My Posting Place

[Phendran]

I think we will have most cases cured in the 2020s.

Now that, my friend, that, now that, my friend, my friend, now that...
*Bizarre clearning throat-noises*

If that really happens. If. I don't even know how I would.

 

[jay777]

think we will have most cases cured in the 2020s.

What year is it now 200 BC.

 

[Marslum]

I really want to be hopeful about research into regenerating hair cells being effective in eliminating tinnitus and hyperacusis. I really, really hope for everyone on here and elsewhere that something will come up soon.

There are so many people around me who have problems with their hearing, pain and/or tinnitus, it is very unfortunate there is no solution yet.

 

[JohnAdams]

I LOVE TINNITUS TRT ™

 

[Autumnly]

@threefirefour @Autumnly
Whatever happened to the visual snow device or treatment that was supposed to come out?

 

[JohnAdams]

I'm pretty sure Neuromod people are on the Neuromod thread. Why wouldn't they be?

 

[JohnAdams]

"Brain-derived neurotrophic factor (BDNF) promotes the survival and growth of neurons during brain development and mediates activity-dependent synaptic plasticity and associated learning and memory in the adult. BDNF levels are reduced in brain regions affected in Alzheimer's, Parkinson's, and Huntington's diseases, and elevation of BDNF levels can ameliorate neuronal dysfunction and degeneration in experimental models of these diseases. Because neurons accumulate oxidative lesions in their DNA during normal activity and in neurodegenerative disorders, we determined whether and how BDNF affects the ability of neurons to cope with oxidative DNA damage. We found that BDNF protects cerebral cortical neurons against oxidative DNA damage-induced death by a mechanism involving enhanced DNA repair. BDNF stimulates DNA repair by activating cyclic AMP response element-binding protein (CREB), which, in turn, induces the expression of apurinic/apyrimidinic endonuclease 1 (APE1), a key enzyme in the base excision DNA repair pathway. Suppression of either APE1 or TrkB by RNA interference abolishes the ability of BDNF to protect neurons against oxidized DNA damage-induced death. The ability of BDNF to activate CREB and upregulate APE1 expression is abolished by shRNA of TrkB as well as inhibitors of TrkB, PI3 kinase, and Akt kinase. Voluntary running wheel exercise significantly increases levels of BDNF, activates CREB, and upregulates APE1 in the cerebral cortex and hippocampus of mice, suggesting a novel mechanism whereby exercise may protect neurons from oxidative DNA damage. Our findings reveal a previously unknown ability of BDNF to enhance DNA repair by inducing the expression of the DNA repair enzyme APE1."


https://www.ncbi.nlm.nih.gov/pubmed/24114393


That's so strange because in models of noise induced damage, BDNF is increased.


"In our study, in response to the previously shown decrease in glycinergic inhibition in aged and sound exposed DCN (Brozoski et al., 2002; Caspary et al., 2005, 2008 for review; Schatteman et al., 2008; Wang et al., 2009a, b), BDNF could enhance glutamate release at glutamatergic synapses (Carvalho et al., 2007; Mattson, 2008 for review) and directly cause neuronal hyperactivity in a short term following sound exposure."


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057525/



So BDNF can trigger neuronal repair, but also increase glutamate, which causes neuronal hyperactivity, which is tinnitus. Also glutamate can cause damage.


Any thoughts?????????????????

 

[Kain]

 

[Contrast]

remember new comers look like idiots when they have noise induced tinnitus and suspect everything but noise, that's literally the status quo. It was never a mystery just a mystery to them.

 

[JohnAdams]

Then this study says the opposite, so wth.

"Furthermore, BDNF levels are reduced in tinnitus,"

https://www.ncbi.nlm.nih.gov/pubmed/28615544

 

[JohnAdams]

wait, does up regulation mean a decrease? I may have just profoundly confused my self.

 

[JohnAdams]

I think this is right, BDNF is lower in tinnitus patients.

"Serum BDNF level was found lower in the tinnitus patients than controls"

https://www.ncbi.nlm.nih.gov/pubmed/28615544

 

[Contrast]

im trying to figure out a way to stop coming here.

