Member- Dec 18, 2015
- 618
- 45
- Tinnitus Since
- 03/2015
- Cause of Tinnitus
- Noise induced, loud rock concert
Calmaspray contains caroverine, you can give it a try. I know a guy from Polish tinnitus forum who claims it soften his T.
Tinnex (Caroverine)
- Thread starter Markku
- Start date
How does he know his t softened because of the caroverine. Sometimes t gets less loud over time.
- Dec 27, 2015
- 373
- Tinnitus Since
- May 2008
- Cause of Tinnitus
- Cochlear Endolymphatic Hydrops/Hearing loss
I've just recently heard about the drug Caroverine. It's been around a long time apparently. Has anyone heard of it and or used it in the USA? It's primarily used in India (known as Tinnex) & a few European countries. It comes in pill and injection form.
Like all of us, I've seen so many doctors in the US and not ONE has ever even mentioned this medicine. Any thoughts?
Like all of us, I've seen so many doctors in the US and not ONE has ever even mentioned this medicine. Any thoughts?
Pleasure_Paulie
Member
Read the rest of the thread, it's only 6 pages.
People have tried it with no success. If it was a viable treatment we would certainly know about it thus doctors don't know about it.
- Dec 27, 2015
- 373
- Tinnitus Since
- May 2008
- Cause of Tinnitus
- Cochlear Endolymphatic Hydrops/Hearing loss
@Pleasure_Paulie,
My recent post was merged into this thread. I hadn't seen it previously. I've read it now.
I guess I'll ask my doctor about it. Thank you.
My recent post was merged into this thread. I hadn't seen it previously. I've read it now.
I guess I'll ask my doctor about it. Thank you.
Randomised Controlled Clinical Study of Injection Caroverine and Ginkgo Biloba Extract in Cochlear Synaptic Tinnitus
Abstract
Tinnitus, also known as phantom auditory perception, is an annoying symptom and 13–17% of population reports bothersome tinnitus. Cochlear synaptic tinnitus is the most common type. Many treatments have been tried but none is yet considered to be well established. To evaluate effect of Inj.Caroverine and Ginkgo Biloba extract in cochlear synaptic tinnitus in terms of improving tinnitus grading, tinnitus matching and quality of life of patient. It is Randomised controlled study, conducted in department of ENT, on 86 patients, who met inclusion criteria, divided into 4 groups. Gr1—Inj Caroverin, Gr2—Inj Placebo, Gr3—Ginkgo Biloba extract, Gr4—Placebo as extract. A single dose infusion of caroverine immediately improves tinnitus grading and matching and provides immediate relief in reducing severity of tinnitus in 54.54% cases but improvement was not sustained in caroverine group at 3 month and 6 month follow-up after infusion. Ginkgo biloba also is effective in improving tinnitus grading and matching in 31.8% cases and improvement was sustained in ginkgo biloba group even after 3 month of cessation of treatment i.e. at 6 month follow-up. It is suggested that Inj.Caroverine as intravenous infusion should be given in severe cases of tinnitus to reduce its severity immediately and then patient should be put on Tab.Ginkgo biloba for a period of 3 months to provide sustained and long lasting relief. Thus combination therapy of Inj.Caroverin and Tab.Ginkgo Biloba, appropriately tailored to the need of patient will provide better results in greater majority of patients.
Source: https://link.springer.com/article/10.1007/s12070-019-01655-5
Abstract
Tinnitus, also known as phantom auditory perception, is an annoying symptom and 13–17% of population reports bothersome tinnitus. Cochlear synaptic tinnitus is the most common type. Many treatments have been tried but none is yet considered to be well established. To evaluate effect of Inj.Caroverine and Ginkgo Biloba extract in cochlear synaptic tinnitus in terms of improving tinnitus grading, tinnitus matching and quality of life of patient. It is Randomised controlled study, conducted in department of ENT, on 86 patients, who met inclusion criteria, divided into 4 groups. Gr1—Inj Caroverin, Gr2—Inj Placebo, Gr3—Ginkgo Biloba extract, Gr4—Placebo as extract. A single dose infusion of caroverine immediately improves tinnitus grading and matching and provides immediate relief in reducing severity of tinnitus in 54.54% cases but improvement was not sustained in caroverine group at 3 month and 6 month follow-up after infusion. Ginkgo biloba also is effective in improving tinnitus grading and matching in 31.8% cases and improvement was sustained in ginkgo biloba group even after 3 month of cessation of treatment i.e. at 6 month follow-up. It is suggested that Inj.Caroverine as intravenous infusion should be given in severe cases of tinnitus to reduce its severity immediately and then patient should be put on Tab.Ginkgo biloba for a period of 3 months to provide sustained and long lasting relief. Thus combination therapy of Inj.Caroverin and Tab.Ginkgo Biloba, appropriately tailored to the need of patient will provide better results in greater majority of patients.
