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I was diagnosed with bruxism by my dentists. I also have a mild TMJ due to clenching my teeth. I am on my way to recovery!

My ENT experience today was nice. My second ENT ever. Have a nice Friday everyone!

Oh boy. I have basically been sick since start of this year. I hope fever does not go up much so I can make it to the ENT tomorrow.

I have been dealing with sinus issues lately. Pain and pressure feeling but no congestion. Going to see ENT for some medicine.

Yeah! If the supplements are safe, there is no harm to keep experimenting. I have seen those numbers and it makes me sad how people are deceived with the products. I chose to experiment with Quercetin since I read that it could also help with allergies since it is a natural antihistamine. I live...

Does anyone have any experience from "longevity" supplements? I have decided to try NMN and Quercetin. Just for a while to see if I get any benefits.

You are welcome my friend! :) I hope you are able to watch the whole interview! I have watched many of Aubrey's interviews and yeah, there is something about the voice. I have fallen asleep a couple of times while listening to him talking about the research and thoughts :sleep: I will...

Hi! Yes, actually he does mention intermittent fasting and plant based diet (or at least to keep the glucose levels low). Also, cold exposure and sleep. Those are things he mentioned everyone can do at the moment. Even if we would get these kinds of treatments soon enough, it doesn't mean that...

Reversing aging as a research field is getting bigger since many are now considering aging as a disease. More money is invested into this. There are billion dollar companies trying to solve these issues. There are many scientists who disagree and agree on various things that might cause the...

In my opinion human life is too short. Way too short. So much worry, stress, and pain. I strongly believe that expanding health span and lifespan together would bring many good thins to our lives. You would have time to see everything you want. No worry of "wasting" time. You could change...

I had an ear canal and middle ear infection in January. After the Amoxicillin and Cetraxal (Cipfofloxacin) ear drops, the symptoms started to fade. But two weeks ago those symptoms started to creep back in. My ear feels slightly clogged and sharp/dull pains come in waves. There seems to be no...

There is a glimmer of light after all these failures! Maybe Spiral Therapeutics can get better results. Have they given any specific details about the delivery method?

Lol NMN was banned in the USA. I live in Europe and decided to try NMN. I have been feeling down lately and would need some energy boost to start exercising again.

This is a step forward. We are starting to see a lot more of these discoveries of hearing regeneration. More and more people and companies are looking in to this and that makes me glad. Science can be very slow but we will get there. I believe in the near future the whole regenerative medicine...

I agree. I still think that the issue is how to get enough drug to the cochlea and make it survive to trigger the regeneration. Damn, I wish that one of the companies could try it one more time. I'm glad that other companies are pursuing the same with different approaches.

I get your point. It is like a double-edged sword. But I try to see the positive. Think about how scientists and innovators could spend their prolonged life span to keep going. But yeah, someone with bad intentions could do the same. This will be the future at some point to have the choice to...

Yes, the point is not to prolong suffering but rather make the body young to end the suffering! :cool: There would be no point to live long but not be functional. I would give anything to warp my body back in time to heal ears and tinnitus :p Maybe I could become a lab rat but I am still under...

Yes, I was both angry and sad yesterday. I'm already looking into other companies with a cautious mind. I'm still a little sad because it seems nobody will continue Frequency Therapeutics' work. Does it even matter that Astellas owned the rights to develop and market both products outside of US...

Are there any details on how this drug delivery works? Exactly! Like Sound Pharmaceuticals, Acousia Therapeutics, Lineage Cell Therapeutics and Rinri Therapeutics.

I have not followed what happened to this product. Seems like they ruined it with the dosing? There are companies other than Otonomy but none of them are in clinical trials. I don't think there will be clinical trials this year by anyone to target hearing loss at least.

I gave up my dream to become a doctor. It has been too stressful studying for the entrance thus making my T worse.

It seems not. I checked the website and SPI-5557 is still waiting for Phase 1. How long has it been like that? It seems the IND has not yet been filed. Well the science behind it looks promising by suppressing the p27Kip1 to promote regeneration in adult tissue. Hell, it is saying that it should...

