I believe McLean stated that they had better results in vitro growing vestibular hair cells but I don't think there's a way to get the substance into that part of the ear. I could be wrong. Dana White said PRP cured his Meniere's disease but we don't know if he had damage to his vestibular hair cells or a nerve(s) and exactly what the PRP acted on.
Well I spoke to the investigators and they are testing for improvements. They said if they see improvement, some of the participants could be asked to come back for another dose. They are 100% testing for efficiency. Stop saying they aren't. If you're new here, be new here, and don't pretend like you know. Some of us were trying to get into the study and spoke to the doctors and investigators.
Nobody knows for sure if it will work for hyperacusis. Because we truly don`t know what the root cause of hyperacusis is at this time. But there are some theories about what the cause could be. One theory is as follows, taken from:
The "experts" say we get hyperacusis because our brains are amplifying sound to try to make up for the frequency we can no longer hear. Correct the hearing; correct the sound amplification. I'm just speculating but I'm sure other smarter people have done the same.
It is a bit odd that the 42 million in funding came in right before the conference. I bet the investors already had all the information they needed and the conference was just a formality. This is good news though since they would have had the results and they must have been positive for them to fork over 42 million.
Yes this is true. I am guessing that one dose is not going to be enough and they will have to start testing the effects of multiple doses and the dosing schedule.
With new developments in the works we might not need any injections. A magnet and nano particles can move drugs through membranes now apparently.
They may be for now. But you might not need as much of a medicine if it's delivered at the precise location where it's needed.
In the middle ear, as long as you lie on your back with your head tilted and don't swallow, it will stay in there fine and not dissipate, especially if there is enough viscosity. I've had 72 intratympanic injections over the last 2 weeks so I have some experience here.
Drug dosage always takes into account the absorption rate based on its ingestion method. For example IV has a high absorption rate, but less so for oral, so the dosage is adjusted so your body gets the right amount of meds given the losses "in transit".
Yes, it will be great. In the meantime, we have to use technology from the present.
Love this drug, the thread, and your contributions. I live in Laos, but my hometown is Boston. I wrote Frequency Therapeutics, asking to get involved in the next trial. They returned my email and basically brushed me off and said it's out of their hands, etc.
I wish I knew. The investigators for the last trial might not be the same ones.
Curious, when did you send that message? And to which email address?
I did not request results, just asked to be in the next trial.
Best case scenario, Frequency Therapeutics has got everything figured out and no longer is in need of this man's skills and abilities, and he has decided to go to Decibel Therapeutics to help them develop their product.
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