Nicotinic Acetylcholine Receptors as Therapeutic Tinnitus Targets

[Nick47]

This is a thesis completed by Madan Ghimire at Southern Illinois University.

In a behavioral tinnitus test, both sazetidine-A and varenicline were effective in lowering the tinnitus-like behavior. In conclusion, we identified a significant tinnitus-related disruption in intrinsic physiology of layer 5 PNs and VIP neurons, with strong evidence of dysregulated cholinergic signaling. Partial/desensitizing agonists sazetidine-A and varenicline increased the activity of inhibitory input neurons, showing therapeutic potential in both subcellular and behavioral studies.

→ Impact of Tinnitus in Primary Auditory Cortex in a rat model of tinnitus: nicotinic acetylcholine receptors as possible therapeutic targets

 

[Jonno02]

You're an absolute powerhouse at keeping this community up to date with research news, Nick, some man.

 

[Stayinghopeful]

Newsman Nick coming in hot with the news once again. Good find brother.

 

[lcj]

Chantix (varenicline) is widely available as a smoking cessation drug by prescription. Anyone want to try it and report back?

 

[Nick47]

Chantix (varenicline) is widely available as a smoking cessation drug by prescription. Anyone want to try it and report back?

Just bear in mind this was an animal study.