Suppressive Effects of Goshajinkigan on Tinnitus

[InNeedOfHelp]

Behavioral and Immunohistochemical Evidence for Suppressive Effects of Goshajinkigan on Salicylate-Induced Tinnitus in Rats

Abstract
Many people are affected by tinnitus, a sensation of ringing in the ear despite the absence of external sound. Goshajinkigan (GJG) is one of the formulations of Japanese traditional herbal medicine and is prescribed for the palliative treatment of patients with tinnitus. Although GJG is clinically effective in these patients, its behavioral effects and the underlying neuroanatomical substrate have not been modeled in animals. We modeled tinnitus using salicylate-treated rats, demonstrated the effectiveness of GJG on tinnitus, and examined the underlying neuronal substrate with c-Fos expression. Intraperitoneal injection of sodium salicylate (400 mg/kg) into rats for three consecutive days significantly increased false positive scores, which were used to assess tinnitus behavior. When GJG was orally administered one hour after each salicylate injection, the increase in tinnitus behavior was suppressed. The analysis of c-Fos expression in auditory-related brain areas revealed that GJG significantly reduced the salicylate-induced increase in the number of c-Fos-expressing cells in the auditory cortices, inferior colliculus, and dorsal cochlear nucleus. These results suggest a suppressive effect of GJG on salicylate-induced tinnitus in animal models.​

There is also statistically significant evidence that this herb reduces neurotoxicity, neuropathic pains, and now tinnitus suppression in an animal model.

Here is another study that shows that Go-sha-jinki-gan alleviates inflammation by blocking TNF-a in the CNS. Seems to be in line with other research that blocking TNF-a helps with tinnitus.

Go-sha-jinki-Gan Alleviates Inflammation in Neurological Disorders via p38-TNF Signaling in the Central Nervous System

Anyone with experience with this supplement? I guess it it is sold under a Western name too?

 

[Hottopic29]

I'm game, this looks like a natural diuretic too.

 

[Uklawyer]

Imagine if this helped 40-50% of sufferers...

 

[DebInAustralia]

Where can we source it?

 

[AfroSnowman]

Where can we source it?

Looks like it is available on Amazon and other online sites. It is sold as a bladder control supplement.

 

[Hottopic29]

It's like a loop diuretic. Maybe it regulates the ear fluids and inflammation too. Seems like worth a shot to me. I did want to try diuretics.

Bladder Regulator, Gosha Jinki Gan An Effective Herbal Bladder Control Support Formula

 

[KoolKat]

Looks like it is available on Amazon and other online sites. It is sold as a bladder control supplement.

I would love if professionals tested this but apparently it takes 100 years just to start preclinical trials and another 5000 years to get to Phase 3 only for them to run out of funds or get deemed a failure.

I guess we have to try it out ourselves.

I can't believe they are only NOW testing this out. Are researchers really just now catching up with tinnitus?

 

[El BUZZ]

Will try it as soon as possible.

My friends and relatives are always telling me I'm a rat so this should work for me!

 

[LostinTX]

But this is for salicylate-induced tinnitus which in most people is usually reversed by cutting out salicylate rich foods and they improve within a few months just cutting that out. I still wouldn't knock trying it. But, I'd be more apt to find a potassium channel drug that works like Retigabine did, but safer.

 

[Hottopic29]

But this is for salicylate-induced tinnitus which in most people is usually reversed by cutting out salicylate rich foods and they improve within a few months just cutting that out. I still wouldn't knock trying it. But, I'd be more apt to find a potassium channel drug that works like Retigabine did, but safer.

Yes it also has a huge anti-inflammatory effect so may help. It's not a pharmaceutical at least.

 

[ibd]

Since I'm also suffering from peripheral neuropathy and another inflammatory rheumatic disease, trying this out seems ideal for me.

Do we know from the links that @InNeedOfHelp posted, or otherwise, what would be an appropriate dosage for humans? The application of a drug for bladder control might have a different effective dosage than for tinnitus.

EDIT:

OK, I've since checked these publications. The first one used 1g GJG / kg body weight, which would definitely be too much when scaled up to human levels. The second one reads:

"The standard daily dose of GJG prescribed for human use is 7.5 g, which contains 4.5 g of spraydried mixed extract."

 

[InNeedOfHelp]

But this is for salicylate-induced tinnitus which in most people is usually reversed by cutting out salicylate rich foods and they improve within a few months just cutting that out. I still wouldn't knock trying it. But, I'd be more apt to find a potassium channel drug that works like Retigabine did, but safer.

It being tested on a salicylate-induced tinnitus animal model, and giving suppressed tinnitus effects shortly after, does not mean that this is meant for salicylate-induced tinnitus. This is part of the standard tinnitus protocol in Japan as 'palliative' care. This study actually confirms the mechanism of action.

The medical word of southeast Asia and western countries are split miles apart.

The difficulty, as always with tinnitus, is, for which subgroup does it work and for which one doesn't?

I'm going to give it a go, nothing to lose.

If you buy this, make sure the ingredient list is equal to the original Japanese one. I already see plenty of bladder supplements if you Google these extracts. The ingredient list does not match the original Japanese one.

https://bio-japan.net/tsumura-goshajinkigan-granules

 

[Jerad]

Anyone going to try this?

 

[GlennS]

apparently it takes 100 years just to start preclinical trials and another 5000 years to get to Phase 3 only for them to run out of funds or get deemed a failure.

LOL. Another treatment I know, but when reading this I suddenly have images of Susan Shore's head in a Futurama glass jar.

