Tinnitus and Tonotopic Remapping of the Auditory Cortex
Pim van Dijk, Ph.D., Emile de Kleine, Ph.D. and D.R.M. Langers, Ph.D., University Medical Center Groningen, Groningen, The Netherlands
Funding: $50,000
Roadmap to a Cure: Pathways A, B & C
Tinnitus is believed to be related to changes in the brain, specifically a process referred to as tonotopic reorganization. (Tonotopy is the organization of how particular sound frequencies are processed in different areas of the brain.) Reorganizaiton may lead to an overrepresentation of particular sound frequencies in the brain, which leads to the perception tinnitus. Several therapies have been proposed to restore normal tonotopy, and thereby possibly cure tinnitus.
However, the underlying assumption that tinnitus is caused by tonotopic reorganization has never been fully tested in humans. Dr. Van Dijk's project addresses this gap in the research. For the first time, researchers will used a new state-of-the-art functional magnetic resonance imaging (fMRI) to robustly measure detailed tonotopic maps in subjects with and without tinnitus will be tested. By a comparison of these two groups, it will become clear to what extent tinnitus is associated with the manifest tonotopic reorganization.
If it is affirmed that tinnitus is related to tonotopic reorganization in the human brain, it will strongly stimulate the development of therapies (such a new sound therapies) that aim to restore normal tonotopic representation and thereby cure tinnitus.
http://www.ata.org/research/ata-funded
Pim van Dijk, Ph.D., Emile de Kleine, Ph.D. and D.R.M. Langers, Ph.D., University Medical Center Groningen, Groningen, The Netherlands
Funding: $50,000
Roadmap to a Cure: Pathways A, B & C
Tinnitus is believed to be related to changes in the brain, specifically a process referred to as tonotopic reorganization. (Tonotopy is the organization of how particular sound frequencies are processed in different areas of the brain.) Reorganizaiton may lead to an overrepresentation of particular sound frequencies in the brain, which leads to the perception tinnitus. Several therapies have been proposed to restore normal tonotopy, and thereby possibly cure tinnitus.
However, the underlying assumption that tinnitus is caused by tonotopic reorganization has never been fully tested in humans. Dr. Van Dijk's project addresses this gap in the research. For the first time, researchers will used a new state-of-the-art functional magnetic resonance imaging (fMRI) to robustly measure detailed tonotopic maps in subjects with and without tinnitus will be tested. By a comparison of these two groups, it will become clear to what extent tinnitus is associated with the manifest tonotopic reorganization.
If it is affirmed that tinnitus is related to tonotopic reorganization in the human brain, it will strongly stimulate the development of therapies (such a new sound therapies) that aim to restore normal tonotopic representation and thereby cure tinnitus.
http://www.ata.org/research/ata-funded