I think we'll need the full paper to come out to fully understand this graph. According to the graph, there were also people in the control arm who had similar increases. Maybe the device was not responsible for the increases. It could be that some people in the trial had tinnitus volume that varies by the day (like mine) and the graph is just catching them on a bad day. On some days I can hardly hear my tinnitus and on others it's quite loud...
Because hearing involves more than communication. Even if EHFs don't "affect communication", they are still involved in everyday sounds. Please put an EQ on your favorite song and brickwall out all the information above 8 kHz. While you will still be able to discern the lyrics, how does the rest of the piece sound to you now?
The figure I've seen (and I can't find the source for) was that 30% of people with hearing loss have tinnitus. That's purely from memory though, and I wish there was better data on the proportionality.
I just can't. So you're saying people with tinnitus and hearing loss have lesser QoL than those with just hearing loss. That doesn't mean a lot of people with hearing loss don't have tinnitus.
Not to be a Negative Nelly, but I truly think it won't help everyone, at least to an extent. While I appreciate the perspective, I would like to point out that Susan Shore's research takes into account the critical role of trigeminal somatic crossfire in determining the severity of tinnitus. This is a crucial aspect that is often overlooked when discussing the efficacy of the device. While fusiform cells in the DCN are a very important factor, it's not mutually exclusive.
Like many here, I have severe tinnitus with about 20 different tones wreaking havoc in my ears, but man I'd do anything to significantly recover from hyperacusis and noxacusis. Those are the conditions that have fully destroyed my life for the time being.
@chinup, whilst Dr. Shore's device showed good preliminary data that will help a percentage with tinnitus, regenerative medicine is decades away.
I really hope you're wrong. It seems everything will fail this decade but I'm going to wait for the FX-322 results to come out. If it fails, yeah, we won't have anything until next decade.
Yeah. I think the Michigan Device is our best shot. I cannot for the life of me see this obsession with FX-322 or whatever. Just shows how messed up we all can be.
Same here. I definitely think bimodal stimulation will be the way to go. Regenerative medicine is still far away, and for many other diseases as well. I hope to be wrong and FX-322 to be a success.
Because people hope/wish that regenerative therapies will cure them while Susan Shore's device will "only" be a treatment.
Additionally, tinnitus is only a subset of hearing loss. The Tinnitus Talk members are the minority when it comes to tinnitus, most people just don't notice it as it may be so mild or they don't care about it. But many people on here suffer multiple symptoms e.g., hyperacusis.
Well, remember they need to get the ball rolling for those regenerative drugs. It's the same thing as any other therapy or treatment, it will only help a little in the beginning, then drugs being made over time will keep getting better and better.
Humans always want more than what they have. This is not a bad thing either - it's how progress happens. If tinnitus becomes treatable with Dr. Shore's treatment, then we're all better off, but there is more work to do with auditory issues in general.
I think most people who aren't profoundly deaf just want their tinnitus to get lower or disappear.
@Brian Newman covered it quite well, but we need to remember a treatment for a condition is a whole lot 'easier' than a cure. Easier in quotations because a treatment for tinnitus is not easy at all, but it's all relative.
@annV to the rescue. The original journal-provided full article PDF here.
Hey, I just worked out why the TFI was relatively low compared to the decrease in loudness. Feel free to correct, but most people with tinnitus don't consider it greatly affecting their quality of life to begin with. People with severe tinnitus and people like us are in the minority.
@Fightthearmy, in Phase 1 the starting TFI was also quite low. Off the top of my head, 30 ish. So even if it was higher around 50, then a reduction of 15-20 points is a lot.
You do understand that's the case for most trials, this one included. Very hypocritical to acknowledge the suffering of animals from Neuralink, but disregard the countless animals that have been blasted with incredibly loud sounds to give them tinnitus in this scientific study.
I work for a company that test pharmaceuticals on animals. What we don't do, however, is exactly what Neuralink have done and test products on animals that are rushed and absolutely not fit for animal studies yet.
Yes - we have hope. Never before has any tinnitus trial been this successful at such an advanced stage, nor has there been any with such rigorous design and deep pre-trial basic science done. I'm personally very confident this will bring us at least some kind of relief.
Where is this chart from? It is quite incomprehensible. What does active first mean? Control first? Why do columns start at zero? Anyone had zero tinnitus years? Can someone explain in detail what data this chart shows?
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