My Posting Place
- Thread starter threefirefour
- Start date
Member
Severe tinnitus is the illness with the largest gap between patients' actual suffering, and the medical field's perception of the need for a cure. Thanks Jastreboff.
I don't know if this is true but it sure seems like it.
I don't know if this is true but it sure seems like it.
Last edited:
My brain does not want to acknowledge that I'm fcked but I'll need to force it for the most utilitarian outcome.
Why is there so little information about tinnitus. It's like I'm stuck with suffering but people don't really understand because they think ringing in the ears is some joke that happens only to old people
Deathtotinni
Member
- Dec 21, 2017
- 157
- Tinnitus Since
- 9/10/17
- Cause of Tinnitus
- Qtip and maybe a sound..who knows
Nope didn't get in. Blood pressure was high from walking or flying in and screening right after. Pretty upset and pissed off.
Good thing is, is that the next study is in 9-12 months and will be much larger. They still haven't seen any side effects and I think it's very unlikely to cause cancer at any point. Gene therapy maybe, but this drug to me from the outside and not being a damn scientist, looks pretty safe.
Good thing is, is that the next study is in 9-12 months and will be much larger. They still haven't seen any side effects and I think it's very unlikely to cause cancer at any point. Gene therapy maybe, but this drug to me from the outside and not being a damn scientist, looks pretty safe.
@PolishSoldier87 found this graph.
It looks like at the right dose that curcumin actually does increase atoh1 expression up to around 45% of that of the control group. Can anyone else here interpret what micro (M) means? Micro molar? That seems like a very low does, even taken orally. I'm thinking maybe if you could boost this with celastrol, that there could possibly be something to this.
It looks like at the right dose that curcumin actually does increase atoh1 expression up to around 45% of that of the control group. Can anyone else here interpret what micro (M) means? Micro molar? That seems like a very low does, even taken orally. I'm thinking maybe if you could boost this with celastrol, that there could possibly be something to this.
PolishSoldier87
Member
- Jan 16, 2018
- 209
- Tinnitus Since
- 12/2017
- Cause of Tinnitus
- acustic trauma, neuro-lyme/rx co-op toxins
No. Atoh1 was expressing because there were reconstructed conditions of developing cochlea. Curcumin was just factor which presence stopped expression od Atoh1. Then it was reversed.
"To test the contribution of ongoing acetylation to hair cell differentiation, HATi was removed from some cultures at the 24 h time point. These washout experiments demonstrated that changes brought about by HATi were reversible, and differentiation resumed upon drug removal."
Attachments
9-12 months? That's ridiculous, especially if it's safe. If these people are working 8 hour days 5 days a week, what in the world could they possibly be doing?
Last years study: it was safe
This years study: it's safe again.
9-12 months later phase 2a: does it work?
X months later: does it work again?
They could answer this question in like 2 months for us. They will know. If you're right then this is complete insanity. It shows a complete lack of urgency and empathy for us. If it's safe what is the deal? Isnt the whole purpose of the FDA to just make sure these drugs dont harm us? It is safe. Next. Does it work??????
PolishSoldier87
Member
- Jan 16, 2018
- 209
- Tinnitus Since
- 12/2017
- Cause of Tinnitus
- acustic trauma, neuro-lyme/rx co-op toxins
Moreover it seems that curcumin is otoprotective If taken before trauma.
https://www.sciencedirect.com/science/article/pii/S1347861317301093
But after trauma if you take it, spontaneus regeneration (which is miserable itself) wont occur due to lack of Atoh1 expression.
"We have shown that the response of cells in the utricle to an ototoxic trauma involve changes of Notch signaling molecules and Atoh1 expression. Using qRTPCR we detected down-regulation of Hes5, up-regulation of Atoh1 and no changes in levels of Notch1, Jagged1 and Hes1
Atoh1 was not detected in the normal tissue but appeared after the trauma. qRTPCR data showed a post trauma decrease for Hes5 and an increase in Atoh1 after the lesion, with no significant change in Notch1, Jagged1 and Hes1."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902641/
I think this is my first serious conclusion on this forum.
Last edited:
piss easy, inspect element o change text + paste any image you want over the profile pic.
- May 29, 2018
- 1,161
- Tinnitus Since
- 10/2017
- Cause of Tinnitus
- Neck/stress
https://www.tinnitustalk.com/thread...yperacusis-seminar-summary.15607/#post-185018 this comment explains things perfectly.
winner it!
winner it!
- May 29, 2018
- 1,161
- Tinnitus Since
- 10/2017
- Cause of Tinnitus
- Neck/stress
There will be an update posted in Mutebutton thread regarding Neuromod today (or tomorrow). I don't know what it is, but Steve will be sharing some information with us. Just thought I would let yall know.
no, not so fast. this is bullshit dude.
stubbing your toe and having pain isn't the same thing as losing a toe and having the brain's mapping still detect phantom signals. There is a difference between central and peripheral pain.
That doesn't mean that fixing the peripheral issue will not help.
I fully agree that fixing the peripheral issue will indeed fix the problem of tinnitus in most cases. I'm just being silly.
Log in or register to get the full forum benefits!
Similar threads
