Sound Pharmaceuticals (SPI-5557 & SPI-1005)

[Scruffiey]

I feel that the fact that tinnitus has been reversed in mice means it could potentially be reversed in humans. While that doesn't necessarily mean Ebselen will have the same effect in people, it's still a significant development.

Anecdotal, of course, but I came across someone on Reddit who claimed to have participated in the Ménière's trial. While they were pleased with the reduction in vertigo, they unfortunately said it had done nothing for their tinnitus. So, for now, this is just a small step forward.



I have my suspicions that this drug might be useful to some degree for some of us, as it clearly reaches the right areas. I'm really, really hoping it helps with TTTS, hyperacusis, and noxacusis—maybe even with reducing early-onset tinnitus levels or something similar.

I believe tinnitus will be treatable, if not curable, within the next 15 years. And yes, Ebselen may be the starting gun. If they could develop the equivalent of paracetamol for a bad headache—something that could smooth out the pitch and level on difficult days—that would be incredible. The mental health benefits and overall improvement in quality of life, just from knowing there was even the slightest safety net, would be unprecedented.

 

[LovableGamer]

Can anyone tell me the current status of SPI-5557? This is for hearing loss, right? Is SPI-1005 also for hearing loss, or is it for something else?

I have hearing loss, and with all the different research happening, it gives me hope that one day I might be able to hear like a normal person. If that happens, maybe my tinnitus will decrease or even stop altogether since the nerves would be functioning properly.

 

[Scruffiey]

I found another Reddit post from someone in the trials (it seems there was no NDA). They felt there was some benefit to their tinnitus levels throughout the day while taking it, unlike the person I mentioned earlier. For what it's worth, their experience seemed more positive.

Can anyone tell me the current status of SPI-5557? This is for hearing loss, right? Is SPI-1005 also for hearing loss, or is it for something else?

I have hearing loss, and with all the different research happening, it gives me hope that one day I might be able to hear like a normal person. If that happens, maybe my tinnitus will decrease or even stop altogether since the nerves would be functioning properly.

SPI-1005 is currently indicated only for Meniere's disease to reduce vertigo attacks, slow hearing loss, and reduce tinnitus. There is some hope that it might have benefits off-label or after further investigation, but there are no guarantees.

You've mentioned Turner syndrome in your other posts. SPI-1005 almost certainly won't reverse any hearing loss you've already experienced, but there is a chance it might help prevent further progression depending on the underlying pathology. It is also being tested for the prevention of acute noise-induced hearing loss, and since it works for Meniere's disease as well, that suggests a possible protective effect.

As for SPI-5557, there has been no public progress as far as I'm aware. I believe the focus has been on bringing SPI-1005 to market.

I do think advancements will continue, and your hearing may eventually be restorable, but it could be a while before such treatments become available—likely not until 2035 or later. Hopefully, at least a tinnitus treatment will arrive much sooner.

 

[LovableGamer]

I found another Reddit post from someone in the trials (it seems there was no NDA). They felt there was some benefit to their tinnitus levels throughout the day while taking it, unlike the person I mentioned earlier. For what it's worth, their experience seemed more positive.

SPI-1005 is currently indicated only for Meniere's disease to reduce vertigo attacks, slow hearing loss, and reduce tinnitus. There is some hope that it might have benefits off-label or after further investigation, but there are no guarantees.

You've mentioned Turner syndrome in your other posts. SPI-1005 almost certainly won't reverse any hearing loss you've already experienced, but there is a chance it might help prevent further progression depending on the underlying pathology. It is also being tested for the prevention of acute noise-induced hearing loss, and since it works for Meniere's disease as well, that suggests a possible protective effect.

As for SPI-5557, there has been no public progress as far as I'm aware. I believe the focus has been on bringing SPI-1005 to market.

I do think advancements will continue, and your hearing may eventually be restorable, but it could be a while before such treatments become available—likely not until 2035 or later. Hopefully, at least a tinnitus treatment will arrive much sooner.

Thank you! It would definitely be great if it could at least help protect my hearing from getting worse.

 

[Fightthearmy]

I believe tinnitus will be treatable, if not curable, within the next 15 years. And yes, Ebselen may be the starting gun. If they could develop the equivalent of paracetamol for a bad headache—something that could smooth out the pitch and level on difficult days—that would be incredible. The mental health benefits and overall improvement in quality of life, just from knowing there was even the slightest safety net, would be unprecedented.

Could, would, may, hoping that… Looking at where my career and life will be in 15 years.