. This is an abnormal state that people with tinnitus have and the brain can not go back to the resting state. These new drugs will break up that cycle.. And return the brain to its normal resting state…..eliminating the tinnitus.

One of these companies just received $50 million dollars as an investment form venture capitalist company. The only reason an investment of that size would be because of real evidence of the drug working. It was not a donation but an investment to bring to market and make a return on there money in the form of profits….NOT CHARITY!!!!!"

Anyone know about these?

In my opinion the collaboration of 7 pharmaceutical companies is an absurd thing..As we already know there is a collaboration of some institutes about hearing loss called Hearing Loss Project. Maybe he referred to this project group with an exaggeration.

 

[NeoM]

In my opinion the collaboration of 7 pharmaceutical companies is an absurd thing..As we already know there is a collaboration of some institutes about hearing loss called Hearing Loss Project. Maybe he referred to this project group with an exaggeration.

I don't think the e-mail was suggesting a collaboration, but instead that there are just seven pharmaceutical companies working on tinnitus related drugs.

I really only know one drug that's in the late stage of trials, i.e. AM-101.

 

[Grace]

I don't think the e-mail was suggesting a collaboration, but instead that there are just seven pharmaceutical companies working on tinnitus related drugs.

I really only know one drug that's in the late stage of trials, i.e. AM-101.

Are they saying other then am101 and aut00063 that theres other drugs in the works too that we dont know about?! Confused

 

[demi]

So, I got another emailing saying this:

"For those who have been inquiring about where the information on tinnitus drugs I sent out came from, the person who relayed this information to me, and who was just trying to offer us hope, got it from a website called tinnitustalk.com I checked out the website. It exists. You can search for the information on that website and look up each company."

I don't think anywhere on here we have talked about there being that many companies about to come out with anything besides AM101.

 

[Hudson]

So, I got another emailing saying this:

"For those who have been inquiring about where the information on tinnitus drugs I sent out came from, the person who relayed this information to me, and who was just trying to offer us hope, got it from a website called tinnitustalk.com I checked out the website. It exists. You can search for the information on that website and look up each company."

I don't think anywhere on here we have talked about there being that many companies about to come out with anything besides AM101.

Are we that mythical of a place on the internet? Our information comes from the internet typically, either that or members email researchers themselves. lol

 

[Grace]

Are we that mythical of a place on the internet? Our information comes from the internet typically, either that or members email researchers themselves. lol

Tinnitus talk is the next facebook of tinnitus! Lol such an amazing site tho!

 

[NeoM]

Are we that mythical of a place on the internet? Our information comes from the internet typically, either that or members email researchers themselves. lol

Kind of makes me wonder if there was a rumor started on here if it would spread...Drink your own urine to cure tinnitus! (that's a joke people, please don't try it)

 

[Grace]

Kind of makes me wonder if there was a rumor started on here if it would spread...Drink your own urine to cure tinnitus! (that's a joke people, please don't try it)

Bahahah i wish it was that simple... The gross things we T people would do to get rid of T completely.. Idc what it would be i would most likely do it lol

 

[nills]

I have sipped the golden fountain ... rather sweet if live on a diet of fruits and vegies ... quit discusting if you had McDonalds the day before! very healthy practice actually

 

[matthew heafield]

This looks very promising, we could be extremely close to getting some sort of cure in the next year.

 

[dan]

This looks very promising, we could be extremely close to getting some sort of cure in the next year.

What is promising?

 

[dan]

So, I got another emailing saying this:

"For those who have been inquiring about where the information on tinnitus drugs I sent out came from, the person who relayed this information to me, and who was just trying to offer us hope, got it from a website called tinnitustalk.com I checked out the website. It exists. You can search for the information on that website and look up each company."

hahahahahaa - It exists! We are giving hope to millions and they are giving us our hope right back to us

 

[attheedgeofscience]

I have sipped the golden fountain ... rather sweet if live on a diet of fruits and vegies ... quit discusting if you had McDonalds the day before! very healthy practice actually

I think I will call it "a pass" on this particular remedy (even though I been known - and willing - to take a few risks every now and then in the search for a cure...).

What I can say is that in "the old days", doctors would occasionally taste the urine of patients because an abnormal taste would reveal potential for certain diseases. To tell which one, you would have to be a connaisseur, I guess . Glad not to be doctor, now or back then...

 

[matthew heafield]

What is promising?

All of the above research that are in either phase 2/3 of trials looks promising.

 

[ResonanceCEO]

View attachment 865

Source: Selected drugs in development for hearing loss indications

Anyone heard of neramexane? the compound in phase 3 trial for Tinnitus?

Nice list Nills! I'm going to have to use this one.

 

[dan]

Neramexane tanked, idk why is it still on the list.