Will There Be a Cure Within the Next 20 Years, What Do You Really Think?

[DaveFromChicago]

Allan 1967:
Your insightful encapsulation of these frankly fantastic advances in Medical Technology is thankfully acknowledged.
Yesterday our Chicago Tribune had a major article in the Business Section regarding the FDA approval and release of the drug Ketamine, which should significantly benefit 7.4 million Americans who have severe depression that is not improved by traditional SSRI drugs. The accrued revenues from the drug's distribution should be huge.
There is also an unrelated on line entry that actually states that Ketamine will also reduce tinnitus. Has this been substantiated?
As a further addition to your Medical Technology Report:
Severe Acne and oily skin was regarded as untreatable until 1983, when the superconcentrated Vitamin A drug Accutane was introduced. It has acted as a veritable lifetime vaccine in eliminating these conditions.
The skin condition known as an Angioma (or the Port Wine stain) was regarded as virtually untreatable until 1987, when the Dye Laser was introduced that incinerated the affected area so that normal skin without any scarring or dilated blood vessels would grow back. Now every dermatologist's office has such a device.
Such revolutionary treatments give real hope regarding the possibilities for actual effective tinnitus elimination (which might actually be discovered by chance or when we least expect it).

 

[Allan1967]

Every week I'm seeing something positive happening - Frequency Theraputics, Nueromod: Susan Shore etc etc but every week I wake up and realise NOTHING has been made available to us.

NOTHING.

When are all these projects going to come to something that I can see/feel/touch and TRY??

Right now we're just drifting in limbo waiting for something to actually happen.

 

[DaveFromChicago]

Allan 1967:
I fully appreciate your sentiments.
Recently, my wife invited a friend over. I had one of those You Tube sound masking sites on. After about 90 seconds, she said "Could you please turn that very annoying sound off?"
In such instances, my very elaborately constructed CBT/TRT habituation program will utterly collapse like a proverbial House of Cards. When such an opinion is received from "the outside"(someone who has never had tinnitus nor ever heard of it), I am compelled to notify myself that "She is right - Living under this constant state of tinnitus is irremediably insane."
Habituation consists in straining to the utmost to pretend that an unbearably, unchangeably endless condition will yield to some sort of ultimately happy conclusion.
It reminds be of that exchange in Samuel Beckett's "Waiting for Godot":
Vladimir: We can't go on like this.
Estragon: That's what you think.
After over five years of waiting in vain for any effective treatment and/or drug, it is increasingly difficult not to cave in to abysmal despair.
Incidentally, do we dare inquire about BAM's status? Is there any conceivable way to find out about him?

 

[JohnAdams]

every week I wake up and realise NOTHING has been made available to us.

I guess everyone here thinks I'm lying about my improvements from my bone marrow/PRP treatments. Oh well. I guess that's nothing.

 

[Jack Straw]

Cure? Probably not. Treatment? Yes

 

[DaveFromChicago]

To John Adams:
Your point is very well taken. I would love to be notified of a revolutionary breakthrough treatment for this.
There are two essential, important questions that require an answer for hopefulness to be achieved:
1) What will it consist of?
2) When will it be available?

 

[JohnAdams]

Cure? Probably not. Treatment? Yes

Dr. Shim told me that he has successfully brought people back to silence. He also told me that if he can get to a patient quickly after the onset of their hearing loss/tinnitus that they almost always completely recover.

To John Adams:
Your point is very well taken. I would love to be notified of a revolutionary breakthrough treatment for this.
There are two essential, important questions that require an answer for hopefulness to be achieved:
1) What will it consist of?
2) When will it be available?

1. It consists of multiple injections of PRP and bone marrow into the middle ear.
2. If you want to fly around the world, then now. If we could get some local ENT's and or otolaryngologists to administer this very simple procedure then there would be no need to travel so far.

 

[DaveFromChicago]

Thanks very much. The only unfortunate feature about this 20 year (very believable) prediction is that I will be 65 in May and may not live to experience this.

