My Posting Place

[JohnAdams]

This what the process should be:

1. Discovers drug, therapy treats X disease
2. Publish a Paper
3. Doctor tells patient and patient signs a risk waiver and gets it

Total time: Less than a year.


This what the process is.

1. Discovers Dexamethasone can help Meniere's disease
2. Big pharma companies analyze the market.
3. Big pharma decides how to proprietize medical treatment
4. Big pharma seeks more investors
5. Begin preclinical trials
6. Look for more investors
7. Apply to FDA for clinical trials
8. Recruit for trial
9. Begin trial phase 1
10. Submit trial data for review
11. Wait for FDA to review data
12. Repeat steps 7-11 up to 6 times
13. Get FDA approval
14. Market drug
15. Patient gets drug/treatment

Total time: 4-10 years

 

[Agatha]

This what the process should be:

1. Discovers drug, therapy treats X disease
2. Publish a Paper
3. Doctor tells patient and patient signs a risk waiver and gets it

Sometimes I can't believe you have managed to graduate with a biomedical degree.

Where are the crucial clinical trial phases that investigate safety and efficacy of the drug? Those three phases take on average 8-12 years.

If you don't value your health, fine, but you're acting reckless.

 

[JohnAdams]

Sometimes I can't believe you have managed to graduate with a biomedical degree.

Where are the crucial clinical trial phases that investigate safety and efficacy of the drug? Those three phases take on average 8-12 years.

If you don't value your health, fine, but you're acting reckless.

Right off the bat with an ad-hominem attack. You're good at those.

I've had IT dex shots. I had one yesterday. Why should they have to get this through an entire round of FDA trials? Oh yeah, there's no good reason. Any other words of wisdom from you?

 

[JohnAdams]

Guys, @Contrast has been right all along. Most of us have damaged cochlear synapses, not dead hair cells. We dont need FX-322, we need NT-3 and BDNF, and PRP.

 

[Ray552]

Guys, @Contrast has been right all along. Most of us have damaged cochlear synapses, not dead hair cells. We dont need FX-322, we need NT-3 and BDNF, and PRP.

So prp regenerates the synapses? And doesn't prp push for the generation of new hair cells regardless?

 

[GSC]

Are we sure fx-322 won't regenerate synapses? I thought one of their achievements was speech in noise/word recognition which lie primarily in synapses?

 

[GSC]

This is my question, if fx-322 hits the notch that enables hair cell growth and regeneration. Why wouldn't it regenerate everything once that notch is on?

 

[Kain]

i need anything at this point

 

[Manny]

This is my question, if fx-322 hits the notch that enables hair cell growth and regeneration. Why wouldn't it regenerate everything once that notch is on?

I know nothing but the notch/effect is obviously localized, so perhaps it is localized exclusively or at least mostly to the hair cells.

 

[GSC]

@Kain You would benefit from fx-322.

 

[GSC]

velma voice, from scooby doo: my synapses... my synapses.. i can't find my synapses..

 

[Kain]

@Kain You would benefit from fx-322.

shit it i hope i do, and it better get here fast too. or i'm swinging at the company (ง'̀-'́)ง

 

[GSC]

shit it i hope i do, and it better get here fast too. or i'm swinging at the company (ง'̀-'́)ง

You have mild hearing loss... I think you would.

 

[Kain]

You have mild hearing loss... I think you would.

we'll find out when i get another audiogram done

 

[JohnAdams]

So prp regenerates the synapses? And doesn't prp push for the generation of new hair cells regardless?

That's a good question. I will get back to you on that one.

 

[Contrast]

This is my question, if fx-322 hits the notch that enables hair cell growth and regeneration. Why wouldn't it regenerate everything once that notch is on?

the progeintor cells only know how to do two things.

1: Duplicate
2: Grow new hair cells

 

[JohnAdams]

the progeintor cells only know how to do two things.

1: Duplicate
2: Grow new hair cells

Robert Jackler from Stanford university, where they discovered all of this, said that once the hair cell regrows, the nerves regrow and reconnect. It's probable because the functioning hair cell secretes neurotransmitters that induce the nerve to look for a connection to make.

 

[GSC]

Robert Jackler from Stanford university, where they discovered all of this, said that once the hair cell regrows, the nerves regrow and reconnect. It's probable because the functioning hair cell secretes neurotransmitters that induce the nerve to look for a connection to make.

Yeah, I know. So - why wouldn't fx-322 not be able to restore synapses as well if that is true?

 

[JohnAdams]

Yeah, I know. So - why wouldn't fx-322 not be able to restore synapses as well if that is true?