Source: https://link.springer.com/article/10.1007/s12070-019-01655-5
@Sironketchup
You said in another thread you were in Bad Arolsen. One doctor told me they gave Caroverine there but I don't know if it's true. So I wanted to ask you. Do they give Caroverine infusions there? I know many people say it does not help, some say it maybe helps a little bit, so I'm curious.
You said in another thread you were in Bad Arolsen. One doctor told me they gave Caroverine there but I don't know if it's true. So I wanted to ask you. Do they give Caroverine infusions there? I know many people say it does not help, some say it maybe helps a little bit, so I'm curious.
Well, no information about duration of tinnitus, no specific test like TFI or THI.
I wonder what a tinnitus matching improvement is.
P-values are > and not <.
Finally there is no reference (n°21 missing) about the study led in Austria by Ehrenberg, whereas an Austrian clinic told me that its clinical study of caroverine had been withdrawn.
CLINICAL STUDY OF EFFECTS OF INJ. CAROVERINE AND GINKGO BILOBA EXTRACT IN COCHLEAR SYNAPTIC TINNITUS
I wonder what a tinnitus matching improvement is.
P-values are > and not <.
Finally there is no reference (n°21 missing) about the study led in Austria by Ehrenberg, whereas an Austrian clinic told me that its clinical study of caroverine had been withdrawn.
CLINICAL STUDY OF EFFECTS OF INJ. CAROVERINE AND GINKGO BILOBA EXTRACT IN COCHLEAR SYNAPTIC TINNITUS
Yet another suspicious hint of the Caroverine mystery:
journals.lww.com
Effect of oral caroverine in the treatment of tinnitus: A... : Journal of Family Medicine and Primary Care
nnitus. Hence, the present study was carried out to find the effect of oral caroverine in the treatment of tinnitus. Methodology: This quasi-experimental study was carried out on sixty consecutive patients of tinnitus. Thirty patients were given the usual standard of care consisting of Tab...
journals.lww.com
It seems that only 9 patients (those with mild tinnitus) showed improvement in the treatment group. It's an odd case, as the study appears to have only been conducted in India. Who funded it?Yet another suspicious hint of the Caroverine mystery:
Effect of oral caroverine in the treatment of tinnitus: A... : Journal of Family Medicine and Primary Care
nnitus. Hence, the present study was carried out to find the effect of oral caroverine in the treatment of tinnitus. Methodology: This quasi-experimental study was carried out on sixty consecutive patients of tinnitus. Thirty patients were given the usual standard of care consisting of Tab...
Where are the reports of failed trials from other countries?
I read the article, and I understand that Caroverine can be effective in treating tinnitus, but they don't know how long it can be used. Is that why you mentioned a "suspicious hint"?Yet another suspicious hint of the Caroverine mystery:
Effect of oral caroverine in the treatment of tinnitus: A... : Journal of Family Medicine and Primary Care
nnitus. Hence, the present study was carried out to find the effect of oral caroverine in the treatment of tinnitus. Methodology: This quasi-experimental study was carried out on sixty consecutive patients of tinnitus. Thirty patients were given the usual standard of care consisting of Tab...
StoneInFocus
Member
- Feb 21, 2022
- 503
- Tinnitus Since
- 2012
- Cause of Tinnitus
- Hearing damage, ear infections
They mention 'standard care' consisting of 'Tab. Cinnarizine 25mg twice daily along with fixed dose combination Cap. B-complex and Ginkgo biloba once daily.' Have you ever heard of this?
I think you need to import Tinnex from India if you don't live in Austria or Switzerland.
@StoneInFocus, I've heard of Cinnarizine being used for tinnitus, though it's not very common. Someone here described it as a "good old drug." I believe it's primarily used for vestibular issues.
There seems to be something questionable about these studies from India and Brazil. Only patients with mild tinnitus showed improvement? That's odd.
StoneInFocus
Member
- Feb 21, 2022
- 503
- Tinnitus Since
- 2012
- Cause of Tinnitus
- Hearing damage, ear infections
I don't think THI is a reliable metric anyway. There is also no placebo group.
I wouldn't take this study seriously.
Sorry for my late reply. Just take a look at my investigation:
Caroverine and Inner Ear Diseases
Tinnitus Talk submitted a new resource: Caroverine and Inner Ear Diseases (version 1.0) - The study will investigate the transtympanic treatment with a 1,5% caroverine solution. This trial is a randomized, double blind, placebo controlled study on patients suffering from inner ear diseases...
www.tinnitustalk.com
