I experienced an increase of T when my Zoloft dosage was increased. It bothered me so much that I asked to try Effexor instead. I had been on a low dose of Zoloft for years and it had never bothered me much and I had never associated it with T before. Effexor seemed to not bother my T except in the very beginning and may have even helped it but the other side effects I couldn't handle. It gave me insomnia, sweats, I was hungry as a bear and gained weight quickly, constipated, helped with anxiety but still felt depressed. I have decided to give Zoloft another try and I'm really, really counting on Beth being right about this!