Recent content by jcloth

Science Magazine Recognizes Frequency Therapeutics’ PCA Regeneration Technology as a Breakthrough in Regenerative Medicine https://www.businesswire.com/news/home/20180320005327/en/Science-Magazine-Recognizes-Frequency-Therapeutics’-PCA-Regeneration

Frequency steals Otonomy’s CSO: https://www.businesswire.com/news/home/20180312005344/en/Frequency-Therapeutics-Welcomes-Otonomy-CSO-Executive-Vice “Since I’ve been monitoring scientific advances in hearing regeneration over the last decade, I consider Frequency’s PCA Regeneration platform a...

I don't think OAEs measure above 8k, just like standard hearing tests. Mine didn't anyway. Listen to a frequency sweep on low volume on decent full range headphones or speakers and see what happens at the higher frequencies. Probably some hearing loss there

Three-way Collaboration with the U.S. Army, Harvard University and Frequency Therapeutics to Focus on Progenitor Cell Regeneration in Muscle http://www.digitaljournal.com/pr/3660478

You're thinking of auditory neurons. Synapses connect hair cells and neurons, they necessarily die when hair cells do.

Synapses without hair cells are not possible. They are connecting fibres. If a hair cell goes, its connection to the auditory nerve goes.

My hopeful speculation (based on nothing) is that if these deafferented hair cells are near to missing hair cells, the regeneration process might release neurotrophic factors or other signals that cause these to re-synapse as well. :whistle:

I'm hopeful that restoring input (by regenerating hair cells in the case of FX) will alleviate hyperacusis as well as tinnitus. I think it's very telling that a high dose of sodium salicylate (aspirin) induces hyperacusis and tinnitus as well as moderate hearing loss by disrupting hair cell...

I guess that there is not a straightforward answer because it depends on the toxin. Some drugs may destroy just the hair cells, in which case FX-322 will (theoretically) work, some may destroy supporting cells as well, in which case FX-322 will have no effect.

As far as I understand it, the dead cells are cleared away/reabsorbed by the body and are no longer present at all, so regenerated hair cells will be in their place not "next to" dead cells...

I think this may be a misconception about how hair cell damage causes tinnitus. It's likely that the brain amplifies frequency bands where there is reduced signal, i.e dead hair cells/synapses/neurons. So your perception of ringing is not necessarily evidence that hair cells are "alive and well"

I guess that's like asking how tinnitus goes away along with hearing loss associated with a high dose of aspirin, or how it goes away after emerging from a soundproofed booth. The brain is producing the sound but when input is restored the brain stops doing this. I'm sure that there are a few...

4. Aspirin at high doses, which causes temporary moderate hearing loss, also causes temporary tinnitus (and hyperacusis): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341117/ 5. Most people experience tinnitus after spending a few minutes in a soundproofed room, presumably due to lack of...

https://www.theguardian.com/science/2017/dec/20/breakthrough-for-genetic-hearing-loss-as-gene-editing-prevents-deafness-in-mice

No new information really but here's a podcast about Frequency: