Hi, stumbled upon this new theory I had never heard of before and just wanted to share. Slightly related to myself as I've had gastrointestinal problem/GERD for years before I had tinnitus and wonder if there's actually a link?
IBD patients release a chemical called substance P – an inflammatory molecule.
Substance P has been linked to inner ear problems, including the auditory irritation called tinnitus, and a history of disease in the gut and an established stress response can lead to a programming of the inner ear and manifest via activation of the delicate nerves as the sounds described as tinnitus.
Evidence suggests that capsaicin-sensitive substance P (SP)-containing trigeminal ganglion neurons innervate the spiral modiolar artery (SMA), radiating arterioles, and the stria vascularis of the cochlea. Antidromic electrical or chemical stimulation of trigeminal sensory nerves results in neurogenic plasma extravasation in inner ear tissues. The primary aim of this study was to reveal the possible morphological basis of cochlear vascular changes mediated by capsaicin-sensitive sensory nerves. Therefore, the distribution of SP and capsaicin receptor (transient receptor potential vanilloid type 1-TRPV1) was investigated by double immunolabeling to demonstrate the anatomical relationships between the cochlear and vertebro-basilar blood vessels and the trigeminal sensory fiber system.
Extensive TRPV1 and SP expression and co-localization were observed in axons within the adventitial layer of the basilar artery, the anterior inferior cerebellar artery, the SMA, and the radiating arterioles of the cochlea. There appears to be a functional relationship between the trigeminal ganglion and the cochlear blood vessels since electrical stimulation of the trigeminal ganglion induced significant plasma extravasation from the SMA and the radiating arterioles.
The findings suggest that stimulation of paravascular afferent nerves may result in permeability changes in the basilar and cochlear vascular bed and may contribute to the mechanisms of vertebro-basilar type of headache through the release of SP and stimulation of TPVR1, respectively. We propose that vertigo, tinnitus, and hearing deficits associated with migraine may arise from perturbations of capsaicin-sensitive trigeminal sensory ganglion neurons projecting to the cochlea.
Taken from below url,
http://www.nleducation.co.uk/resour...ics-can-shift-mood-by-modulating-cytokines/#z
IBD patients release a chemical called substance P – an inflammatory molecule.
Substance P has been linked to inner ear problems, including the auditory irritation called tinnitus, and a history of disease in the gut and an established stress response can lead to a programming of the inner ear and manifest via activation of the delicate nerves as the sounds described as tinnitus.
Evidence suggests that capsaicin-sensitive substance P (SP)-containing trigeminal ganglion neurons innervate the spiral modiolar artery (SMA), radiating arterioles, and the stria vascularis of the cochlea. Antidromic electrical or chemical stimulation of trigeminal sensory nerves results in neurogenic plasma extravasation in inner ear tissues. The primary aim of this study was to reveal the possible morphological basis of cochlear vascular changes mediated by capsaicin-sensitive sensory nerves. Therefore, the distribution of SP and capsaicin receptor (transient receptor potential vanilloid type 1-TRPV1) was investigated by double immunolabeling to demonstrate the anatomical relationships between the cochlear and vertebro-basilar blood vessels and the trigeminal sensory fiber system.
Extensive TRPV1 and SP expression and co-localization were observed in axons within the adventitial layer of the basilar artery, the anterior inferior cerebellar artery, the SMA, and the radiating arterioles of the cochlea. There appears to be a functional relationship between the trigeminal ganglion and the cochlear blood vessels since electrical stimulation of the trigeminal ganglion induced significant plasma extravasation from the SMA and the radiating arterioles.
The findings suggest that stimulation of paravascular afferent nerves may result in permeability changes in the basilar and cochlear vascular bed and may contribute to the mechanisms of vertebro-basilar type of headache through the release of SP and stimulation of TPVR1, respectively. We propose that vertigo, tinnitus, and hearing deficits associated with migraine may arise from perturbations of capsaicin-sensitive trigeminal sensory ganglion neurons projecting to the cochlea.
Taken from below url,
http://www.nleducation.co.uk/resour...ics-can-shift-mood-by-modulating-cytokines/#z
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feeling that my tinnitus is realted to my intestines and maybe candida ... so i`m gonna do a 3 months juice fast starting with frutis and ending with only vegetables ... after that I hope to live on green tea and rice for a long period of time (maybe another 3 months) ... this will clear up alot of inflamation and balance out the acid - base state of the body .. hopefully resulting in some kind of change of T awareness!
