Master Spreadsheet of Hearing Pipeline

[weab00]

Good news everyone.

CRISPR Breakthrough: Scientists Can Now Turn Genes On and Off at Whim

Typical pop science journalism.

It doesn't let scientists turn genes on and off at will. Firstly, it doesn't work for all genes, and even for the genes it works for it doesn't turn them off completely but rather lowers their activity significantly. They're also considerably worse at turning genes back on after turning them off. Additionally, it's really difficult to actually activate this system. They're working in cultured cell lines it hasn't even been tested in mice or anything related, in fact, editing genes in a mature organism is almost impossible with current technology.

They also didn't try and turn on any genes they haven't previously turned off which is another question.

This technology significant for science, but it's not necessarily a landmark. The first paper to epigenetically silence genes using modified CRISPR/dCas9 via DNA methylation was published in 2016.

Editing DNA methylation in the mammalian genome

I think it's important to watch out for these sensationalized headlines.

 

[Zugzug]

I just updated it with many of the suggestions.

 

[Tezcatlipoca]

I just updated it with many of the suggestions.

Hough Ear Institute's hair cell regeneration drug is called AOK-1.

 

[OptimusPrimed]

This is a great spreadsheet; but it needs to be updated... Bionics institute, Curtin University, Acousia Therapeutics, Strekin AG... among others making efforts to treat hearing loss and tinnitus.

 

[Gabriel5050]

@Zugzug, it would be nice if you updated this again, or is tinnitus research really moving this slow?

 

[Brian Newman]

@Zugzug, it would be nice if you updated this again, or is tinnitus research really moving this slow?

He's waiting for the trial results coming out in a month or two. OTO-413, OTO-313, and a few others in a couple of months as well.