Frequency Therapeutics — Hearing Loss Regeneration

[Silvio Sabo]

False. Get your facts straight first. AM-101 was patented and it failed in the trials. Many drugs are patented and fail in clinical trials.

Yeah, this is absolutely right. The patenting process is a joke. There is a guy in Australia that managed to write a patent application and get it approved that would make him own the patent for the wheel. That's right! The wheel! The thing invented thousands of years ago. Of course he didn't write "wheel "in his application but non the less he got a paper from the patent office that he was the rightful patent owner of "a circular transportation facilitation device". Funny story!

Anyways, you are right, patents are applied before testing. As soon as you make a new chemical compound that can potentially be used for anything, you apply for a patent.

 

[85dB T]

. I posted an article a while ago about a guy who got a cochlear implant after decades of losing hearing, and somehow the "connection" still worked from the cochlea to the brain, so the electrical signal from the CI electrode did make its way to the hearing nerve somehow.

Rush Limbaugh detailed his experience in an interview made public.

Apparently his implant has software. After trial and error he found a combination of old version software in one ear and new software in the other produced an acceptable result. All one or the other wasn't producing useful hearing.

(He said if he hadn't stumbled upon this his career would have been lost. It was his idea to combine the two, not the doctors. They resisted him trying to mix the two.)

I may have bookmarked this interview transcript. I'll post it if I find it (I could be wrong regarding exactly what he said).

 

[Street Novelist]

Yeah, I don't get that. If putting a needle through your eardrum and injecting the drug causes hearing loss, what's the point?

 

[Enclave]

Yes it is me.

Hearing loss was a possible risk from injection and altering the mechanical parts of your inner ear might cause hearing loss as well. Also there is a bit in there about dosage.

They are making an educated guess right now on what will be enough. The hair cells could start to grow, and stop and leave you without any more sets of progenitor cells if they get it right later. Shit... Now that I'm talking about it I missed my chance. F@&$.

Can you elaborate further on the bit about dosage?

Can you elaborate further on why they believe that altering the mechanical parts of your inner ear might have negative impact?

Since you bowed out, did you have to sign a NDA?

What questions did you ask them during their screening process?

 

[PlsHelpMe]

Can this also cure NIHL?

 

[Pero1234]

Or I had a good chance of getting the half dose or placebo and that is why I ultimately decided not to. That would suck to spend 4 grand traveling back and forth and only get a hole in your ear.

Exactly...

Better to get in at a later phase... when the chances for success are higher!

Or just get it when it's released... when chances for success are highest and risks are lower!

 

[Johan_L]

Or I had a good chance of getting the half dose or placebo and that is why I ultimately decided not to. That would suck to spend 4 grand traveling back and forth and only get a hole in your ear.

Don't they offer the real thing (for free) after the trial if you got placebo?

 

[d'Wooluf]

Don't they offer the real thing (for free) after the trial if you got placebo?

Even if they did, the four grand saved in travelling expenses would hopefully cover the cost anyway. I said "hopefully".

 

[PDodge]

Can this also cure NIHL?

This is for ALL hearing loss.

 

[Ed209]

This is for ALL hearing loss.

It is for mild to moderate, noise-induced, hearing loss; essentially the hearing aid market rather than the cochlear implant market. It is not targeted at people with conductive or congenital hearing loss, for example.

 

[Jason37]

Can you elaborate further on the bit about dosage?

Can you elaborate further on why they believe that altering the mechanical parts of your inner ear might have negative impact?

Since you bowed out, did you have to sign a NDA?

What questions did you ask them during their screening process?

I think it has to do with the dosage...maybe they will need more to make it work or maybe it could make the signal go haywire. I don't know exactly but it just said that there was a risk of the unknown effects.Plus a hole in the eardrum which should heal.

 

[Jason37]

Don't they offer the real thing (for free) after the trial if you got placebo?

I think so but who knows... at least that is what they told me.

 

[PDodge]

It is for mild to moderate, noise-induced, hearing loss; essentially the hearing aid market rather than the cochlear implant market. It is not targeted at people with conductive or congenital hearing loss, for example.

Thanks for correcting me! I knew I was wrong when I posted it.

This is for ALL hearing loss.

This is wrong.

 

[GregCA]

It is for mild to moderate, noise-induced, hearing loss; essentially the hearing aid market rather than the cochlear implant market. It is not targeted at people with conductive or congenital hearing loss, for example.

This may be a bit pedantic, but I think it's not limited to noise-induced hearing loss: there could be other conditions that affect hair cells that could benefit from this treatment.
I'm thinking of people who lose hearing because of ototoxic meds, or through the nasty byproduct of otosclerosis (O is mainly a conductive loss, but in some cases - ask me how I know - the process also kills hair cells in the cochlea resulting in sensorineural losses).

 

[Ed209]

This may be a bit pedantic, but I think it's not limited to noise-induced hearing loss: there could be other conditions that affect hair cells that could benefit from this treatment.
I'm thinking of people who lose hearing because of ototoxic meds, or through the nasty byproduct of otosclerosis (O is mainly a conductive loss, but in some cases - ask me how I know - the process also kills hair cells in the cochlea resulting in sensorineural losses).

