Recent content by Chetan

What I see on the site is they "announced" positive data on April 9th, 2019: Frequency Therapeutics Announces Positive Phase 1/2 Data for Drug Candidate for Hearing Restoration For someone who was asking why they couldn't enroll in Q4. I would be rather surprised about this, because if they...

Likely in Q1/2022 if they get FDA approval in Q4/2021. That's my guess.

Folks concerned about recent weakness. It's all part of biotech ETF rebalancing. I confirmed my statement Friday when I made this claim today, XBI added 1.5%, over 520k shares to their existing 345k position to get to 872k shares. I'm sure other institutes were front running and making money...

82 words improved collectively across 6 people. Average improvement is 82/6. Multiple by 2 to get a score improvement (since 50 word test). That gets you 27%. Remove the 4 word improvement 6th patient. Becomes 78 improvement, divide by 5 patients for average word improvement, multiple by 2...

Yep, I basically looked at the average improvement seen in the moderate hearing loss responder population in absolute numbers, then I looked at this with a lens of counting all 6 patients vs counting 5 patients. If I count all 6, you get 82 words improved across 6 people, which amounts to 27%...

It absolutely will be a huge biotech story, and the reason why I'd be happy with even 1% (aside from financial implications) is I view this like a mathematical "existential proof" if you are familiar with the concept. Such proofs are done to prove QED that there exists a solution to a problem...

Wow, I hadn't realized how intensely they blind the studies involved! This is the first trial I've ever encountered with quadruple blinding (participant, care provider, investigator, and even the outcomes assessor). I've literally never encountered this in my time before, most trials stick to...

Cherry picking patients to prove there is a statistically significant difference between placebo and treatment is good science as someone else said. Nothing sinister. All of the trials this year are intended to identify the broadest widest set of participants that will be responders and be...

That makes sense given the hidden WR deficit requirement to participate in the trial. I'm really curious how they use WR deficit, if they use WR quiet or WIN or an average or needs both to have deficit. Very interesting signal, I am unsure if this means no tinnitus participants in study, I...

In my opinion that is why they biased the Phase 1b trial to be 2:1 ratio of mild severity vs moderate severity SNHL. And yeah the stem cell confusion is serious. One of my buddies I discuss biotechs with had the same confusion and he's a very intelligent guy, so the confusion is wide spread...

In Aaron's words copy pasting this from another chat thread we had: "1) Cell fate. Unlike stem cells, progenitor cells have a pre-determined cell "fate". If you watch the video, you learn that half of Will McLean's research was simply figuring out which progenitor cell becomes a hair cell (the...

Your wish is my command. Consider him educated. And yeah the point on KOL talk that they aren't sure about is if damaged hair cells see no benefit but are looking to the trial to inform is interesting, I'm hopeful but setting conservative expectations, though it makes sense to me that some...

Yep I saw that, I agree FWIW with your WR deficit range, based on Raffin table for statistical significance ranges + clinically meaningful I expect WR deficit range minimum is likely between 70-85% minimum, WR deficit needed to be eligible. If they did do long term onset hearing loss criteria in...

I think if Phase 2a succeeds, eventually they can figure out how to penetrate deeper. All we need is confirmation the drug works in a meaningful way. It's a drug delivery problem, not an efficacy problem that prevents lower frequencies. This can be solved. For all we know, Frequency...

Making money would be nice, but I'm here as much for being part of a history defining moment of real clinical stat sig evidence that regenerative medicine is here and possible (with hearing loss benefitting). My dad has a hearing aid and tinnitus and as I've understood the area more I've grown...