Okay, so here is my theory. Benzo withdrawal can cause excitotoxicity upon withdrawal. According to Wikipedia https://en.wikipedia.org/wiki/Excitotoxicity
"Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances. This occurs when receptors for the excitatory neurotransmitter glutamate (glutamate receptors) such as the NMDA receptor and AMPA receptor are overactivated by glutamatergic storm." Now later in the article it says this:
"Excitotoxicity may be involved in spinal cord injury, stroke, traumatic brain injury, hearing loss (through noise overexposure or ototoxicity), and in neurodegenerative diseases of the central nervous system (CNS) such asmultiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease, alcoholismor alcohol withdrawal and especially over-rapid benzodiazepine withdrawal, and also Huntington's disease."
I believe this is what causes tinnitus. Therefore, it is VERY important to slowly taper off benzodiazapines. I don't have the time right now to research the "AMPA receptors" causing glutamatergic storms right now but maybe I can later. Right now I can state about the NMDA receptors. My theory that if the NMDA receptors can stop being overactivated the glutamatergic storm will be stopped or reduced (depending I guess on the AMPA receptors which I am not familiar with). NMDA antagonist therefore might help.
According to Wikipedia https://en.wikipedia.org/wiki/NMDA_receptor_antagonist it says that Magnesium is an uncompetitive channel blocker. You can look for more receptor antagonists on there. Therefore, I am wondering if Magnesium might help in benzo withdrawal tinnitus and hopefully benzo induced tinnitus.
Magnesium oxide can cause diarreah so it is best to take something like Magnesium Glycinate instead. Thus, it is my suggestion that if you have benzo induced tinnitus, you might could try Magnesium to see if lowers your tinnitus. If it does, I would suggest continue to use it unless it starts to increase tinnitus which in case you reduce or stop it. Again, I could totally be off the mark here because I am not scientist so you would have to try this at your own risk. I doubt it will get rid of the T but it may lower it. What do you guys think? Please comment. If I am wrong or this doesn't make sense let me know. I may look into later what "AMPA receptors are". If you guys know please comment on that as well. Thanks guys for reading.
Oh and also, I forgot to add: I would suggest avoid MSG which is monosodium glutamate and that there might be other drugs or supplements that could lower glutamate as well. You might could talk to a doctor about this stuff and see what he says.
"Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances. This occurs when receptors for the excitatory neurotransmitter glutamate (glutamate receptors) such as the NMDA receptor and AMPA receptor are overactivated by glutamatergic storm." Now later in the article it says this:
"Excitotoxicity may be involved in spinal cord injury, stroke, traumatic brain injury, hearing loss (through noise overexposure or ototoxicity), and in neurodegenerative diseases of the central nervous system (CNS) such asmultiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease, alcoholismor alcohol withdrawal and especially over-rapid benzodiazepine withdrawal, and also Huntington's disease."
I believe this is what causes tinnitus. Therefore, it is VERY important to slowly taper off benzodiazapines. I don't have the time right now to research the "AMPA receptors" causing glutamatergic storms right now but maybe I can later. Right now I can state about the NMDA receptors. My theory that if the NMDA receptors can stop being overactivated the glutamatergic storm will be stopped or reduced (depending I guess on the AMPA receptors which I am not familiar with). NMDA antagonist therefore might help.
According to Wikipedia https://en.wikipedia.org/wiki/NMDA_receptor_antagonist it says that Magnesium is an uncompetitive channel blocker. You can look for more receptor antagonists on there. Therefore, I am wondering if Magnesium might help in benzo withdrawal tinnitus and hopefully benzo induced tinnitus.
Magnesium oxide can cause diarreah so it is best to take something like Magnesium Glycinate instead. Thus, it is my suggestion that if you have benzo induced tinnitus, you might could try Magnesium to see if lowers your tinnitus. If it does, I would suggest continue to use it unless it starts to increase tinnitus which in case you reduce or stop it. Again, I could totally be off the mark here because I am not scientist so you would have to try this at your own risk. I doubt it will get rid of the T but it may lower it. What do you guys think? Please comment. If I am wrong or this doesn't make sense let me know. I may look into later what "AMPA receptors are". If you guys know please comment on that as well. Thanks guys for reading.
Oh and also, I forgot to add: I would suggest avoid MSG which is monosodium glutamate and that there might be other drugs or supplements that could lower glutamate as well. You might could talk to a doctor about this stuff and see what he says.
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