Did an acoustic trauma cause your tinnitus?Do you think tinnitus caused by Meniere's disease differs from other tinnitus? One ENT said off-hand that he thought I had endolymphatic hydrops, which is apparently the same thing. I've kinda had high hopes for SPI-1005 but I don't have much use for something "otoprotective" when my hearing is already buggered.
I'm very surprised. CHRONIC tinnitus?They will test SPI-1005 for tinnitus next year.
So, I take it the drug was successful in the clinical trial. It would be great if this drug worked on non-Meniere's tinnitus sufferers, too.
Why do you think that? If it works for Meniere's disease-related tinnitus, it could work for garden-variety tinnitus, too.I'm very surprised. CHRONIC tinnitus?
I see no indication as to how SPI-1005, a systemic anti-inflammatory, could be beneficial for tinnitus.
Isn't the new compound Ebselen supposed to target neuroinflammation? If it proves successful for Meniere's disease, why wouldn't it work for us?I'm very surprised. CHRONIC tinnitus?
I see no indication as to how SPI-1005, a systemic anti-inflammatory, could be beneficial for tinnitus.
In Meniere's, there is usually inflammation in the cochlea due to the hydrops that cause its membranes to expand and then break, etc. That causes irreversible damage that stays even when the inflammation goes away.Isn't the new compound Ebselen supposed to target neuroinflammation? If it proves successful for Meniere's disease, why wouldn't it work for us?
That's interesting. Mine does so too.My tinnitus reduces for the period when I have a sore throat or head cold, so...
My tinnitus reduces for the period when I have a sore throat or head cold, so...
Wish I could say the same. Whenever I get sick or just really stuffy, mine goes haywire. Getting severely sick is what actually gave me a permanent worsening last year.That's interesting. Mine does so too.
This feels like a good first target for Tinnitus Quest to fund a tinnitus trial on SPI-1005, especially if it has gotten this far, and they seem to be already somewhat well-funded and well-established.I reached out to Sound Pharmaceuticals. They said they think SPI-1005 could help noise-induced and ototoxicity-induced tinnitus.
Here's fingers crossed!
Yes, of course, I can forward the email if that helps the founders. I was pretty surprised to get a response, to be honest, but maybe the company is open to discussing their work, and a Tinnitus Talk Podcast episode could be on the cards — and valuable.
Tinnitus Quest has not raised any funds yet, so any money raised needs to be spent wisely and carefully. Allocating funds to the right initiatives at the right time can be the difference between a successful treatment and a failed trial. We've all made mistakes in the past and will undoubtedly make them again in the future. But in theory, do you believe there is enough evidence and rationale to justify funding such a trial?This feels like a good first target for Tinnitus Quest to fund a tinnitus trial on SPI-1005, especially if it has gotten this far, and they seem to be already somewhat well-funded and well-established.
In theory, it could be prescribed for Meniere's disease. However, if the formulation they plan to use for noise-induced or other types of tinnitus is the same as for Meniere's, we could potentially find a willing doctor to try it ourselves. I'm just considering how someone might avoid the long wait for another trial to conclude.FWIW, I did what I do for my job and got into his LinkedIn comments for more detail on what @Tim Dziwisch asked
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I experience the same.Whenever I get sick or just really stuffy, mine goes haywire. Getting severely sick is what actually gave me a permanent worsening last year.
That is great news! Thank you!FWIW, I did what I do for my job and got into his LinkedIn comments for more detail on what @Tim Dziwisch asked
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It will be available in 2 years.I'm just considering how someone might avoid the long wait for another trial to conclude.
Is this your personal estimate, or do you have some information from a good source?It will be available in 2 years.
With all respect, personally, and even though your opinion might be rational, I think we should stop spreading negativity on Tinnitus Talk.Personally, I believe that for chronic tinnitus, the evidence supporting this treatment is weak. At its core, the drug is an antioxidant and anti-inflammatory.
Obviously the drug sponsor wants this to work for noise-induced tinnitus. Apparently they claim it showed some efficacy in animal models.Personally, and even though your opinion might be rational, I think we should stop spreading negativity on Tinnitus Talk.
Even the sponsor of this drug (if I understood it correctly) said that it might help noise-induced tinnitus. So maybe it will work for chronic noise-induced tinnitus as well; we don't know. Let us hope.
Most of us here have lost our lives because of this damn disease. We need HOPE for our mental health.