One of the Largest Tinnitus Trials Yet

[bill 112]

Ya I hear it on the radio non stop I believe we are years away from proper T treatment but hopefully this can be the first step

These treatments are nothing new Cillian,they've been around for some years now and they're nothing spectacular.Yes they're a step towards a proper treatment but it seems we've been stuck on this step for too long now and it's about time we moved on.

 

[Markku]

I'm fairly certain MuteButton was already on sale and available in Ireland last year, with plans to bring it to UK (that part never came to fruition) and maybe other parts of EU.

They were supposed to publish their clinical trial results last year, but I don't think they ever did.

Then the sale was stopped in Ireland.

Last year, NeuroMod (responsible for MuteButton) raised €5.5M, which they announced in September, if my memory serves.

And now another clinical trial occurring. It seems they also plan to do US trial.

http://neuromoddevices.com/newsroom

 

[Cillian]

@Markku are you confident that proper treatment will be available eventually? And are a lot of companies looking into treating T?

Regards Cillian

 

[bill 112]

I'm fairly certain MuteButton was already on sale and available in Ireland last year, with plans to bring it to UK (that part never came to fruition) and maybe other parts of EU.

They were supposed to publish their clinical trial results last year, but I don't think they ever did.

Then the sale was stopped in Ireland.

Last year, NeuroMod (responsible for MuteButton) raised €5.5M, which they announced in September, if my memory serves.

And now another clinical trial occurring. It seems they also plan to do US trial.

http://neuromoddevices.com/newsroom

View attachment 10218

I've read that article in The Irish Times Markku and it after more digging I read about the planned trials etc but nothing ever came of them?And then they pulled out of Ireland and didn't post any results which only confirmed my fears regarding this being a gimmick.But who knows maybe they will pull something off but it's just my hopes aren't high for this.

 

[Jamclem]

@bill 112 yeah defos. Perhaps there is another trial somewhere where you could take part? So you know, I live in St Gallen, Switzerland so that trial in Dublin is too far from me I am afraid

 

[Cillian]

@Jamclem hi I got turned down already so many people are applying here haha

 

[Jamclem]

@Cillian do they not show you the acceptance criteria before you apply?

 

[Cillian]

@Cillian do they not show you the acceptance criteria before you apply?

No if you look up the thread you will see the e mail response just saying I hadn't been accepted

 

[Eltel]

Just started the application process but I failed as not a Resident . If I had hope it had a chance of Success I would have flown there the 5 times required

 

[Vasckin]

One of the world's largest ever clinical trials into tinnitus is to take place in Dublin and people suffering with the condition are being asked to take part. This new trial will take place in St James's Hospital's newly founded Research and Innovation Hub. Its aims is to compare the effects of different settings of an approved medical device on the symptoms of the condition. It is hoped this will lead to better treatment for those affected.

http://www.irishhealth.com/article.html?id=25349

 

[Cillian]

@Vasckin did you apply ? Me and @bill 112 were turned down unfortunately as there are thousands applying

 

[jeff W]

It's all being kept somewhat a secret here for some reason and I can't understand it.Absolutely nobody is aware of Mutebutton and I mean nobody!Ents,specialists you name it have no idea what Mutebutton is.I've emailed them a few times but just got obscure responses back from them.My expectations is extremely low for this.

What is it you want to know? The original (first) trial results were not published, they just release a sheet with some lines of text.

 

[jeff W]

@bill 112 yeah defos. Perhaps there is another trial somewhere where you could take part? So you know, I live in St Gallen, Switzerland so that trial in Dublin is too far from me I am afraid

I wouldn't stop Switzerland for Dublin. just saying.

 

[bill 112]

What is it you want to know? The original (first) trial results were not published, they just release a sheet with some lines of text.

Basic information Jeff,like what the trial entails and what the inclusion/exlusion criteria is,something they seem so far to have failed to do.When anyone here applies for the trial you just get a no without any questions about your history and when you ask them very basic questions about the trial they act like you don't exist.Is that too much to ask.....

 

[Zug]

Well, the Irish gave us great drinks. If they cure Tinnitus, I'll have one more reason to like them

 

[Daveyrvancleef]

I've got an reply. They are 'almost' accepting me in their research. They asked for my name and phone number and I will get a call from them. They want more information and i'm not sure what that is.

