Sensory Hair Cells Regenerated in Mammal Ear

[Nucleo]

One year later, no progress. What on earth happens to these discoveries??

A year is an extremely short time in life science research. Expect the next breakthrough in 5-10 years.

 

[Ecip]

Its quite ridiculous. If even a quarter of the money spent on war and killing people was spent on research, a cure or easy treatment would of probably already been found.
And if only corporations et al would quit being so damn greedy....

 

[JohnK]

Well, war has generated a huge number of people with tinnitus, so there's that...

 

[Ecip]

True. Lots of customers.

 

[Vinnitus]

So, we are almost another year further down the line. What ever came from this drug?

 

[Aaron123]

So, we are almost another year further down the line. What ever came from this drug?

I believe Audion is developing it.

 

[Vinnitus]

I believe Audion is developing it.

Oh yes, you are right. Didn't Audion plan for clinical trials in 2017? That might mean they made some good progress with this compound or one of the "related" compounds mentioned in the quote below...

Luckily, the drug industry had plenty of molecules at the ready. It turns out that many inhibitors of γ-secretase, an enzyme companies long pursued for its role in forming the amyloid deposits that are the hallmark of Alzheimer's disease, also knock out Notch. Using a stem cell screen, Edge landed on a potent γ-secretase inhibitor: Eli Lilly & Co.'s LY411575.

Edge was able to show that giving mice the compound resulted in enough hair cell growth to improve hearing. The discovery is the scientific basis for Audion Therapeutics, a biotech start-up that recently scored a first round of funding from Lilly. Lilly also licensed a series of related compounds to the firm, with an option to buy them back after Phase IIa tests.

http://cen.acs.org/articles/92/i14/Sound-Science.html

 

[Jiri]

So it's 2018. That's 5 years from the firts post and other posts from 2013 on this LY411575 compound that's supposed to regenerate auditory hair cells.

Any progress?? Is it available yet?

 

[dpdx]

So it's 2018. That's 5 years from the firts post and other posts from 2013 on this LY411575 compound that's supposed to regenerate auditory hair cells.

Any progress?? Is it available yet?

You will have to wait quite some time.

 

[Paulmanlike]

So it's 2018. That's 5 years from the firts post and other posts from 2013 on this LY411575 compound that's supposed to regenerate auditory hair cells.

Any progress?? Is it available yet?

No but if you're not up to date

- phase 1 trail completed for frequencys compound. Successful meaning that the drug has potentially reached the cochlear without any serious adverse effects

Phase 2 trial starting soon...

Going to be a good few years yet that's even if it's successful.

 

[Jiri]

No but if you're not up to date

- phase 1 trail completed for frequencys compound. Successful meaning that the drug has potentially reached the cochlear without any serious adverse effects

Phase 2 trial starting soon...

Going to be a good few years yet that's even if it's successful.

Yes, I get it so potentialy another 10 years of waiting IF it is successful. Round and round.

 

[Mricha37]

No but if you're not up to date

- phase 1 trail completed for frequencys compound. Successful meaning that the drug has potentially reached the cochlear without any serious adverse effects

Phase 2 trial starting soon...

Going to be a good few years yet that's even if it's successful.

FDA will fast track this if successful

 

[Coleoptere]

Might be Audion. So see the other thread.

 

[Aaron123]

So it's 2018. That's 5 years from the firts post and other posts from 2013 on this LY411575 compound that's supposed to regenerate auditory hair cells.

Any progress?? Is it available yet?

No it's not available. Five years is quick to about right to get from that point to this point.

This thread started to discuss a paper out of Albert Edge's lab. Since it came out of Edge's lab, my guess is that Audion was initially developing it, but they have since moved to LY3056480. Based on the paper from last February, Frequency is using LY411575.

Given there are threads on Audion's trial and on Frequency, this thread doesn't seem very useful at this point.