Why Do So Many People Hear a Hissing Sound?

[2noist]

I would love to know why some hear ringing, others hissing, etc. What causes the difference in what we hear?

 

[Michael Leigh]

I would love to know why some hear ringing, others hissing, etc. What causes the difference in what we hear?

Tinnitus is a complex condition that no two people will experience the same. I don't think anyone knows why the difference in sound occurs between people. It's probably the reason they are all defined as tinnitus.

 

[Forever hopeful]

Hello there,

I think I was referring to your mention of allergies, which of course, are histamine mediated.

Prof. Geoffrey Abbott wrote a paper about Quercetin's ability to modulate potassium channels. From speaking with him, he has stated that histamine blocks potassium channels. I think that this is how Quercetin impacts Kv ion channels by removing excess histamine. You only have to look around the histamine intolerance groups to realise just how many people out there suffering with tinnitus at the hands of a potentially simple therapeutic approach.

I have never bought that hearing loss directly causes tinnitus, given my hearing loss is stable, but my tinnitus fluctuates.

I think there is something else going on that can exacerbate it. This is what led me to looking more deeply into histamine intolerance/mast cell activation disorder.

You probably know that Prof. Bao at the University of Arizona has found raised levels of TNF-alpha in the auditory parts of the brain and cochlea of noise injured mice. Most likely, histamine is involved in the downstream effects of a heightened immune response to hearing damage.

I can't find it now due to sever brain fog, but there is a French study suggesting that H1 and H2 blockers may be detrimental to tinnitus, whilst H4 blockers may be helpful. Quercetin is a H4 blocker, as is Coleus.

Just my thoughts.

I just noticed that you wrote about H2 blockers being detrimental to tinnitus. I take Pepcid fairly regularly due to GERD. And I had switched from the PPIs because I thought I'd read the PPIs are detrimental to tinnitus. And of course the Zyrtec I have to take every day for my allergies is a H1 blocker. I can't win.

 

[Leeroy]

Hey @DebInAustralia, you mentioned Quercetin to help with histamine release. Is there anything else supplementary that you know of doing this?

 

[DebInAustralia]

Hey @DebInAustralia, you mentioned Quercetin to help with histamine release. Is there anything else supplementary that you know of doing this?

I am sorry for the delay.

The only other H4 inhibitor that I know of is Coleus but I haven't tried it yet consistently.

I have low histidine (precursor to histamine) and am starting supplementing with this (regulates histamine). Apparently, it is common in cases with low histidine to have high histamine.

I was speaking to a biochemist yesterday who uses l-histidine to contain her allergies and tinnitus.

MCAS is common in perimenopause and chronic infections (I have Lyme.)

 

[Nick47]

The only other H4 inhibitor that I know of is Coleus but I haven't tried it yet consistently.

@DebInAustralia, here are some H4 antagonists: