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I think most who consider tinnitus to be disconnected from hearing loss use an audiogram and think "I have no hearing loss, but I have tinnitus. Therefore tinnitus is not connected to hearing loss". However it's not as simple as that. Audiograms are really blunt tools and hearing loss comes in...

Calcium ion channels are also involved in the accrue phase. If I remember correctly release of calcium is one of the steps in the cascade of things leading to hair cell death after loud noise exposure.

Anti-inflammatory makes me believe it belongs to the same category as AM-101/Keyzilen, meaning it's geared towards treating tinnitus at the earliest stage (the so called acute phase).

If you listen to the Tinnitus Talk Podcast about Frequency Therapeutics with their representative Carl LeBel, he speaks about this. At Frequency they think that so called hidden hearing loss is actually hearing loss at the high frequencies that a normal hearing test doesn't test but that it...

Agreed. I don't use the dryers either. If there are no paper towels I just give my hands a quick shake after washing and then just let them air dry. It's not like your hands are going to stay wet for hours. They're dry within two minutes. But then again even if the dryers are loud you aren't...

We don't know. We can only speculate. But I believe I've read somewhere that someone from Frequency Therapeutics said that they had indications that this is the case. That nerves do grow out and attach to the new hair cells.

What about long term use? In the trials they only did the treatment for a number of weeks. But we still don't know what would happen if someone were to do the treatment continuously for, let's say 2 years!? If I recall correctly @kelpiemsp talked about a cumulative effect on his treatment in...

True but still important. To be honest there is nothing in the area of treatment that I could read about in his research. So talking about anything being marketed at all as of now is just dreaming. But nonetheless the research into the root cause of tinnitus is very important and we should not...

I've never advocated TRT. I have made my stance on TRT vocal several times on this forum. I find it to be a complete waste of time and money.

This is simply not true. Hearing usually deteriorates over time. Listening to headphones at higher volumes for hours over a longer period will have a profoundly negative effect on your hearing. This has nothing to do with what most people do or don't do. If most people jumped off of buildings it...

Listening to music using headphones can get you up over 100 dB, depending on headphones and HiFi equipment can definitely get you over 100 dB, which is more than enough to do serious damage.

Not JUST 2. At least 2. Multiple implies more than 1, which is AT LEAST 2. But there could be more.

Well, the US were leading in the field at the time so cutting the funding killed and/or slowed down progress. Which set the field back a number of years.

You can read it in a press release note on Frequancy Therapeutics home page. http://www.frequencytx.com/news-events/news-events-press-release-04-09-2019.php "In the Phase 1/2 study, FX-322 was safe and well tolerated following a single intratympanic injection with no serious adverse events. In...

Well, maybe. More than one person had some improvement in hearing. But we don't know if that is due to new cells, new cells connecting to existing nerve, new cells AND a new nerve growth or just a restoration of the ribbon synapse between existing cells and existing nerves. And we won't know...

For me it's been ups and downs. When I got it back in 2006 it took me about 2-3 years to habituate. After those first couple of years I rarely thought about tinnitus for years. Yes it was always present but it didn't bother me and I could just "send it" to the back of my mind and be happy. Then...

It's possible that regrown cells don't attach to a nerve and if they do regrown cells might perform worse than cells you're born with. Yes birds and zebra fish regrow hair cells but for them it's a normal mechanism. In mammals when hair cells die off there is scarring forming in those areas...

As I said don't confuse machine learning with AI. And also, as we can learn from tinnitus research, they always over sell the idea in articles.

I never said people don't suffer. Absence of suffering isn't the same thing as moving on. I suffer but I still try living my life.

I don't have the citations from studies or so but if you think about it logically you will come to the conclusion that most people do learn to move on. The figures are that around 10-15% of the general population experiences tinnitus of some kind. That is literally hundreds of millions of people...

Reason: George W. Bush! George W. Bush banned federal funding for stem cell research which set the field back many, many years.

Potentially, better. But all we can do now is speculate. We don't even know if the drug works at all as it's intended. And even if it does we still don't know if it will help people with tinnitus and/or hyperacusis. But restoring damaged hearing should potentially help with both tinnitus and...

Because nearly 100% of all people who have tinnitus have hearing loss. And even those who "don't", like me, probably do. It's just not measurable in a standard hearing test (try searching for "hidden hearing loss" on the forums or Google). Now you might say that not all people with hearing loss...

Frequency Therapeutics FX-322 University of Minnesota device

Probably yes. It's one thing saying you would in a theoretical scenario like this and another actually doing it when presented with the option in real life. But for me personally I'd probably risk it. I'm so tired and fed up with this condition. The only thing keeping me from eating a bullet...

Well, the chances are that most of those who are said to not have hearing loss indeed do have some hearing loss. The problem is that hearing usually isn't measured over 8000 Hz and so someone could have hearing loss in the higher frequencies. Also there is hidden hearing loss where single tones...

https://en.wikipedia.org/wiki/AlphaZero That might be the end goal perhaps?

No, not any game. Just three board games (Chess, Go and Shogi).

Sure. But will we do all that by 2030? It might sound far away but 10 years is not that awful long of time. And saying stuff like "if we solve natural language we basically have an AGI" is just not correct in the slightest. Also don't confuse machine learning with AI. Yes, we might be able to...

No, the first AGI will probably not be programmed by humans only. It would probably have to be an AI that we create that can improve its own code and iteratively get better over time. And we're just not there yet. We are just scratching the surface. And STILL all those you mention have been AIs...

There is no consensus in the matter among AI researchers. Some believe 2030 and some say never. I never said ALL of them said not by 2030. But then again in the 60's they also started to think about this matter and feared that computers would surpass humans in a matter of years. And what they...

