What's the Difference Between Autifony AUT00063 and Auris Medical AM-101?

[Rudy]

What are the difference between these 2 drugs under trial. Are they both for T and H? Hearing loss or Noise Induced? How much longer of a wait are we looking at for these

Thanks!

 

[linearb]

AM-101 is ketamine, an old drug -- the only thing that's new is that it's a gel formation which is injected directly in to the ear. So, it's relatively invasive.

AUT00063 is a selective potassium channel modulator, which is a mechanism of action which has never really been explored for hearing disorders, and there are only one or two other drugs which have a similar mechanism, which are much less narrowly targeted. This drug is expected to be available as a normal pill you swallow.

AM-101 is closer to mass market; they have done a bunch of phase-III trials (larger groups of people than phase II). AUT00063 is expected to enter phase III at the beginning of next year.

Optimistically, if AUT00063 works out at all in the trials, it might be on the market in 2017/2018.

 

[Atlantis]

What are the difference between these 2 drugs under trial.

One failed while the other has not yet.