The 'Love Hormone' (Oxytocin) May Quiet Tinnitus

[lapidus]

Oxytocin Nasal Spray 10 UI - Super-Nutrition

I wouldn't trust that one. I'm 99% sure it's just tap water like everything on amazon etc that claims to be oxytocin nasal spray for two reasons:
1. It's sold from a site called "super-nutrition" which rings a warning and indicates that they do not sell stuff that can be considered actual medication but rather nutritional supplements.
2. The producer behind that brand of oxytocin is called "Smart Publications" and from my brief research they seem to be a alternative/nature medicine web publication that mostly promotes nutritional supplements.

I call homeopathic bullshit. Contact a doctor instead.

EDIT: Oh, and I forgot.
3. "Do not take if you are pregnant or breast-feeding" Well, the main use for oxytocin is to prescribe it to new mothers who are breast-feeding, so that doesn't really add up, does it?

 

[Anima]

Thank you very much to you all for your comments and advice.

You are quite right, it's better not to run any risk with this stuff till more research is done and never trust certain places online mainly when it comes to medication.

Best regards.

 

[HomeoHebbian]

Hey oxytocin fans, I'm chiming into this thread a bit late, with apologies if these points have already been raised.

Oxytocin is a peptide that can be introduced exogenously (from outside your body) but there is a lot of debate as to whether and how it is able to cross the blood-brain barrier when inhaled with nasal sprays. Oxytocin is also synthesized endogenously (from inside your body) by an evolutionarily ancient nucleus in your brainstem called the hypothalamus. The nerve cells that naturally create oxytocin release this chemical during activities associated with intense pair bonding. For example, during orgasm and breastfeeding.

There was a beautiful study published a few years back in the most prestigious science journal in the land about the actions of oxytocin release in the auditory cortex of mice. When new mothers are listening to the pathetic sounds of their infant pups cries it turns on their oxytocin centers and changes the physiology of their auditory cortex in a long-lasting way.

This plasticity is achieved by changing the recuitment of GABAergic inhibitory "silencing" neurons. Is this ringing any bells (haha) for people here in the context of tinnitus? Most scientists think that dysregulation of these GABA neurons in the auditory processing centers of the brain is a essential factor (maybe THE essential factor) that creates the perception of the phantom sound.

http://www.nature.com/nature/journal/v520/n7548/full/nature14402.html

 

[lapidus]

Hey oxytocin fans, I'm chiming into this thread a bit late, with apologies if these points have already been raised.

Oxytocin is a peptide that can be introduced exogenously (from outside your body) but there is a lot of debate as to whether and how it is able to cross the blood-brain barrier when inhaled with nasal sprays. Oxytocin is also synthesized endogenously (from inside your body) by an evolutionarily ancient nucleus in your brainstem called the hypothalamus. The nerve cells that naturally create oxytocin release this chemical during activities associated with intense pair bonding. For example, during orgasm and breastfeeding.

There was a beautiful study published a few years back in the most prestigious science journal in the land about the actions of oxytocin release in the auditory cortex of mice. When new mothers are listening to the pathetic sounds of their infant pups cries it turns on their oxytocin centers and changes the physiology of their auditory cortex in a long-lasting way.

This plasticity is achieved by changing the recuitment of GABAergic inhibitory "silencing" neurons. Is this ringing any bells (haha) for people here in the context of tinnitus? Most scientists think that dysregulation of these GABA neurons in the auditory processing centers of the brain is a essential factor (maybe THE essential factor) that creates the perception of the phantom sound.

http://www.nature.com/nature/journal/v520/n7548/full/nature14402.html

You aren't late. In fact, you were one of the first posters in this thread and you posted that mouse study back then too

 

[Fabrikat]

The nerve cells that naturally create oxytocin release this chemical during activities associated with intense pair bonding. For example, during orgasm and breastfeeding.

Then one could expect tinnitus to diminish in humans during these activities. Even slightly. But it doesn't.

 

[linearb]

Then one could expect tinnitus to diminish in humans during these activities. Even slightly. But it doesn't.

My tinnitus was at a ~5 year low for the first month that my new baby was in the house with us and I was getting lots of skin-to-skin contact which is known to release these hormones. Of course, I was also off work for a month which meant less stress and less postural tension on my neck/shoulders/jaw, so it's a little hard to say.