I'm a sci-fi guy too. I have written in several posts here before that I believe that the ultimate solution will not be regenerative medicine but a very advanced cochlear implant that can be inserted into the inner ear and replace a damaged cochlea and not only perfectly mimic the human cochlea...

And Moore's law has been broken for the past half decade or so. The development of the 7 nm generation of processors has taken more than 2 years already hence causing the breakage of Moore's law. The problem is that we can't shrink transistors beyond a certain threshold and the closer we get...

That's funny since most AI scientists don't believe we will have an AGI for at least another 30-40 years, if ever! There actually are AI scientists who claim we won't ever be able to do it. I'm working as a software developer and I can tell you there is a huge difference between developing an...

I firmly believe that implants will be the ultimate cure. Once we've developed an implant to perfectly mimic the human inner ear that is. Just imagine being able to have perfect hearing your whole life without ever having to fear tinnitus or hearing loss ever again.

Stage 1 I think. But not started yet. He just got the money for it.

The funding for tinnitus is low as it is. We aren't getting even a fraction of what cancer research is for example. So to make it short, we have a limited amount of funding. And by spending chunks of it on TRT/CBT/Mindfulness or other coping strategies we are decreasing the funding towards a...

Actually the Trobalt redesigned is being developed by Prof. Tzounopoulos att University of Pittsburgh. He recently secured funding from the US military to go ahead with a trial of his potassium ion channel drug aimed for tinnitus.

The point is the you need it delivered at the precise location in your cochlea. Even if you manage to keep most of it in your middle ear you actually want it in your inner ear and your cochlea specifically, so much of the medication will be lost no matter how you do it. Delivering drugs using...

They may be for now. But you might not need as much of a medicine if it's delivered at the precise location where it's needed. When you inject a drug a lot of it will dissipate and not end up where it's needed.

I'd take 40 injections over 40 years of tinnitus any time!

Great to get an update. I do have a follow up question though which I'm hoping you might have an answer to or at least a hum, but I get it if you don't. You said you had multiple tones, so do I. How is the treatment working for that? I imagine you might have asked about it. Can they treat both...

I'm not sure that a meeting once a month between all tinnitus researchers is either useful or practical. First it would be extremely difficult to perform. There are several annual conferences that are organised already and they each take a lot of time, at least a whole day and sometimes several...

There is no way of measuring long term side effects without it taking a very long time. I think we will just have to be happy when any treatment comes around. Long term side effects might show up in 30 years. I for one am NOT going to sit around and wait for those assessments when a treatment...

There is a lot of research going towards pain medication and antibiotics. We've had the Aspirin and Penicilin for almost 100 years. FX-322 hasn't even been properly tested yet, don't think of it as a done deal just yet. And even if it already were out there is always room for improvement. It's...

Yeah, this is absolutely right. The patenting process is a joke. There is a guy in Australia that managed to write a patent application and get it approved that would make him own the patent for the wheel. That's right! The wheel! The thing invented thousands of years ago. Of course he didn't...

We already have people that have had complete resolution of their tinnitus from various reasons ranging all from cochlear implants to having a stroke. One can also alleviate tinnitus by injecting lidocaine intravenously, that would give you silence for about 30 min. So clearly it's possible...

I was tinnitus free for the first 22 years of my life. Why hasn't that been permanently entrenched in my brain?

If damage to the inner ear drives brain plasticity to produce tinnitus. Wouldn't repairing the damage drive the same brain plasticity mechanism to revert back to normal? As far as I understand it our brain fills in for gaps in neural input. The same thing happens in our vision and the so called...

Oh and by the way. Genetically modified E-coli is pretty standard for producing certain organic compounds. Genetically modified yeast is another. They are used to produce a variety of drugs such as antibiotics, vaccines and human hormones. Penicillin is also yeast poop. Alcoholic beverages and a...

Both refer to the same study and it is deeply flawed. Just for one, all rats died from natural causes. Meaning they were all old when they died. Cancer is a disease tightly linked with high age. In autopsies of humans around half of men aged 75 or more were found to have undiagnosed prostate...

No, it didn't. It's been a lot of trash talking and rumors about aspartame through the years, hence the rigorous testing of it. But it's not dangerous in any way. In fact, in animal testing it was proven to be safe to consume an equivalent of many multitudes higher than what any human could ever...

Well, Aspartame is a dipeptide (it consists of two amino acids), witch technically makes it a protein. It was actually approved by the FDA in 1981 but was first created in 1965. So it took nearly 20 years before it was approved to be used in food as a sweetener. Aspartame is actually one of the...

What do you mean?

Because it's not a drug per se. It's a naturally occurring flavone that can be found in leaves of certain trees. And extracts from plants are usually not considered drugs unless they are to be banned for some reason such as cocaine and marijuana, or they want to get them approved for treatment...

The problem is that there is a protocol that needs to be followed. First you need to show that your drug is safe on healthy subjects before you can test it on sick people. In the case of tinnitus it might be possible to skip this one but what about issues where the sick people are in a really...

"To follow both these aspects we select donor umbilical cord tissue-derived mesenchymal stem cells (MSCs)." Source: https://stemcells21.com/about-stem-cells/mesenchymal-stem-cells/

There is a lot of information in the treatments section in the threads about stem cells. There is also some research papers on the subject. Very recently a study using stem cell treatments on deaf children was published, I think it can be found here on the forums too. There is also a lot of...

Well, pretty much everything you read everyday is "allegedly". All the research papers shared on this forum can also be seen as "allegedly" since they're all written by the people who allegedly conducted the experiments. In the case of research papers there is actually more to be gained by...

There are members on this forum that have hade successful stem cell treatments. The first one did it 5 years ago.