 

[Hottopic29]

From Google:

For both salicylate- and noise-induced tinnitus, aberrant N-methyl-d-aspartate (NMDA) receptor activation and related auditory nerve excitation have been suggested as origin of cochlear tinnitus. Accordingly, NMDA receptor inhibition has been proposed as a pharmacologic approach for treatment of synaptopathic tinnitus.​

So this may work for my noise-induced tinnitus.

 

[Jerad]

It being tested on a salicylate-induced tinnitus animal model, and giving suppressed tinnitus effects shortly after, does not mean that this is meant for salicylate-induced tinnitus. This is part of the standard tinnitus protocol in Japan as 'palliative' care. This study actually confirms the mechanism of action.

The medical word of southeast Asia and western countries are split miles apart.

The difficulty, as always with tinnitus, is, for which subgroup does it work and for which one doesn't?

I'm going to give it a go, nothing to lose.

If you buy this, make sure the ingredient list is equal to the original Japanese one. I already see plenty of bladder supplements if you Google these extracts. The ingredient list does not match the original Japanese one.

Is your link for one that does match the ingredients properly? I found one here:

Bladder Regulator, Gosha Jinki Gan An Effective Herbal Bladder Control Support Formula

Would this one work?

 

[InNeedOfHelp]

Is your link for one that does match the ingredients properly? I found one here:

Bladder Regulator, Gosha Jinki Gan An Effective Herbal Bladder Control Support Formula

Would this one work?

I don't see an ingredient list in the study. But I would trust the product made for Japanese domestic market more, assuming it is a standard medicine there. I think their product would be quite generic, no matter which brand. Amazon shopping would be tricky I'd say especially if there are no proper ingredient lists.

 

[Joeseph Stope]

LOL. Another treatment I know, but when reading this I suddenly have images of Susan Shore's head in a Futurama glass jar.

Well, I understand where you're coming from and your impatience is understandable but that's 50% => 70% of what it's all about. You know, tinnitus spikes, good days, bad days etc. and then when you try some new medicine or treatment, your tinnitus goes up or goes down, it's also dependent on mood or general health.

So the hope is the @DebInAustralia's team (the Bionics Institute) can come along with their objective measure of tinnitus and provide some objective clarity.

Failing that maybe they find some way of measuring the number of active hair cells -- inner or outer hair cells or the synapses.

Suffice to say, there's no harm in trying or in searching for new treatments... the proviso being that they shouldn't do actual harm.

 

[Hottopic29]

Anyone try this yet?

 

[ibd]

I have a shipment for 1.5 months worth of tablets underway from Japan. I couldn't find another reliable source for getting it in Switzerland.

I ordered this one via Zenmarket: https://item.rakuten.co.jp/drugpure/4987045048906-3/

 

[Travis Henry]

I have a shipment for 1.5 months worth of tablets underway from Japan. I couldn't find another reliable source for getting it in Switzerland.

I ordered this one via Zenmarket: https://item.rakuten.co.jp/drugpure/4987045048906-3/

How did you order it? I can't since I only know English.

 

[ibd]

How did you order it? I can't since I only know English.

I don't speak Japanese either. As I wrote, I used Zenmarket to order it for me, and forward the order to me. This is the direct link:

https://zenmarket.jp/rakutenproduct.aspx?itemCode=drugpure:10005348

 

[Joeseph Stope]

Will try it as soon as possible.

My friends and relatives are always telling me I'm a rat so this should work for me!

Who knows, maybe there is one magic herb out there. We just have to go through them all till we find it.

Oh... and it matters whether the tinnitus is chronic or acute.

 

[JPGL]

It would be incredible if there was a herb that cured tinnitus.

 

[BuzzyBee]

You could just try pumpkin seed oil. Now Foods brand is pretty good. It's a diuretic and supposedly anti-inflammatory. And if it doesn't calm your tinnitus, it will at least make your hair grow Seriously, though. Read the reviews on how it works as a diuretic. It seems to have the same properties as the Japanese herb.

 

[Nick47]

Mine is not salicylate induced and I'm not a rat!

 

[kestokas]

Hello,

I've just got my package from Japan. I'm going to try this from tomorrow. Maybe someone can help me with translation for back of the package of this extract.

 

[InNeedOfHelp]

Maybe someone can help me with translation for back of the package of this extract.

Crappy Google translate but:

Dosage and administration-Usually, 7.5 g of adult daily is divided into 2 to 3 times and orally administered before or between meals. The dose may be adjusted according to the patient's age, body weight and symptoms. ) 13.0g Nikkei Sanyaku ・ ・ ・ ・ ・ ・ ・ ・ 13.0g Shazenshi ........... 3.0g Nikkei Takusha ..... -3.0 € 0 5.0g 3.0g 1973 This product 7.5g It contains 4.5 g of mixed raw dry extract in the following proportions. Cinnamon Jio, Cinnamon Bukuryo, Goshitsu Buttonpi ... Cinnamon Sanshuyu ...... -3.0g F9 I F104) Medical) [3 packets x 7 sheets x 2 east (105g)] PANCRE * Zai 3.0g 3.Dg 1.0g 1.0g Contents: 2.5g x 42 packets (LOD BEK slope description F12 backspace Tsumura 7-11 insert scroll t delete home 1944 end page up A page num lock PREUNA loglach 7 I 8 19

 

[Hottopic29]

I've just got my package from Japan. I'm going to try this from tomorrow. Maybe someone can help me with translation for back of the package of this extract.

I'm guessing no results?

 

[JFR]

Just received my package. Will start taking it 3 times a day and see what happens.