I've experimented with an oxytocin nasal spray furnished by a somewhat shady Asian company that sells it for Autism control; if it is indeed oxytocin, consuming it in this way does not have any significant effect on my tinnitus, or on my overall psychological state. It makes me feel a little warm and flushed for a few minutes, and makes my sinuses burn slightly, and that's about it.

 

[HomeoHebbian]

You aren't late. In fact, you were one of the first posters in this thread and you posted that mouse study back then too

Haha. Oh wow, that is embarrassing. My poor, porous memory...

 

[IvanRus]

In my opinion this is nonsense.
Does oxytocin reduce tinnitus?
In my opinion, oxytocin gives exactly the opposite effect - it increases tinnitus.
Every time I fall in love with a woman, tinnitus and anxiety intensifies.
It's terrible - now I even have to avoid such a beautiful feeling as love.
Tell me, maybe someone else?

 

[Silvio Sabo]

In my opinion this is nonsense.
Does oxytocin reduce tinnitus?
In my opinion, oxytocin gives exactly the opposite effect - it increases tinnitus.
Every time I fall in love with a woman, tinnitus and anxiety intensifies.
It's terrible - now I even have to avoid such a beautiful feeling as love.
Tell me, maybe someone else?

You said it your self. "Every time I fall in love with a woman, tinnitus and anxiety intensifies." That would be because of the anxiety and not increase of Oxytocin. Increasing levels of Oxytocin WITHOUT the anxiety is a different thing and could perhaps lower tinnitus.

 

[IvanRus]

Indeed, an experimental study of oxytocin for nasal administration as a tinnitus therapy was conducted.

The result showed a significant decrease in the noise after applying oxytocin as a nasal spray.

https://www.ncbi.nlm.nih.gov/pubmed/28983279?log$=activity

The question is why did not anyone commercialize this treatment, and did not even bring it into clinical practice?

Apparently, because no one cares about tinnitus, everyone only spits on it.

This once again highlights the importance of the work of volunteers, community workers and all of us on Tinnitus Talk in uncovering the problem and communicating with the authorities and researchers about the need for speedy treatment of this condition.

 

[Silvio Sabo]

Indeed, an experimental study of oxytocin for nasal administration as a tinnitus therapy was conducted.

The result showed a significant decrease in the noise after applying oxytocin as a nasal spray.

https://www.ncbi.nlm.nih.gov/pubmed/28983279?log$=activity

The question is why did not anyone commercialize this treatment, and did not even bring it into clinical practice?

Apparently, because no one cares about tinnitus, everyone only spits on it.

This once again highlights the importance of the work of volunteers, community workers and all of us on Tinnitus Talk in uncovering the problem and communicating with the authorities and researchers about the need for speedy treatment of this condition.

I'm pretty sure they are doing further investigations. The paper is about 1 year old. If it had been 10 years old it would have been a different story.

 

[WaqasVic]

Where is @undecided and his cat when required. His cat would be a perfect candidate for such a trial

Couldn't agree more.

 

[Don Tinny]

Try convincing a doctor to prescribe that hormone to reduce T. Its almost impossible

 

[EDDTEKK]

In a German discussion board somebody claimed that after taking this nasal drug her tinnitus disappeared for some time. How can we get this oxytocin nasal drug?
University of Regensburg proposed her to take max 7 puffs in each nose per day.
I am willing to test this but don't know how to get it in Germany

 

[AliceW]

I tried oxytocin nasal spray several days (I bought it on a secure internet website, I live in France) and later, when I delivered my baby, Doctors injected me a very high dose of oxytocin hormone... but it had absolutely no effect on my tinnitus !!!

 

[EDDTEKK]

Hi Alice
Thank you for your feedback. It seems that for some people there is an effect while for others not. Who knows why...
I will ask my psychiatrist if he knows some way to buy it or get prescribed.

 

[GlennS]

The best way to deliver this treatment is the natural method, by having a significant other.