I'm eagerly awaiting them to publish their trial data. Maybe their drug doesn't just regrow hair cells, but like you said, regenerates everything.

 

[GSC]

I'm eagerly awaiting them to publish their trial data. Maybe their drug doesn't just regrow hair cells, but like you said, regenerates everything.

I really hope it does, because the improvement of word recognition. But that could be just a matter of decibels regained.

 

[Jiri]

Thanks. I ate the cream and took a bunch of antioxidants inlcuding those. I'm afraid my tinnitus has permanently increased a little bit but not too bad.

Yo, good to hear it's not too bad. It may not even be a permanent increase. Don't eat topical corticosteroids.

 

[JohnAdams]

So.... they know IT injections of NT-3 can regrow cochlear synapses.

https://www.researchgate.net/public...cochlear_synapses_after_acoustic_overexposure

Also BDNF/7,8 DHF .....
https://news.usc.edu/140224/new-study-shows-hope-for-hearing-loss/


Why can't ENT's in America just go ahead and load this stuff up in a syringe and inject it into a tinnitus sufferer's eardrum? It is safe.

Things like this should be the point of existence of the ATA and BTA, to actually research and advocate that effective therapies at least be tried ASAP. Instead they just go around doing NOTHING productive and WASTING funds on nonsense waiting for some corporation to dance their waltz with the government. They are not doing their jobs effectively. By being the organizations that they are and NOT doing this I am accusing them of having blood on their hands from all the suicides that have occurred from debilitating tinnitus in the last few years since these studies were published.

 

[GSC]

By being the organizations that they are and NOT doing this I am accusing them of having blood on their hands from all the suicides that have occurred from debilitating tinnitus in the last few years since these studies were published.

 

[JohnAdams]

View attachment 29454

If they aren't going to actually research these things while corporations do all the legwork and actually be our advocates then they need to drop their names, stop calling themselves tinnitus associations, and find new jobs.

If it turns out that these things actually do work to quiet tinnitus in the future, then I will be vindicated about that statement because that means they did nothing to help and they have self appointed themselves as advocates.

So let's just wait and see. I know I will be right. I was right about FX-322 working last year when smart guys were arguing with me like morons about it. This really pisses me off because some people are trapped in a torture dungeon of loud piercing tinnitus and these "associations" aren't doing ANYTHING to expedite relief for them and many of them will kill themselves before these drugs and treatments are released.

It's just like the breastcancer advocacy group Susan G Komen taking their money and instead of using it all to fund research for a cure, they have used some of it in the past to sue other cancer groups for using the color pink in their own cancer fundraising drives.

" In addition, they are warning cancer charities to stay away from using any pink in marketing efforts. To drive their point home, they recently announced a lawsuit to protect their marketing phrase and color use."

https://ssir.org/articles/entry/suing_for_the_cure

So where does being fucking EVIL assholes and suing people for using the color pink fall in this chart?
Mission? Fundraising? Admin?

They also have blood on their hands for this. Diseases are serious business, life and death. To get into that world comes with a lot of responsibility, to actually help people.

The BTA needs to wake up and stop funding nonsense. Every dollar spent on crap like that is one dollar not spent on something that will cure sufferers.

Imagine if Susan G Komen funded a "mindfulness" study for dying of cancer. Same thing.

 

[Liam_Cairns]

And notice they are giving it a new name so normies think that they invented some kind of super special drug when really they just put up the money to get it approved for treating meniere's disease. It's a slimy disgusting system that is illogical and keeps pharma companies in the money.

Watch "Otividex" will cost 10x more than off the shelf dexamethasone and no ENT will use dexamethasone to treat meniere's disease unless it is labeled Otividex, even though it's the same exact thing. Just watch.

It's a sustained release tho, that is a difference, like AM101 isn't just esketamine, its esketamine that releases in a very slow manner. This isn't the same as renaming antidepressants after slightly tweaking them or isolating their active metabolites. Now I don't know enough but I reckon that a sustained release would make a big difference.

 

[Contrast]

 

[JohnAdams]

sustained relea

Sustained release = mixed with hydrogel?

 

[IvanRus]

It's a sustained release tho, that is a difference, like AM101 isn't just esketamine, its esketamine that releases in a very slow manner. This isn't the same as renaming antidepressants after slightly tweaking them or isolating their active metabolites. Now I don't know enough but I reckon that a sustained release would make a big difference.

Greetings, buddy! How are you? How is your tinnitus?
I read, did you say that taking prednisone ruined your leg? Can you tell us more about this?

 

[Contrast]

SO HYPE!

 

[Contrast]

The FDA is sending over an inspector to ZenithLabs

pic above is the inspector