 

[Allan1967]

Allan 1967:
I fully appreciate your sentiments.
Recently, my wife invited a friend over. I had one of those You Tube sound masking sites on. After about 90 seconds, she said "Could you please turn that very annoying sound off?"
In such instances, my very elaborately constructed CBT/TRT habituation program will utterly collapse like a proverbial House of Cards. When such an opinion is received from "the outside"(someone who has never had tinnitus nor ever heard of it), I am compelled to notify myself that "She is right - Living under this constant state of tinnitus is irremediably insane."
Habituation consists in straining to the utmost to pretend that an unbearably, unchangeably endless condition will yield to some sort of ultimately happy conclusion.
It reminds be of that exchange in Samuel Beckett's "Waiting for Godot":
Vladimir: We can't go on like this.
Estragon: That's what you think.
After over five years of waiting in vain for any effective treatment and/or drug, it is increasingly difficult not to cave in to abysmal despair.
Incidentally, do we dare inquire about BAM's status? Is there any conceivable way to find out about him?

I've been waiting since 1997, forgot about it for a while and now am chomping at the bit for a cure.

 

[Allan1967]

I guess everyone here thinks I'm lying about my improvements from my bone marrow/PRP treatments. Oh well. I guess that's nothing.

I'm aware of your story John but it's quite unique.

 

[Allan1967]

Allan 1967:
Your insightful encapsulation of these frankly fantastic advances in Medical Technology is thankfully acknowledged.
Yesterday our Chicago Tribune had a major article in the Business Section regarding the FDA approval and release of the drug Ketamine, which should significantly benefit 7.4 million Americans who have severe depression that is not improved by traditional SSRI drugs. The accrued revenues from the drug's distribution should be huge.
There is also an unrelated on line entry that actually states that Ketamine will also reduce tinnitus. Has this been substantiated?
As a further addition to your Medical Technology Report:
Severe Acne and oily skin was regarded as untreatable until 1983, when the superconcentrated Vitamin A drug Accutane was introduced. It has acted as a veritable lifetime vaccine in eliminating these conditions.
The skin condition known as an Angioma (or the Port Wine stain) was regarded as virtually untreatable until 1987, when the Dye Laser was introduced that incinerated the affected area so that normal skin without any scarring or dilated blood vessels would grow back. Now every dermatologist's office has such a device.
Such revolutionary treatments give real hope regarding the possibilities for actual effective tinnitus elimination (which might actually be discovered by chance or when we least expect it).

Impotence has also been cured and I know things are getting cured or at least made better.

At the minute, all these good things that are happening, just dont seem to have an endgame.

 

[grate_biff]

I guess everyone here thinks I'm lying about my improvements from my bone marrow/PRP treatments. Oh well. I guess that's nothing.

I believe you. It would be really nice to see pre and post audiograms though. That would be just awesome.
Hope your recent spike settles real soon!

 

[Lucifer]

Just wanted to ask if anyone knew what drugs are currently being clinically tested to cure tinnitus?

 

[Autumnly]

I'd really recommend you to have a look at the research section and to use the search function.

Devices Against Tinnitus

• Lenire by Neuromod is coming to the European Market in 2019, hopefully soon afterward to the US and other countries
• University of Michigan
• University of Minnesota

Spoiler

Hair Cell Regeneration (regrow hair cells)

• Frequency Therapeutics - FX-322, Phase 2 should begin in 2019
• Otonomy - OTO-6XX, Phase 1/2 begin 2019
• Audion - Regain, in Phase 1/2
• Genvec / Novartis, in Phase 1/2 (estimated completion date: 2020)
• Hough Ear Institute + Otologic Pharmaceutics
  • injection - silencing RNA
• OTOSTEM (Horizion2020)
  • A cell-based treatment introducing stem/otic progenitor cells into the cochlea
  • a drug-based treatment to protect or regenerate sensory hair cells.
• Akouos - hereditary hearing loss - gene therapy
• Columbia University Medical Center
• Harvard University
• Stanford University
• University of Southern California
• ...

Repairing Synaptic Damage (Hidden Hearing Loss)

• Affichem - AF-243
• Otonomy - OTO-413
• Hough Ear Institute + Otologic Pharmaceutics
  • pill - NHPN-1010: to treat acute noise-induced hearing loss and tinnitus, regrows the nerve endings and reforms the synapses. phase 1 completed
• Decibel ???
• Bionics Institute and University of Melbourne
• USC and Harvard
• ...

