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- Thread starter threefirefour
- Start date
Phendran
Member
(By answering this do I confirm myself as a slut? Could be worse I guess.)
It's hard to tell sometimes. From where I sit most of you seem to champion our cause energetically.
I'm waiting for the fancy administrative court over here to assess whether or not I will be allowed to call myself a sick citizen.
The judicature has been helpful so far, but I expect they know as much about tinnitus as most regular people.
When that's done and over with I plan to contact the local hospital and see if I can talk to someone that knows about PRP. @JohnAdams has been very helpful.
I'd like to see if I could find someone around here willing to get some marrow out of me and put it somewhere else.
I'd like to hit upon something tangible, instead of only spouting poetry your way that doesn't really help our cause much.
Sleeping would also be nice. I'll attempt it right now.
Member
You probably saw the article about the University of Arizona finding a possible treatment by targeting neuroinflammation in mice. If their finding translates to humans and is safe, it could be less than one.
Ken219
Member
Hey Y'all, I'm very much alive! Like @Daniel Lion said I've been out riding, met a girl, and have been working a lot.
My tinnitus has mostly been at the back of the bus. Over the last 2 months I've had 3 or 4 very bad days. I feel blessed that this has happened to me as my relentless mega high pitch tinnitus is lower but also bothers me WAY less now. For the newbies here I've had Tinnitus for over 2.5 years now.
@Jack Straw Thanks for your concern man, I still log in here everyday but now that Lenire has released I'm just checking in on that and also excited! It feels like there might be a light at the end of the tunnel!
Hope everyone is doing well!
My tinnitus has mostly been at the back of the bus. Over the last 2 months I've had 3 or 4 very bad days. I feel blessed that this has happened to me as my relentless mega high pitch tinnitus is lower but also bothers me WAY less now. For the newbies here I've had Tinnitus for over 2.5 years now.
@Jack Straw Thanks for your concern man, I still log in here everyday but now that Lenire has released I'm just checking in on that and also excited! It feels like there might be a light at the end of the tunnel!
Hope everyone is doing well!
Ken219
Member
Good for you man. I'm happy for you, and also jealous. Hope Lenire might help me and all of us.
ajc
Member
- Feb 6, 2018
- 1,170
- Tinnitus Since
- 11/2002; spike 2009; worse 2017-18
- Cause of Tinnitus
- Loud music - noise damage
I think there are 5 types of tinnitus:
1. Mechanical induced neuro-dysfunctional tinnitus
- TMJ
- cervical
- etc.
2. Neuropathic induced neuro-dysfunctional tinnitus
- auditory nerve damage
- synapse damage
3. Non-cochlear stimulus deprivation induced tinnitus
-Earwax blockage
-Glue ear blockage
-middle ear bone defects, damage
- tympanic membrane dysfunction, damage, perforation
4. Cochlear stimulus deprivation induced tinnitus
- loss of the hair cell
5. Auditory cortex damage induced tinnitus
- damage to the auditory cortex.
The presence of tinnitus is not limited to any single one of these etiologies. There's your subtypes.
A pure tonal hearing test combined with a speech in noise test should be able to help distinguish between 2 and 4 in some cases. The rest should be able to be diagnosed with an ear exam or an MRI or fMRI.
Anyone care to elaborate on this?
1. Mechanical induced neuro-dysfunctional tinnitus
- TMJ
- cervical
- etc.
2. Neuropathic induced neuro-dysfunctional tinnitus
- auditory nerve damage
- synapse damage
3. Non-cochlear stimulus deprivation induced tinnitus
-Earwax blockage
-Glue ear blockage
-middle ear bone defects, damage
- tympanic membrane dysfunction, damage, perforation
4. Cochlear stimulus deprivation induced tinnitus
- loss of the hair cell
5. Auditory cortex damage induced tinnitus
- damage to the auditory cortex.
The presence of tinnitus is not limited to any single one of these etiologies. There's your subtypes.