I put into my introductory bio that through convergent evolution I stumbled on various coping strategies. It's almost like my body knew what sorts of activities took the edge off and I naturally started doing it more (or at least wanted to do it more) to the point of addiction. Honeymoon hotel-grade marathon makeouts and sex is the way to go, and worthy of its own thread. Of course, the trick is you need to have a willing participant. I know Sting has T and is notorious for being into tantric sex. For all we know that's why he's into it.

 

[Flamingo1]

There's a better chance of Frequency Therapeutics restoring hearing than there is of me finding love. I'm placing my bet on Fx!

 

[ChrisBoyMonkey]

NYU is starting a clinical trial using oxytocin nasal spray to treat tinnitus.

https://clinicaltrials.gov/ct2/show...itus&phase=012345&lupd_s=12/14/2019&lupd_d=14

 

[Thuan]

I've accidentally stumbled upon this on the ClinicalTrials.gov website.

On PubMed, there was a pilot study, which found out that Oxytocin nasal spray reduced Tinnitus Functional Index by ~20 points in 10 subjects. Link is here.

There's an ongoing clinical study pilot by NYU Langone Health medical center investigating a high dosage Oxytocin nasal spray with 30 participants. The study ends in January, 2021. Link is here.

This is more interesting if it can provide some temporary tinnitus relief for all of us who will be waiting for years for other popular treatments/research on tinnitus and regenerative hearing.

However, as with other hormonal drugs, there are side effects, which might make Oxytocin unsuitable to take for the long term but on the short term, for the really bad tinnitus days, it appears really attractive.

I haven't don't any extensive research except a search on Tinnitus Talk yields only two threads with nonsensical jokes about the "love hormone" which is not helpful.

 

[Kendra]

I've thought about asking my doctor for oxytocin spray. Not sure they would prescribe it though.

 

[Mentos]

I've thought about asking my doctor for oxytocin spray. Not sure they would prescribe it though.

I think it's available online with no prescription.

 

[ajc]

I think it's available online with no prescription.

Oxytocin nasal sprays online are a scam. Ineffective.

Oxytocin needs to be refrigerated, and you won't find online shops that deliver it refrigerated (too expensive a shipping method).

It degrades very quickly without refrigeration.

 

[Capstan]

I had an osteopath prescribe Oxytocin for me. Local compounding pharmacy delivered it on ice. I had the low dosage from the PubMed, not the high dose that NYU is doing.

It did nothing for me. It didn't even do anything as a love hormone... It wasn't worth the effort trying to get the legit product.

What @ajc says is accurate -- stay away from buying it online.

 

[Isabella 123]

Clinical trial on Oxytocin as tinnitus treatment, in NY state:

https://clinicaltrials.gov/ct2/show/NCT04210310

 

[tommyd87]

I wouldn't trust that one. I'm 99% sure it's just tap water like everything on amazon etc that claims to be oxytocin nasal spray for two reasons:
1. It's sold from a site called "super-nutrition" which rings a warning and indicates that they do not sell stuff that can be considered actual medication but rather nutritional supplements.
2. The producer behind that brand of oxytocin is called "Smart Publications" and from my brief research they seem to be a alternative/nature medicine web publication that mostly promotes nutritional supplements.

I call homeopathic bullshit. Contact a doctor instead.

EDIT: Oh, and I forgot.
3. "Do not take if you are pregnant or breast-feeding" Well, the main use for oxytocin is to prescribe it to new mothers who are breast-feeding, so that doesn't really add up, does it?

I predict that this would probably be about as effective as the placebo in the clinical trial about to get started.

 

[Isabella 123]

I'm not familiar with the brands but I am a retired postpartum doula and the Rx kind of oxytocin was very effective for the new mothers who used it to increase their milk supply. Maybe it depends on the brand of oxytocin spray that's used? I certainly don't think what Amazon sells would be worth anything. What I used with new mothers was a Rx.

 

[Mentos]

They plan further studies in the United States:

Nasal spray of 'love hormone' oxytocin could banish ringing in the ears - which affects around seven million Britons

 

[DebInAustralia]

They plan further studies in the United States:

Nasal spray of 'love hormone' oxytocin could banish ringing in the ears - which affects around seven million Britons

When?

 

[Mentos]

When?

Now, in a new trial at New York University, 30 patients will be given either oxytocin nasal spray or a placebo to use four times daily for six months. The results are expected by June next year.