Recent content by xanaxvictim

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    Conotoxin

    http://onlinelibrary.wiley.com/doi/10.1002/anie.201000620/abstract The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain Maybe the next thing to try
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    Retigabine (Trobalt, Potiga) — General Discussion

    ZnPy is a very commonly used chemical unfortunately it doesn't cross BBB so the only way to get it to the brain is injection into the spine, not practical in any way. Another method is develop another molecule which has a similar MoA on the receptor but cross BBB, which can be a monumental...
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    Dear attheedgeofscience I Need Your Valuable Opinion

    Dear @attheedgeofscience, Thank you very much for sharing with us your theory regarding hearing loss and T and your experience with LLLT/stem cell/HIFU. I developed T during mid-Oct and when I went to ENT/Audiologist at late Oct my hearing test turned out normal. T didn't go away and I went to...
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    Retigabine (Trobalt, Potiga) — General Discussion

    Bad news. Can't get my neurologist prescribe RTG he read all the pre-clinical studies I presented to him but he told me he's reluctant to prescribe it because there's no clinical data to support the use of RTG. He didn't even prescribe me Tegratol. He told me "I'm sorry there's nothing I can do...
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    Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus

    I only wish that AUT is successful and won't lose its efficiency after a short while like RTG apparently does
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    Retigabine (Trobalt, Potiga) — General Discussion

    always bear in mind that this is NOT a double blinded placebo controlled trial with rigorous protocol to follow, like the AUT-00063 trial does (which IS a double blinded trial). Even with double blinded placebo controlled trial there is a problem of replicability. Interpretation of clinical...
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    Retigabine (Trobalt, Potiga) — General Discussion

    That's a bad news, really bad news I would like to see some trialees who have reported drastic change in T level (some even reported hearing silence or near silence) doing the same test plus there are more negative outcome progress reports recently, my heart sinks to the bottom of the sea
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    Diffusion Imaging (dtiMRI) of Auditory and Auditory-Limbic Connectivity in Tinnitus

    Not sure if anyone has posted this study before http://www.hindawi.com/journals/np/2014/145943/ Application of high resolution dti MRI on studying brain disorder http://www.ncbi.nlm.nih.gov/pubmed/22677150
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    Retigabine (Trobalt, Potiga) — General Discussion

    muscarinic receptor signaling reduction of PIP2 I have a gut feeling that this may have something to do with the loss of effectiveness of RTG after long term use, anyone interested in researching into this issue? http://www.ncbi.nlm.nih.gov/pubmed/23650395 Pharmacological augmentation of...
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    Retigabine (Trobalt, Potiga) — General Discussion

    @amandine I think the only way we can know the objective loudness of a subjective T is by minimum dB of masking white noise not the TQ stuff which is subjected to psychological effects. By using masking sound you either hear T or not. This is potentially valuable in validating whether the...
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    Retigabine (Trobalt, Potiga) — General Discussion

    He had made it very clear, there is NO double blind placebo controlled study that confirm RTG is effective. and he believed that RTG does not work because in the past all candidate drugs failed double blind placebo controlled trials so he does not believe there exists a pharmacological approach...
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    Levetiracetam (Keppra) — Another Possible Potassium Channel Modulator?

    Tinnitus? The medical community doesn't even give a shit They tell you to go for an MRI and if there's no tumor they tell you there's no cure learn to live with it it's not going to kill and then kick you out of the clinic or better tell you to listen to Goddamn white noise for the rest of your...
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    Levetiracetam (Keppra) — Another Possible Potassium Channel Modulator?

    For those lab rats on TT we seem to have a continuous supply of novel molecules to play with Brivaracetam (UCB 34714), similar to Keppra but 10 times more potent, currently under Phase III trial http://www.ncbi.nlm.nih.gov/pubmed/17199019...
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    Retigabine (Trobalt, Potiga) — General Discussion

    Regarding the Flupirtine question I did found an article dating from 2006 stating that it is not effective at a dosage of 2*100mg daily against T http://www.ncbi.nlm.nih.gov/pubmed/17114151 May I know where have you seen reports saying that it is useful against T? I don't know but people are...
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    Levetiracetam (Keppra) — Another Possible Potassium Channel Modulator?

    Many A/D and tranquilizers can cause T, yet ironically they are frequently prescribed to T sufferers to help them cope with the situation. It is well understood that withdrawing from benzo can cause T and H (look at benzobuddies to see all those poor souls who got T and H due to benzo withdrawal).