A pure tonal hearing test combined with a speech in noise test should be able to help distinguish between 2 and 4 in some cases. The rest should be able to be diagnosed with an ear exam or an MRI or fMRI.
Anyone care to elaborate on this?
- Jun 18, 2019
- 294
- Tinnitus Since
- 05/24/2019
- Cause of Tinnitus
- Chronic headphones use and acute noise induced trauma.
Loss of stereocillia alone does not produce tinnitus, (peripheral) neuropathy does, so point 4 is not accurate. That's also why some people suffer from hearing loss, yet don't get tinnitus. As long as the nerve endings aren't damaged, the auditory cortex doesn't produce the "phantom sound", even if the frequency isn't perceived by the cochlear.
Okay. So then in the instances of hair cell loss, you think the tinnitus signal is generated by accompanying nerve damage in every case? I am open to this.
However, this would go against the experiments showing using earplugs can generate tinnitus. Also, earwax buildup can cause tinnitus as well. So wouldn't that mean that simply losing input can generate tinnitus and therefore mean that also just losing the hair cell could also generate tinnitus?
- Jun 18, 2019
- 294
- Tinnitus Since
- 05/24/2019
- Cause of Tinnitus
- Chronic headphones use and acute noise induced trauma.
Indeed, neuropathy always induces some form of hearing loss (hidden or otherwise), and is usually accompanied by the death of its attached stereocillia, the death of a stereocillia on the other end, does not always induce neuropathy, while both cause hearing loss, neuropathy causes tinnitus.
Neuropathy can also be caused from chronic noise exposure. (As well as many other possible causes, such as acute noise trauma, inner ear infections, ototoxic medications....) this is why the line between people suffering from hearing loss but not tinnitus, and tinnitus sufferer is often blurry and misunderstood, recent biopsies however have shown a very clear correlation between neuropathy and tinnitus.
So to cure tinnitus, one would need to heal/regenerate the peripheral nerve. I do not know how successful the drugs currently undertaking clinical trials are at doing so.
- Jun 18, 2019
- 294
- Tinnitus Since
- 05/24/2019
- Cause of Tinnitus
- Chronic headphones use and acute noise induced trauma.
The thing is earplugs and earwax do not cause tinnitus per se, rather they increase the perception of an already existing underlying condition (tinnitus), which already existed in those individuals (typically from pre-existing nerve damage), in fact, losing input does not cause stereocillia's death, it does however trigger the auditory cortex into increasing its "gain" which makes everything, including an existing tinnitus, sound much louder (and can cause hyperacusis), the once unnoticed tinnitus is then percieved and the individual then focusses on it, which increases stress, which triggers a negative feedback loop which further increases the perception of tinnitus, which makes the auditory cortex focus/tune to it and so on.
Tinnitus perception itself is very complex and relies on multiple factors, the cause however is more often than not, peripheral neuropathy.
I don't think any are currently going through trials. Otonomy plans to begin trials for BDNF this year.
Do you really think PTA test is that much powerful?
I don't really know. But even researchers nowadays say that PTA is not reliable. E.g. it can't show hidden HL but an ABR test (they say) in case of HHL is more reliable. Despite all these things I think there is no method to guarantee that your hearing is 100% fine. I guess one can evaluate his hearing better than a PTA can. For example you go to an audiologist and describe your problems and he tests your hearing(lets say UHF test) and say you're ok, goodbye :| literally saying, I don't really know if we should trust them.
@JohnAdams - How about adding #6 long standing/over the top stress that triggered my T. In other words a mini snap. And throw in dental work at the same time also did something. My T is not from hearing. So, I would add #6 to your list. Not everyone fits in the top 5.
Body produced cortisol could be, I was having a difficult mental experience plus a root canal was done months back then the crown was put on pain, I had them take off crown put on temp which is still on, To me it was a mental stress snap T.
Kain
Member
- Aug 25, 2018
- 365
- 26
- Tinnitus Since
- March, 2018
- Cause of Tinnitus
- excessive loud music through earbuds
When I think of them I wanna call them those idiots but you know we would do the same if we were in their shoes.
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