So this means it is pretty much the end of the hearing regeneration for the company. "The Company will immediately reduce headcount as part of an overall restructuring, downsizing personnel by approximately 55 percent."

I do agree that even if the effects were slight (even this would be an improvement), they should push it to the market to keep things going forward which of course depends on the FDA and study results. I bet there are a lot of other drugs in the market that have very minor effects, if any at...

David Sinclair is saying that it will be available for everyone. Yeah, at first it would make sense that only the super rich can have it but thinking how much old age costs to society, I think that at some point we can all have it. Next question is the over population question. Yes, in some...

Hi! I wanted to start a discussion about aging since it is a topic that will affect all of us. I find David Sinclair's research very fascinating. They are literally trying to stop and reverse aging. They have had success already with mice studies. Making a mouse a lot older and then reversing...

I think $300 is cheap considering what the injection could potentially achieve.

Yes, I guess so. Actually I have not thought about this earlier. Found a link about FDA's office in Europe. Not sure yet what does it mean. Maybe someone wiser could enlighten me about it. Surely many of us here are from Europe, not just US. I would be amazed if EU would not approve the...

Health care systems have differences. For example, here in Finland we have a public health care system. Eager to see if FX-322 & FX-345 reaches the market, when and how it will be administered in Europe.

This song is nostalgic to me. Reminds of the summers of my childhood :) I really like the voice of Ville Valo!

I know this might have been discussed over and over again in the threads, but how much would this kind of treatment possibly cost if it reaches the market? 100 dollars? 1000 dollars? More? I think the small molecules are pretty cheap to make but maybe the injection procedure costs more? :)

I have not posted in this thread for almost 4 years. I gotta say that it exceeded my expectations with the word recognition scores. I hope they would have tested audiogram with higher frequencies since FX-322 is supposed to target those. I hope we would hear the results soon and get promising...

Before my recent relapse, I used to run and go to gym occasionally. Now I have been just sitting inside my apartment unable start exercising again.

I think last night for the first time ever in my life I experienced short pulsatile tinnitus in my right due to anxiety. My heart was racing

Yes, I guess I just have to believe it too. I was also discussing the tinnitus measurement with the audiologist today. She said that younger audiologists don't even know how to do it nowadays. Before I left the office, she said that almost everyone experiences tinnitus at some point in their lives.

Hola! I just had my audiogram. Last time was 4 years ago and back then frequencies up to 8 kHz were 5-10 dB but it was not in soundproof space. This time it was. I was a little nervous before going but here are the results. What do you think? I am turning 28 in a couple of months.

How long have you been boxing?

Hi all! Technically I am not new here but wanted to give a face to my profile! I have been on and off from this forum but recent anxiety made me come back.

Defenitely I will have to try Elden Ring in the near future! Played every Souls game so far and liked all of them.

They are planning to present the results in a conference and it would be the one that is in July.

Hopefully the others can tackle this problem. Would be great to be able to handle both hearing losses.

That is the case but it is better than nothing. The good news is that it works in humans. We'll just have to wait for the results and see how well it worked and the possibility of extending the effect with multiple doses.

Any thoughts how much this treatment would cost if it becomes available? After all it seems to be very simple procedure of injecting small molecules but it would still cost a lot. Wonder if this ever becomes available in local health centers rather than special clinics.

That is true. They said also that in song birds they not only regrow hair cells but they also connect all the way to the brain. That proves it.

@JohnAdams I found this thread today and it has been very exiciting to read about your journey to south korea and recovery. People like you can actually make difference by searching for treatments and sharing the experience and information. We have the ability to make impact for the future.

@JohnAdams Are Audion and Frequency Therapeutics the first to try signaling pathways or has there been already someone else?

I have literally falled asleep while voting in the last two nights :D Keep up the relentless voting!

As an European myself I don't believe there will be one universal treatment and that is good thing that every company is not trying the exactly same method. I don't care who provides the treatment as long as it is safe and effective but I agree as well that European system is somewhat faster and...

What levels of hearing loss the patients had who attended this FX-322 trial? I thought that they believe that with hearing loss only hear cells are lost but everything else is there such as the progenitor cells.