P2Y12 Antagonists (Clopidogrel, Ticlopidine, Ticagrelor) for Noxacusis?

[StoneInFocus]

If you send her an email and hear back, definitely let us know what she says. I want to know if she spit some heat at this conference.

I emailed Hyperacusis Research but they won't give me her email.

I'll see if I can squirt some information out of the University of Iowa.

 

[annV]

I emailed Hyperacusis Research but they won't give me her email.

I'll see if I can squirt some information out of the University of Iowa.

Megan Beers Wood's email is:

lwood20@jhmi.edu

This was taken from her CV, which I attached. The email is current and working (she's still at Johns Hopkins).

 

[StoneInFocus]

Megan Beers Wood's email is:

lwood20@jhmi.edu

This was taken from her CV, which I attached. The email is current and working (she's still at Johns Hopkins).

Love it, thank you.

 

[StoneInFocus]

On 15 September, roughly 3 months after the CHMP recommendation, Gefapixant (Lyfnua), a P2X3 antagonist, received a marketing authorisation for the European Union.

 

[StoneInFocus]

"OHC vesicle exocytosis is triggered by the influx of Ca2+ through class-D L-type Ca2+ channels (CaV1.3) clustered at each active zone."

Calcium signaling in the cochlea – Molecular mechanisms and physiopathological implications

"ATP activates P2X3 receptors in the basolateral membrane of OHCs, leading to OHC depolarization and an increased open probability of voltage-gated CaV1.3 (part of the L-type group) Ca2+ channels."

Coordinated calcium signalling in cochlear sensory and non‐sensory cells refines afferent innervation of outer hair cells

 

[ActorFred]

"OHC vesicle exocytosis is triggered by the influx of Ca2+ through class-D L-type Ca2+ channels (CaV1.3) clustered at each active zone."

Calcium signaling in the cochlea – Molecular mechanisms and physiopathological implications

"ATP activates P2X3 receptors in the basolateral membrane of OHCs, leading to OHC depolarization and an increased open probability of voltage-gated CaV1.3 (part of the L-type group) Ca2+ channels."

Coordinated calcium signalling in cochlear sensory and non‐sensory cells refines afferent innervation of outer hair cells

Hey, in layman's terms, what does this mean?

 

[StoneInFocus]

Hey, in layman's terms, what does this mean?

Hey, do you want the long answer or the short answer?

 

[ActorFred]

Hey, do you want the long answer or the short answer?

Hey, let's go for the short answer, although I'm happy to hear both!