P2Y12 Antagonists (Clopidogrel, Ticlopidine, Ticagrelor) for Noxacusis?

I emailed Hyperacusis Research but they won't give me her email.

I'll see if I can squirt some information out of the University of Iowa.

 

Megan Beers Wood's email is:

lwood20@jhmi.edu

This was taken from her CV, which I attached. The email is current and working (she's still at Johns Hopkins).

 

Love it, thank you.

 

On 15 September, roughly 3 months after the CHMP recommendation, Gefapixant (Lyfnua), a P2X3 antagonist, received a marketing authorisation for the European Union.

 

"OHC vesicle exocytosis is triggered by the influx of Ca2+ through class-D L-type Ca2+ channels (CaV1.3) clustered at each active zone."

Calcium signaling in the cochlea – Molecular mechanisms and physiopathological implications

"ATP activates P2X3 receptors in the basolateral membrane of OHCs, leading to OHC depolarization and an increased open probability of voltage-gated CaV1.3 (part of the L-type group) Ca2+ channels."

Coordinated calcium signalling in cochlear sensory and non‐sensory cells refines afferent innervation of outer hair cells

 

Hey, in layman’s terms, what does this mean?

 

Hey, do you want the long answer or the short answer?

 

Hey, let’s go for the short answer, although I’m happy to hear both!