 

[85dB T]

 

[Contrast]

When there finally is a cure for tinnitus, this is how Frequency and Decibel-tx are going to look in comparison to all the current day "tinnitus clinics"

 

[JohnAdams]

Literally a Russian bot

 

[Contrast]

\

 

[JohnAdams]

View attachment 31599

\

 

[JohnAdams]

 

[Contrast]

cochlear neuropathy IS a recognized diagnosis by the world health organization.
https://icd.who.int/browse11/l-m/en#/

 

[JohnAdams]

Lol I have to go for it.

 

[JohnAdams]

damnit. I couldn't get it

 

[JohnAdams]

 

[ajc]

Lol I have to go for it.
View attachment 31611

I have seen youtube videos where they put in 100s of dollars to get the toy from those machines.

It's usually like it gives a toy every 50-100 dollars put in.

 

[Marslum]

Why isn´t there more awareness about tinnitus, if there are so many who have it ?

 

[Contrast]

Lol I have to go for it.
View attachment 31611

every mistake you make gets donated to TRT clinics.

 

[JohnAdams]

 

[ChrisBoyMonkey]

"Brain-derived neurotrophic factor (BDNF) promotes the survival and growth of neurons during brain development and mediates activity-dependent synaptic plasticity and associated learning and memory in the adult. BDNF levels are reduced in brain regions affected in Alzheimer's, Parkinson's, and Huntington's diseases, and elevation of BDNF levels can ameliorate neuronal dysfunction and degeneration in experimental models of these diseases. Because neurons accumulate oxidative lesions in their DNA during normal activity and in neurodegenerative disorders, we determined whether and how BDNF affects the ability of neurons to cope with oxidative DNA damage. We found that BDNF protects cerebral cortical neurons against oxidative DNA damage-induced death by a mechanism involving enhanced DNA repair. BDNF stimulates DNA repair by activating cyclic AMP response element-binding protein (CREB), which, in turn, induces the expression of apurinic/apyrimidinic endonuclease 1 (APE1), a key enzyme in the base excision DNA repair pathway. Suppression of either APE1 or TrkB by RNA interference abolishes the ability of BDNF to protect neurons against oxidized DNA damage-induced death. The ability of BDNF to activate CREB and upregulate APE1 expression is abolished by shRNA of TrkB as well as inhibitors of TrkB, PI3 kinase, and Akt kinase. Voluntary running wheel exercise significantly increases levels of BDNF, activates CREB, and upregulates APE1 in the cerebral cortex and hippocampus of mice, suggesting a novel mechanism whereby exercise may protect neurons from oxidative DNA damage. Our findings reveal a previously unknown ability of BDNF to enhance DNA repair by inducing the expression of the DNA repair enzyme APE1."


https://www.ncbi.nlm.nih.gov/pubmed/24114393


That's so strange because in models of noise induced damage, BDNF is increased.


"In our study, in response to the previously shown decrease in glycinergic inhibition in aged and sound exposed DCN (Brozoski et al., 2002; Caspary et al., 2005, 2008 for review; Schatteman et al., 2008; Wang et al., 2009a, b), BDNF could enhance glutamate release at glutamatergic synapses (Carvalho et al., 2007; Mattson, 2008 for review) and directly cause neuronal hyperactivity in a short term following sound exposure."


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057525/



So BDNF can trigger neuronal repair, but also increase glutamate, which causes neuronal hyperactivity, which is tinnitus. Also glutamate can cause damage.


Any thoughts?????????????????

There must be balance in the force.

 

[Zeneth]

Why isn´t there more awareness about tinnitus, if there are so many who have it ?

Because it's heavily downplayed by the ones who have it mildly and for some reason feel the need to advocate for it
"not being that bad."

 

[ChrisBoyMonkey]

I'm pretty sure Neuromod people are on the Neuromod thread. Why wouldn't they be?

I'm sure they check it out every now and then because they figured we're gonna be a big group of their customers, but I doubt that they're on it making up testimonials or anything like that.