 

[IreneO]

@Daveyrvancleef That is interesting - you seem to be the first person on this forum whose application wasn't rejected sight unseen. Do keep us posted. I'm curious as to what selection criteria they're using.

 

[Daveyrvancleef]

@Daveyrvancleef That is interesting - you seem to be the first person on this forum whose application wasn't rejected sight unseen. Do keep us posted. I'm curious as to what selection criteria they're using.

I will come with updates. I asked my sister for financing the trip and she said yes, so that's a win for me. So well see if they call me and hopefully I will give the right answers!

This was their reply on my intake:

Dear Sir or Madam,

Thank you for completing the Eligibility Assessment for our tinnitus trial. You that you have been identified as a potentially eligible participant for the screening process in St James's Hospital. In order to confirm eligibility a member of the team would like to speak to you. Please reply to this email with your name and phone number.

Looking forward to hearing from you.

Kind Regards,

Tinnitus Trial Support Team​

 

[Daveyrvancleef]

UPDATE:

They gave me a call and they asked me a few questions. Questions about my tinnitus, if I got the time to travel 6 times from the Netherlands to Dublin and if I had any epileptic symptoms and/or using 'drugs' for those epileptic symptoms.

He was fairly positive about my answers. My answers will be reviewed by the research team and then I will get an answer if I'm accepted to the trial in Dublin.

 

[Beste]

UPDATE:

They gave me a call and they asked me a few questions. Questions about my tinnitus, if I got the time to travel 6 times from the Netherlands to Dublin and if I had any epileptic symptoms and/or using 'drugs' for those epileptic symptoms.

He was fairly positive about my answers. My answers will be reviewed by the research team and then I will get an answer if I'm accepted to the trial in Dublin.

Hey, happy for you. I hope things will go great for you. And thank you for updating.

But I wonder why they asked things about epilpsy. Since we know epileptic drugs are effective in reducing the severity of tinnitus more or less to many people I wonder if they will work on potassium channels.

 

[Daveyrvancleef]

Hey, happy for you. I hope things will go great for you. And thank you for updating.

But I wonder why they asked things about epilpsy. Since we know epileptic drugs are effective in reducing the
severity of tinnitus more or less to many people I wonder if they will work on potassium channels.

I'm not sure, but maybe they dont want to have participants with epilepsy for their trial? Well see, if there is an update, I'll post it.

 

[Vinnitus]

I don't know where to leave this, as I cannot post in the clinical trials forum. I just wanted to put out that apparently a clinical trial for Tinnitus has started recently in St. James Hospital, Dublin (Ireland). I stumbled upon it today. So for all the Irish folks here, maybe something to try to get into.

http://www.irishtimes.com/life-and-style/health-family/tinnitus-trials-participants-wanted-1.2709851

http://tinnitustrials.ie/

Maybe someone can put this in the "Clinical Trials" section?

EDIT: Ah, seems there was a thread already. Thanks for moving.

 

[Kimbo Slice]

This actually looks like a reasonable theory. Check it out guys. Here's the link to the full article:

http://www.irishtimes.com/life-and-style/health-family/tinnitus-trials-participants-wanted-1.2709851



About 350 patients will take part in the Tinnitus trials, which is expected to last for about three months. Participants will take home the device and use it for an hour a day. The clinical research team will monitor their progress, and they'll return to the hospital for regular assessments over the three-month period.

"We'll be looking at various stimulation patterns, which is the most effective, and how one stimulation pattern compares to the other, and how that influences the loudness and impact of the tinnitus on them. And we'll be following them up in the long term."

Conlon hopes that if he finds the right stimulation pattern, it might help recalibrate the brain so it doesn't perceive the noise. "The ear is picking up sound all the time and feeding it into the brain. Even in complete quietness, the auditory nerve is sending signals in using a million fibres. If something happens to your cochlea, your inner ear, and it gets damaged, those fibres now are no longer sending those signals into the central auditory processing system, which is a complex series of networks that go all the way up to the brain where you understand sound. So when the brain stops getting that feed peripherally, those central auditory processing areas start firing up themselves. They take off on their own. That's what we think happens with tinnitus.

"It's a little bit like phantom pain; somebody loses their hand and then they feel pain in the hand, because they're not getting that peripheral sensory input from the hand because it's no longer there, and so you get neural firing from within that part of your brain that's designed to register your hand." tinnitustrials.ie