Yea, it should logically include ototoxicity unless I'm missing something. Frequency quite frequently (see what I did there ) mention that FX-322 targets mild to moderate hearing loss caused by noise pollution, but this should include all sensorineural hearing loss. I was mainly thinking along the lines of conductive loss and congenital hearing loss as being outside of their criteria, as ALL hearing loss seemed too much of a sweeping statement.

 

[Striveon]

It is for mild to moderate, noise-induced, hearing loss; essentially the hearing aid market rather than the cochlear implant market. It is not targeted at people with conductive or congenital hearing loss, for example.

Congenital hearing loss? Can you define that...? Do you mean if it was present at birth you can't have FX-22? Or hearing loss due to a disease...?

 

[Ed209]

Congenital hearing loss? Can you define that...? Do you mean if it was present at birth you can't have FX-22? Or hearing loss due to a disease...?

Yea. Congenital is hearing loss from birth. I'm just going by what David Lucchino has said, but maybe it could work for that too? It's also possible it could work for more severe losses, but it seems they are going after the moderate losses first.

As far as conductive hearing loss goes, it would be no good.

 

[Striveon]

Yeah genetic stable sensorineural hearing loss.

Yea. Congenital is hearing loss from birth. I'm just going by what David Lucchino has said, but maybe it could work for that too? It's also possible it could work for more severe losses, but it seems they are going after the moderate losses first.

As far as conductive hearing loss goes, it would be no good.

I have stable moderate hearing loss and was diagnosed at age 5, most likely was born with hearing loss... so would that not work? I'm confused since it's still hearing loss... I dont see the difference...

 

[Remjii79]

I have stable moderate hearing loss and was diagnosed at age 5, most likely was born with hearing loss... so would that not work? I'm confused since it's still hearing loss... I dont see the difference...

Ditto man! In my case, they think it was from birth but I also had a few ear infections as an infant but I don't think that they said that was the cause (although they didn't necessarily rule it out)... I'm just labeled as "congenital hearing loss". I've had MRI's, structurally, everything looks good otherwise. I believe I am in the moderate to severe range. I do ok without aids but once I put them in it's clear how much I'm actually missing, especially in high frequencies. Didn't know birds were so damn loud!

**Edit for additional info

 

[Ed209]

I have stable moderate hearing loss and was diagnosed at age 5, most likely was born with hearing loss... so would that not work? I'm confused since it's still hearing loss... I dont see the difference...

What you're born with is what you get, so if there's a genetic component, I don't think it will work.

It's my assumption - and please shoot me down if I'm wrong, or you know otherwise - is that you can't regenerate something that isn't there to begin with. I think the clue is in the word 'regeneration'.

 

[Chestnut94]

I have stable moderate hearing loss and was diagnosed at age 5, most likely was born with hearing loss... so would that not work? I'm confused since it's still hearing loss... I dont see the difference...

I don't know this for sure, but I would guess that if you were born with this hearing loss, it will not work since your hearing loss is genetic, so it would be "normal" for your body.

 

[rid0871]

I would have done anything to be in that trial. I can't do this much longer. Really I can't. I begged them sooo very much.

 

[Striveon]

Ditto man! In my case, they think it was from birth but I also had a few ear infections as an infant but I don't think that they said that was the cause (although they didn't necessarily rule it out)... I'm just labeled as "congenital hearing loss". I've had MRI's, structurally, everything looks good otherwise. I believe I am in the moderate to severe range. I do ok without aids but once I put them in it's clear how much I'm actually missing, especially in high frequencies. Didn't know birds were so damn loud!

**Edit for additional info

Exactly... structurally everything is okay... and the doctor said my problem is that I am missing outer hair cells. I can also hear conversations well, I can hear the difference with hearing aids on. I don't see why this wouldn't work?

 

[Striveon]

@JohnAdams what do you think? Would it not work for congenital hearing loss?

 

[Remjii79]

Exactly... structurally everything is okay... and the doctor said my problem is that I am missing outer hair cells. I can also hear conversations well, I can hear the difference with hearing aids on. I don't see why this wouldn't work?

I'm hopeful. People here might be right that it might not help for congenital but they aren't docs and they don't know for sure. When the time comes you and your doc can discuss whether or not it would be useful. I would surmise that it could still work under certain scenarios... and not work under others. So... imo we will have to wait and see.

 

[Striveon]

I'm hopeful. People here might be right that it might not help for congenital but they aren't docs and they don't know for sure. When the time comes you and your doc can discuss whether or not it would be useful. I would surmise that it could still work under certain scenarios... and not work under others. So... imo we will have to wait and see.

That's true, you're right. Just wait and see I guess.

 

[Zeneth]

Yeah, I don't get that. If putting a needle through your eardrum and injecting the drug causes hearing loss, what's the point?

I doubt they'd even be trying if that were the case.

 

[GregCA]

If putting a needle through your eardrum and injecting the drug causes hearing loss

It doesn't (generally speaking).

 

[grate_biff]

Anybody else feel like they are burning alive, 10 feet from the water that may or may not be a mirage?

 

[JohnAdams]

@JohnAdams what do you think? Would it not work for congenital hearing loss?

I'm honored you seek my opinion.

To be honest. I don't know. I don't know enough about congenital hearing loss to form an opinion.

My opinion is thus: if you have NIHL or ototoxicity related hearing loss and tinnitus as a result, then it seems like it will help with that, especially high frequency hearing loss.

I also believe this will alleviate many cases of tinnitus. But what do I know?