Acute Hearing Loss

• Stekin AG - STR001-IT and STR001-ER
  • in Phase 3
• Soundpharmaceuticals - SPI-1005 (NIHL, mild - moderate)
• Sensorion - SENS-401 (SSNHL)

Kv // Potassium channel modulators

• Xenon Pharma
  • XEN-1101, Kv7 (new retigabine, for epilepsy)
  • phase 2 to begin by the end of 2018
• SciFluor
  • KCNQ2/3 Activator to treat epilepsy
  • SF0034
• Autifony
  • AUT00063, Kv3.1
  • phase 1 hasn't started yet (?)
• Prof. Tzounopoulos - University of Pittsburgh
  • specific Kv7.2/3 agonists
• Knopp Biosciences
  • Kv7 platform

Ion Channels - Peptides

• Cognosetta
  • a drug target and candidate peptides for improving electrophysiological and behavioral measures of tinnitus and age-related hearing loss

NMDA receptor antagonist

• Otonomy - OTO-313 (probably for acute tinnitus; not yet specified)
• Esketamine (brand name: ketanes; for TRD)
  • phase 3 completed nov 2017
• SAGE Therapeutics
  • SAGE-718 (NMDA-Hypofunction)
    • in Phase 1

GABA

• SAGE Therapeutics
  • Brexanolone (formerly SAGE-547, postpartum depression)
    • Phase 3 complete, now: Registration
  • SAGE-217 (Major Depressive Disorder)
    • in Phase 3
  • SAGE-324 (Epileptiform Disorders)
    • Preclinical

MDMA

• Maps - two Phase 3 clinical trials of MDMA-assisted psychotherapy in patients with severe PTSD starting in 2018

Drugs Against Ototoxicity

• Decibel Therapeutics, in Phase 1
• University of Washington, HHF: ORC-13661

 

[PeteJ]

https://www.nih.gov/news-events/news-releases/rebooting-brain-helps-stop-ring-tinnitus-rats

I read a thread of a pill that was used in mice.

This is different but again, mice play the role of the 'Guinea pigs.'

I thought it sounded promising but it was approximately 8 years ago!

How many different research studies are there and where does it go?!? It seems so discouraging and hopeless. I think they all just want money. Nothing seems to go anywhere and the progress is slow and ultimately uneventful. Tinnitus is really complicated and it seems all research/researchers are not coming up with a universal solution that will cure or solve this condition.

 

[Claire1210]

I would love to wake up one morning and the words cure found popped up but unfortunely I don't think this will ever happen. Happy to keep donating for research though x

 

[glennbama]

I have been on Tinnitus Talk for about a month now and can't tear myself away from all the good reading. I say good a little tongue in cheek since there are people suffering out there and some of their stories bring me to tears (praying for all). There is more research out there then a person can read. I am interested as to whether anyone has or would take a shot at putting a timeline together for the top research that is taking place. I guess if I continue reading enough I could figure it out for myself but was just hoping someone may have done this already or is in the process. I am having my second bout of sudden hearing loss in the same ear (right). My hearing improved after the first bout but the second one is much worse and brought with it some horrendous tinnitus. I've had three shots of steroids to the ear drum about two weeks ago and am waiting for any signs of improvement. I am about to turn 65 so hearing research that is ten or more years away is a bit discouraging but I know they are doing the best they can.

Anyway, if anyone knows the general timelines for some of the top research it would be a great post that could be used by everyone including those who have yet to join this forum.

Thanks in advance for any efforts!!

 

[Bill Bauer]

Anyway, if anyone knows the general timelines for some of the top research it would be a great post that could be used by everyone including those who have yet to join this forum.

Thanks in advance for any efforts!!

Is this what you might be looking for?

Hearing Regeneration Trials

Spoiler

Frequency Therapeutics - FX-322
in Phase 1.5 (Results: December 2018)
Phase 2 (begin 2019)
Audion / Regain Trial
Phase 1/2 ongoing in the UK
Genvec / Novartis - CGF166
Phase 1/2 ongoing

Trials to begin in 2019 / Things to look out for in 2019

Spoiler

Neuromod (Lenire)
launching their new device in January 2019 starting in Ireland, then Europe, then the US
results of their latest trial: 1H2019
Xenon Pharma - XEN-1101
Phase 2, expected to wrap up in 2nd quarter 2020
Frequency Therapeutics
Phase 2
Otonomy
1H19: OTO-313 (reduce tinnitus) Phase 1/2
1H19: OTO-413 (repairing synaptic damage) Phase 1/2
OTO-6XX (hair cell regeneration)
2H18: candidate selection
2019: Phase 1/2
University of Minnesota (device for tinnitus)
Phase 3 ?
University of Michigan (device for tinnitus)
perhaps updates on their currently ongoing trial
Estimated Primary Completion Date: September 2022
Estimated Study Completion Date: January 2023